Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q9UQ84)
Protein (NX_Q9UQ84)
Protein
Gene SymbolEXO1 to neXtProt (NX_Q9UQ84)
DescriptionExonuclease 1
Chromosome1
Location1q43 (242011269 ~ 242058450) to Ensembl
Sequene Features : Isoforms 2, Variants 146, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA phosphodiester bond hydrolysis, endonucleolytic
.nucleic acid phosphodiester bond hydrolysis
.meiotic cell cycle
  + 6 more...
.double-stranded DNA 5'-3' exodeoxyribonuclease activity
.flap endonuclease activity
.metal ion binding
  + 7 more...
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 146 15
2014-09-19protein level
2 123 15
2014-05-27protein level
2 122 15
2014-02-25protein level
2 122 15
2013-12-09protein level
2 104 15
2013-11-01protein level
2 102 14
2013-09-12protein level
2 102 14
2013-08-17protein level
2 102 14
2013-07-15protein level
2 71 14
2013-06-11protein level
2 71 14
2013-02-12protein level
2 47 30
2012-12-20protein level
2 47 30
2012-10-30protein level
2 54 30
2012-10-07protein level
2 54 15
2012-08-24protein level
2 54 15
2012-07-28protein level
2 54 15
2012-06-08protein level
2 62 15
2012-05-07protein level
2 57 15
2012-04-10protein level
2 57 15
2012-01-13protein level
2 45 15
2011-12-20protein level
2 45 15
2011-11-11protein level
2 45 15
2011-08-23protein level
2 45 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UQ84-1
1 39 0 94044.325
NX_Q9UQ84-4
0 39 0 89174.8485
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-944694,EBI-355888 MSH2  
  .positive regulation of helicase activity
.negative regulation of DNA recombination
.isotype switching
  + 23 more...
.protein homodimerization activity
.guanine/thymine mispair binding
.protein kinase binding
  + 10 more...
.MutSbeta complex
.MutSalpha complex
.membrane
  + 2 more...
2 EBI-944667,EBI-745715 RBBP8  
  .meiotic cell cycle
.cell division
.G2 DNA damage checkpoint
  + 10 more...
.damaged DNA binding
.RNA polymerase II transcription corepressor activity
.RNA polymerase II repressing transcription factor binding
.single-stranded DNA endodeoxyribonuclease activity
.transcriptional repressor complex
.nucleolus
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites50
bone125
bone marrow41
brain6
cervix82
connective tissue20
ear124
embryonic tissue32
eye14
heart22
intestine4
kidney14
liver14
lung23
lymph node22
mammary gland13
mouth30
placenta10
salivary gland98
skin56
stomach20
testis45
thymus112
uterus21
Health State
TissuesTPM*
normal12
adrenal tumor158
breast (mammary gland) tumor21
cervical tumor115
chondrosarcoma108
gastrointestinal tumor33
germ cell tumor56
glioma18
head and neck tumor14
kidney tumor14
leukemia10
liver tumor20
lung tumor68
lymphoma27
primitive neuroectodermal tumor of the CNS47
retinoblastoma64
skin tumor79
uterine tumor55
Developmental Stage
TissuesTPM*
adult22
embryoid body14
blastocyst48
neonate64
fetus32
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix3.5
bone marrow11.2
colon3
duodenum2.5
esophagus2.9
lymph node5.6
placenta3.5
skin1.6
small intestine2.5
spleen1.2
stomach1.6
testis5.7
urinary bladder2.2
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*606063, gene) Exonuclease 1, s. cerevisiae, homolog of; EXO1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center