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> Protein (NX_Q9UQC2)
Protein (NX_Q9UQC2)
Protein
Gene SymbolGAB2 to neXtProt (NX_Q9UQC2)
DescriptionGRB2-associated-binding protein 2
Chromosome11
Location11q14.1 (77926343 ~ 78129394) to Ensembl
Sequene Features : Isoforms 2, Variants 87, PTMs 26 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.phosphatidylinositol-mediated signaling
.innate immune response
.positive regulation of mast cell degranulation
  + 6 more...
.phosphatidylinositol-3,4-bisphosphate binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.transmembrane receptor protein tyrosine kinase adaptor activity
.plasma membrane
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 87 26
2014-09-19protein level
2 74 26
2014-05-27protein level
2 74 26
2014-02-25protein level
2 74 26
2013-12-09protein level
2 58 26
2013-11-01protein level
2 58 26
2013-09-12protein level
2 58 26
2013-08-17protein level
2 58 26
2013-07-15protein level
2 38 26
2013-06-11protein level
2 38 26
2013-02-12protein level
2 31 54
2012-12-20protein level
2 33 54
2012-10-30protein level
2 39 54
2012-10-07protein level
2 39 27
2012-08-24protein level
2 29 27
2012-07-28protein level
2 29 27
2012-06-08protein level
2 31 27
2012-05-07protein level
2 31 27
2012-04-10protein level
2 31 27
2012-01-13protein level
2 24 27
2011-12-20protein level
2 24 27
2011-11-11protein level
2 24 27
2011-08-23protein level
2 24 27
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UQC2-1
1 31 0 74411.1557
NX_Q9UQC2-2
0 31 0 69924.732
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-975200,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
2 EBI-975200,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
3 EBI-975200,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
bone13
brain40
connective tissue13
embryonic tissue23
eye23
intestine21
kidney14
larynx42
lung20
lymph node11
mammary gland33
muscle56
ovary39
pancreas4
parathyroid48
placenta91
prostate5
salivary gland49
skin94
spleen37
testis13
thyroid21
umbilical cord145
uterus25
Health State
TissuesTPM*
normal21
breast (mammary gland) tumor53
chondrosarcoma24
colorectal tumor26
germ cell tumor56
glioma27
head and neck tumor14
kidney tumor29
leukemia10
lung tumor19
non-neoplasia41
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS149
skin tumor127
soft tissue/muscle tissue tumor39
uterine tumor55
Developmental Stage
TissuesTPM*
adult31
embryoid body57
neonate64
fetus19
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15
adrenal gland7.6
appendix11.9
bone marrow24.3
cerebral cortex19.9
colon9.8
duodenum12.3
esophagus7.5
gallbladder9.3
heart muscle11.9
kidney4.8
liver2.3
lung14.8
lymph node6.6
ovary19
pancreas2.8
placenta16.2
prostate5.1
salivary gland2.3
skin5.8
small intestine8.9
spleen12.8
stomach7.1
testis6.3
thyroid gland7.6
urinary bladder8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606203, gene) Grb2-associated binding protein 2; GAB2OMIM


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