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> Protein (NX_Q9UQF2)
Protein (NX_Q9UQF2)
Protein
Gene SymbolMAPK8IP1 to neXtProt (NX_Q9UQF2)
DescriptionC-Jun-amino-terminal kinase-interacting protein 1
Chromosome11
Location11p11.2 (45907202 ~ 45928016) to Ensembl
Sequene Features : Isoforms 1, Variants 65, PTMs 28 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of intrinsic apoptotic signaling pathway
.regulation of JNK cascade
.negative regulation of JUN kinase activity
  + 3 more...
.kinesin binding
.MAP-kinase scaffold activity
.protein kinase inhibitor activity
.perinuclear region of cytoplasm
.synapse
.dentate gyrus mossy fiber
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 65 28
2014-09-19protein level
1 49 28
2014-05-27protein level
1 49 29
2014-02-25protein level
1 49 29
2013-12-09protein level
1 40 29
2013-11-01protein level
1 39 29
2013-09-12protein level
1 39 29
2013-08-17protein level
1 39 29
2013-07-15protein level
1 23 29
2013-06-11protein level
1 23 29
2013-02-12protein level
1 11 28
2012-12-20protein level
1 11 28
2012-10-30protein level
1 14 3
2012-10-07protein level
1 14 3
2012-08-24protein level
1 13 3
2012-07-28protein level
1 13 3
2012-06-08protein level
1 17 3
2012-05-07protein level
1 14 3
2012-04-10protein level
1 14 3
2012-01-13protein level
1 12 3
2011-12-20protein level
1 12 3
2011-11-11protein level
1 12 3
2011-08-23protein level
1 12 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UQF2-1
35 0 0 77475.9243
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-78404,EBI-492605 MAP2K7  
  .cellular response to sorbitol
.stress-activated MAPK cascade
.innate immune response
  + 22 more...
.protein phosphatase binding
.protein kinase binding
.enzyme binding
  + 6 more...
.cytosol
.cytoplasm
.nucleus
.intracellular
2 EBI-78404,EBI-358684 MAP3K7  
  .negative regulation of apoptotic signaling pathway
.regulation of reactive oxygen species metabolic process
.negative regulation of ripoptosome assembly involved in necroptotic process
  + 37 more...
.scaffold protein binding
.ATP binding
.MAP kinase kinase kinase activity
  + 4 more...
.endosome membrane
.plasma membrane
.cytosol
  + 4 more...
3 EBI-78404,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
4 EBI-78404,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
5 EBI-78404,EBI-286483 MAPK8  
  .positive regulation of determination of dorsal identity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.programmed necrotic cell death
  + 45 more...
.histone deacetylase binding
.histone deacetylase regulator activity
.enzyme binding
  + 3 more...
.cytosol
.mitochondrion
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
brain93
embryonic tissue9
eye86
heart22
kidney37
liver4
lung14
mouth15
muscle28
nerve193
ovary29
pancreas65
parathyroid48
pituitary gland544
placenta3
prostate5
skin4
stomach10
testis16
uterus4
vascular19
Health State
TissuesTPM*
normal42
adrenal tumor79
gastrointestinal tumor8
germ cell tumor15
glioma83
head and neck tumor14
kidney tumor72
liver tumor10
lung tumor9
non-neoplasia31
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer9
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor23
uterine tumor11
Developmental Stage
TissuesTPM*
adult35
fetus23
infant212
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.4
adrenal gland11.2
appendix1.6
cerebral cortex53.7
colon1.6
duodenum1.2
esophagus1.2
gallbladder2.3
heart muscle1.7
kidney6.1
liver1.3
lung2.4
ovary3.5
pancreas12.7
placenta1.1
prostate4.7
salivary gland4.1
small intestine1.6
spleen1.3
stomach3.1
testis14
thyroid gland3.4
urinary bladder1.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#125853, phenotype) Diabetes mellitus, noninsulin-dependent; NIDDMOMIM
2(*604641, gene) Mitogen-activated protein kinase 8-interacting protein 1; MAPK8IP1OMIM


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