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> Protein (NX_Q9Y223)
Protein (NX_Q9Y223)
Protein
Gene SymbolGNE to neXtProt (NX_Q9Y223)
DescriptionBifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Chromosome9
Location9p13.3 (36214438 ~ 36277053) to Ensembl
Sequene Features : Isoforms 5, Variants 96, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.carbohydrate phosphorylation
.cellular protein metabolic process
.post-translational protein modification
  + 6 more...
.metal ion binding
.N-acylmannosamine kinase activity
.UDP-N-acetylglucosamine 2-epimerase activity
  + 2 more...
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 96 3
2014-09-19protein level
5 84 3
2014-05-27protein level
5 84 3
2014-02-25protein level
5 82 3
2013-12-09protein level
5 73 3
2013-11-01protein level
5 73 3
2013-09-12protein level
5 73 3
2013-08-17protein level
5 73 3
2013-07-15protein level
5 55 0
2013-06-11protein level
5 55 0
2013-02-12protein level
5 39 0
2012-12-20protein level
5 41 0
2012-10-30protein level
5 42 0
2012-10-07protein level
5 42 0
2012-08-24protein level
5 42 0
2012-07-28protein level
5 42 0
2012-06-08protein level
4 42 0
2012-05-07protein level
4 42 0
2012-04-10protein level
3 42 0
2012-01-13protein level
3 42 0
2011-12-20protein level
3 42 0
2011-11-11protein level
3 42 0
2011-08-23protein level
3 42 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y223-1
0 33 0 79223.8471
NX_Q9Y223-2
2 33 0 83012.6921
NX_Q9Y223-3
3 30 0 78528.6134
NX_Q9Y223-4
1 28 0 71231.7206
NX_Q9Y223-5
0 26 0 66741.4526
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-4291090,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
2 EBI-4291090,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
3 EBI-4291090,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
4 EBI-4291090,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
5 EBI-4291090,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
6 EBI-4291090,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
7 EBI-4291090,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
8 EBI-4291090,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
9 EBI-4291090,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
10 EBI-4291090,EBI-740290 GTPBP3  
  .tRNA modification .GTP binding
.GTPase activity
.mitochondrion
.nucleus
11 EBI-4291090,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
12 EBI-4291090,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
brain13
cervix41
connective tissue13
embryonic tissue14
eye9
intestine30
kidney4
larynx42
liver43
lung20
lymph node11
mammary gland33
mouth120
muscle37
pancreas32
parathyroid97
placenta28
prostate26
skin37
spleen18
stomach10
testis6
thyroid64
trachea405
uterus25
Health State
TissuesTPM*
normal19
bladder carcinoma56
breast (mammary gland) tumor32
chondrosarcoma12
gastrointestinal tumor8
germ cell tumor7
glioma9
head and neck tumor89
liver tumor20
lung tumor9
pancreatic tumor9
prostate cancer9
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor22
Developmental Stage
TissuesTPM*
adult24
blastocyst16
neonate32
fetus23
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.2
adrenal gland9.9
appendix9.7
bone marrow8.8
cerebral cortex9.2
colon36
duodenum4.2
esophagus11.9
gallbladder8.8
heart muscle6.6
kidney9.9
liver46.9
lung7
lymph node7.4
ovary15.1
pancreas5.2
placenta21.9
prostate17.2
salivary gland39.4
skin2
small intestine6.6
spleen6.2
stomach5.3
testis5.9
thyroid gland7.8
urinary bladder10.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#269921, phenotype) SialuriaOMIM
2(#600737, phenotype) Inclusion body myopathy 2, autosomal recessive; IBM2OMIM
3(*603824, gene) Udp-n-acetylglucosamine 2-epimerase/n-acetylmannosamine kinaseOMIM
4(#605820, phenotype) Nonaka myopathy; NMOMIM


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