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> Protein (NX_Q9UQQ2)
Protein (NX_Q9UQQ2)
Protein
Gene SymbolSH2B3 to neXtProt (NX_Q9UQQ2)
DescriptionSH2B adapter protein 3
Chromosome12
Location12q24.12 (111843752 ~ 111889427) to Ensembl
Sequene Features : Isoforms 1, Variants 68, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.intracellular signal transduction
.embryonic hemopoiesis
.cell differentiation
.blood coagulation
.phosphate ion binding
.signaling adaptor activity
.signal transducer activity
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 68 2
2014-09-19protein level
1 54 2
2014-05-27protein level
1 54 2
2014-02-25protein level
1 54 2
2013-12-09protein level
1 41 2
2013-11-01protein level
1 38 2
2013-09-12protein level
1 38 2
2013-08-17protein level
1 38 2
2013-07-15protein level
1 28 2
2013-06-11protein level
1 28 2
2013-02-12protein level
1 20 1
2012-12-20protein level
1 15 1
2012-10-30protein level
1 21 1
2012-10-07protein level
1 21 1
2012-08-24protein level
1 20 1
2012-07-28protein level
1 20 1
2012-06-08protein level
1 22 1
2012-05-07protein level
1 20 1
2012-04-10protein level
1 20 1
2012-01-13protein level
1 14 1
2011-12-20protein level
1 14 1
2011-11-11protein level
1 14 1
2011-08-23protein level
1 14 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UQQ2-1
27 0 0 63185.4028
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7879749,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-7879749,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
3 EBI-7879749,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
4 EBI-7879749,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood40
bone111
bone marrow20
brain20
cervix41
connective tissue46
embryonic tissue32
eye28
heart67
intestine30
kidney28
liver43
lung50
lymph22
lymph node55
mammary gland59
mouth15
muscle47
nerve64
ovary29
pancreas28
placenta21
salivary gland49
skin109
spleen168
testis18
thymus12
thyroid64
trachea19
uterus34
vascular116
Health State
TissuesTPM*
normal38
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma60
colorectal tumor26
germ cell tumor34
glioma83
head and neck tumor29
kidney tumor29
leukemia95
liver tumor83
lung tumor68
lymphoma13
non-neoplasia51
ovarian tumor39
pancreatic tumor47
primitive neuroectodermal tumor of the CNS23
skin tumor143
soft tissue/muscle tissue tumor47
uterine tumor33
Developmental Stage
TissuesTPM*
adult33
embryoid body14
blastocyst65
fetus62
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18.4
adrenal gland10.8
appendix20
bone marrow31.5
cerebral cortex6.2
colon11
duodenum7.1
esophagus7.1
gallbladder19.1
heart muscle13.5
kidney6.8
liver10.1
lung18.8
lymph node19.4
ovary4.1
pancreas4.5
placenta17.7
prostate5.5
salivary gland3.6
skin2.7
small intestine8.1
spleen32.7
stomach7
testis10.5
thyroid gland9.4
urinary bladder16.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
colonHigh
duodenumLow
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderLow
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasLow
parathyroid glandLow
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(%222100, phenotype) Diabetes mellitus, insulin-dependent; IDDMOMIM
2(*605093, gene) Sh2b adaptor protein 3; SH2B3OMIM
3(%612011, phenotype) Celiac disease, susceptibility to, 13; CELIAC13OMIM


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