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> Protein (NX_Q9Y217)
Protein (NX_Q9Y217)
Protein
Gene SymbolMTMR6 to neXtProt (NX_Q9Y217)
DescriptionMyotubularin-related protein 6
Chromosome13
Location13q12.13 (25802307 ~ 25862147) to Ensembl
Sequene Features : Isoforms 2, Variants 92, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.potassium ion transmembrane transport
.phosphatidylinositol dephosphorylation
.small molecule metabolic process
  + 4 more...
.phosphatidylinositol phosphate phosphatase activity
.calcium-activated potassium channel activity
.protein tyrosine phosphatase activity
.protein serine/threonine phosphatase activity
.cytosol
.cytoplasm
.nuclear envelope
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 92 7
2014-09-19protein level
2 80 7
2014-05-27protein level
2 80 7
2014-02-25protein level
2 79 7
2013-12-09protein level
2 68 7
2013-11-01protein level
2 64 6
2013-09-12protein level
2 64 6
2013-08-17protein level
2 64 6
2013-07-15protein level
2 43 4
2013-06-11protein level
2 43 4
2013-02-12protein level
2 23 4
2012-12-20protein level
2 26 4
2012-10-30protein level
2 26 4
2012-10-07protein level
2 26 3
2012-08-24protein level
2 18 3
2012-07-28protein level
2 18 3
2012-06-08protein level
2 25 3
2012-05-07protein level
2 24 3
2012-04-10protein level
2 24 3
2012-01-13protein level
2 19 3
2011-12-20protein level
2 19 3
2011-11-11protein level
2 19 3
2011-08-23protein level
2 19 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y217-1
6 27 2 71921.9682
NX_Q9Y217-2
1 27 2 63701.8447
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-766064,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-766064,EBI-372942 NMI  
  .regulation of nucleic acid-templated transcription
.JAK-STAT cascade
.inflammatory response
.transcription from RNA polymerase II promoter
.transcription cofactor activity .cytoplasm
.nucleoplasm
3 EBI-766064,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
4 EBI-766064,EBI-744593 MTMR9  
  .N/A .enzyme regulator activity .cytoplasm
5 EBI-766064,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder100
blood24
bone69
bone marrow61
brain108
connective tissue26
embryonic tissue37
eye57
intestine21
kidney56
liver38
lung44
lymph22
lymph node122
mammary gland6
mouth105
muscle28
ovary19
pancreas46
parathyroid48
pharynx49
placenta42
prostate36
salivary gland98
skin14
spleen18
testis163
thymus100
trachea289
uterus86
vascular38
Health State
TissuesTPM*
normal66
bladder carcinoma227
chondrosarcoma48
colorectal tumor8
germ cell tumor34
glioma18
head and neck tumor52
kidney tumor29
leukemia42
liver tumor41
lung tumor38
lymphoma13
non-neoplasia31
ovarian tumor26
pancreatic tumor47
primitive neuroectodermal tumor of the CNS55
prostate cancer38
retinoblastoma86
skin tumor23
soft tissue/muscle tissue tumor31
uterine tumor55
Developmental Stage
TissuesTPM*
adult37
embryoid body14
blastocyst32
fetus53
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.3
adrenal gland18.2
appendix14.2
bone marrow16.1
cerebral cortex16
colon10.7
duodenum7.4
esophagus10.9
gallbladder13
heart muscle11.9
kidney11.5
liver6.2
lung11.2
lymph node13.5
ovary8.4
pancreas5.8
placenta9.1
prostate11.2
salivary gland10.8
skin5.9
small intestine7.8
spleen11.3
stomach9.4
testis24.3
thyroid gland14.8
urinary bladder12.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603561, gene) Myotubularin-related protein 6; MTMR6OMIM


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