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> Protein (NX_Q9UQ90)
Protein (NX_Q9UQ90)
Protein
Gene SymbolSPG7 to neXtProt (NX_Q9UQ90)
DescriptionParaplegin
Chromosome16
Location16q24.3 (89557325 ~ 89624176) to Ensembl
Sequene Features : Isoforms 2, Variants 105, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.anterograde axon cargo transport
.nervous system development
.mitochondrion organization
.proteolysis
.unfolded protein binding
.zinc ion binding
.peptidase activity
  + 2 more...
.mitochondrial membrane
.integral component of membrane
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 105 1
2014-09-19protein level
2 87 1
2014-05-27protein level
2 87 1
2014-02-25protein level
2 86 1
2013-12-09protein level
2 62 1
2013-11-01protein level
2 60 1
2013-09-12protein level
2 60 1
2013-08-17protein level
2 60 1
2013-07-15protein level
2 52 1
2013-06-11protein level
2 52 1
2013-02-12protein level
2 34 1
2012-12-20protein level
2 37 1
2012-10-30protein level
2 43 1
2012-10-07protein level
2 43 1
2012-08-24protein level
2 42 1
2012-07-28protein level
2 42 1
2012-06-08protein level
2 45 1
2012-05-07protein level
2 40 1
2012-04-10protein level
2 40 1
2012-01-13protein level
2 36 1
2011-12-20protein level
2 36 1
2011-11-11protein level
2 36 1
2011-08-23protein level
2 36 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UQ90-1
17 18 0 88178.6339
NX_Q9UQ90-2
3 18 0 53905.0929
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-717201,EBI-1050964 PSTPIP1  
  .innate immune response
.nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
.signal transduction
  + 3 more...
.N/A .perinuclear region of cytoplasm
.cleavage furrow
.lamellipodium
  + 5 more...
2 EBI-717201,EBI-748961 CCNDBP1  
  .regulation of cell cycle
.cell cycle
.N/A .cytoplasm
.nucleoplasm
.nucleus
3 EBI-717201,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
4 EBI-717201,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
5 EBI-717201,EBI-355546 PSME3  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.MDM2/MDM4 family protein binding
.endopeptidase activator activity
.identical protein binding
.p53 binding
.membrane
.proteasome activator complex
.cytosol
  + 4 more...
6 EBI-717201,EBI-304185 HNRNPK  
  .regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
.positive regulation of receptor-mediated endocytosis
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
  + 2 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cell projection
  + 7 more...
7 EBI-717201,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
8 EBI-717201,EBI-742808 KHDRBS2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(U) RNA binding
.poly(A) binding
.nucleus
9 EBI-717201,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
10 EBI-717201,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
11 EBI-717201,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
12 EBI-717201,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
13 EBI-717201,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
14 EBI-717201,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites150
bladder33
blood40
bone97
bone marrow20
brain64
connective tissue73
ear124
embryonic tissue112
eye71
heart134
intestine90
kidney80
larynx170
liver92
lung116
lymph node55
mammary gland125
mouth30
muscle75
nerve193
ovary157
pancreas51
pharynx73
pituitary gland121
placenta52
prostate79
salivary gland49
skin52
spleen74
stomach125
testis126
thymus37
thyroid85
tonsil58
trachea19
uterus94
Health State
TissuesTPM*
normal65
bladder carcinoma56
breast (mammary gland) tumor139
chondrosarcoma205
colorectal tumor124
gastrointestinal tumor118
germ cell tumor79
glioma102
head and neck tumor59
kidney tumor145
leukemia95
liver tumor93
lung tumor87
lymphoma83
non-neoplasia51
ovarian tumor39
pancreatic tumor95
primitive neuroectodermal tumor of the CNS47
prostate cancer96
retinoblastoma86
skin tumor55
soft tissue/muscle tissue tumor63
uterine tumor110
Developmental Stage
TissuesTPM*
adult93
embryoid body128
blastocyst162
fetus61
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24.8
adrenal gland36.4
appendix39.1
bone marrow37.5
cerebral cortex31.1
colon30.7
duodenum38
esophagus23.4
gallbladder32
heart muscle39.1
kidney32.9
liver21.1
lung41.8
lymph node41.7
ovary35.8
pancreas17
placenta20.7
prostate28.9
salivary gland26.7
skin74.9
small intestine38.2
spleen49.6
stomach34.6
testis43.1
thyroid gland48.7
urinary bladder26.5
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*602783, gene) Spg7 gene; SPG7OMIM
2(#607259, phenotype) Spastic paraplegia 7, autosomal recessive; SPG7OMIM


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