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> Protein (NX_Q9UQB8)
Protein (NX_Q9UQB8)
Protein
Gene SymbolBAIAP2 to neXtProt (NX_Q9UQB8)
DescriptionBrain-specific angiogenesis inhibitor 1-associated protein 2
Chromosome17
Location17q25.3 (79008948 ~ 79091232) to Ensembl
Sequene Features : Isoforms 6, Variants 57, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of actin cytoskeleton reorganization
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.proline-rich region binding
.identical protein binding
.cytoskeletal adaptor activity
.protein C-terminus binding
.extracellular exosome
.neuron projection
.filopodium
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 57 10
2014-09-19protein level
6 41 10
2014-05-27protein level
6 41 10
2014-02-25protein level
6 41 10
2013-12-09protein level
6 31 10
2013-11-01protein level
6 26 10
2013-09-12protein level
6 26 12
2013-08-17protein level
6 26 12
2013-07-15protein level
6 17 12
2013-06-11protein level
6 17 12
2013-02-12protein level
6 4 90
2012-12-20protein level
6 4 90
2012-10-30protein level
6 7 90
2012-10-07protein level
6 7 15
2012-08-24protein level
6 7 15
2012-07-28protein level
6 7 15
2012-06-08protein level
6 11 15
2012-05-07protein level
6 11 15
2012-04-10protein level
6 11 15
2012-01-13protein level
6 11 15
2011-12-20protein level
6 12 15
2011-11-11protein level
6 12 14
2011-08-23protein level
6 12 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UQB8-1
2 29 0 60829.4425
NX_Q9UQB8-2
0 29 0 58976.6496
NX_Q9UQB8-3
0 28 0 56590.3809
NX_Q9UQB8-4
0 29 0 57322.7331
NX_Q9UQB8-5
1 28 0 57408.7598
NX_Q9UQB8-6
1 28 0 57393.77
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6174091,EBI-748201 VASP  
  .protein homotetramerization
.T cell receptor signaling pathway
.cell junction assembly
  + 4 more...
.profilin binding .extracellular exosome
.filopodium membrane
.lamellipodium membrane
  + 6 more...
2 EBI-6174091,EBI-81752 CDC42  
  .positive regulation of substrate adhesion-dependent cell spreading
.positive regulation of intracellular protein transport
.epithelial cell-cell adhesion
  + 61 more...
.identical protein binding
.apolipoprotein A-I receptor binding
.thioesterase binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.spindle midzone
  + 17 more...
3 EBI-525456,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
4 EBI-525456,EBI-375576 EPS8  
  .actin polymerization-dependent cell motility
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.Rac GTPase binding
.SH3/SH2 adaptor activity
.actin binding
.extracellular exosome
.ruffle membrane
.stereocilium
  + 6 more...
5 EBI-525456,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
6 EBI-525456,EBI-2556221 KANK1  
  .negative regulation of lamellipodium morphogenesis
.regulation of establishment of cell polarity
.negative regulation of ruffle assembly
  + 11 more...
.beta-catenin binding .ruffle membrane
.cytoplasm
.nucleus
7 EBI-525456,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
8 EBI-9091996,EBI-524753 ZDHHC17  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.lipoprotein transport
.protein palmitoylation
  + 2 more...
.identical protein binding
.protein-cysteine S-palmitoyltransferase activity
.palmitoyltransferase activity
  + 3 more...
.intracellular membrane-bounded organelle
.Golgi-associated vesicle membrane
.integral component of membrane
  + 3 more...
9 EBI-525456,EBI-740924 PRR13  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
10 EBI-525456,EBI-745080 NCKIPSD  
  .innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
.small GTPase mediated signal transduction
  + 3 more...
.cytoskeletal protein binding .intermediate filament
.cytosol
.nucleus
11 EBI-525456,EBI-741214 C19orf25  
  .N/A .N/A .N/A
12 EBI-6174091,EBI-4290615 WASF2  
  .lamellipodium morphogenesis
.negative regulation of stress fiber assembly
.vascular endothelial growth factor receptor signaling pathway
  + 13 more...
.protein complex binding
.actin binding
.extracellular exosome
.SCAR complex
.lamellipodium
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder33
blood24
bone139
bone marrow41
brain204
cervix185
connective tissue46
embryonic tissue23
esophagus49
eye191
heart11
intestine60
kidney33
larynx42
liver112
lung83
mammary gland99
mouth151
muscle9
nerve128
ovary19
pancreas89
parathyroid97
pituitary gland60
placenta148
prostate110
skin94
spleen37
stomach52
testis105
thymus50
trachea115
uterus47
vascular58
Health State
TissuesTPM*
normal106
bladder carcinoma56
breast (mammary gland) tumor85
chondrosarcoma84
colorectal tumor26
esophageal tumor57
gastrointestinal tumor59
germ cell tumor64
glioma139
head and neck tumor67
kidney tumor29
leukemia31
liver tumor177
lung tumor87
lymphoma27
non-neoplasia93
ovarian tumor13
pancreatic tumor152
primitive neuroectodermal tumor of the CNS283
prostate cancer28
retinoblastoma559
skin tumor111
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult81
blastocyst32
neonate32
fetus64
infant297
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.3
adrenal gland16
appendix9
bone marrow2.2
cerebral cortex60.8
colon11.8
duodenum6.2
esophagus98.7
gallbladder31.7
heart muscle13.3
kidney31.9
liver34.2
lung43.9
lymph node5.6
ovary10.1
pancreas6.1
placenta35
prostate47.1
salivary gland22.6
skin97.1
small intestine5.9
spleen10.9
stomach37.4
testis21.4
thyroid gland23.1
urinary bladder24.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeLow
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605475, gene) Bai1-associated protein 2; BAIAP2OMIM


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