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> Protein (NX_Q9Y228)
Protein (NX_Q9Y228)
Protein
Gene SymbolTRAF3IP3 to neXtProt (NX_Q9Y228)
DescriptionTRAF3-interacting JNK-activating modulator
Chromosome1
Location1q32.2 (209929377 ~ 209955668) to Ensembl
Sequene Features : Isoforms 3, Variants 78, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .integral component of membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 78 1
2014-09-19protein level
3 58 1
2014-05-27protein level
3 58 1
2014-02-25protein level
3 57 1
2013-12-09protein level
3 52 1
2013-11-01protein level
3 47 1
2013-09-12protein level
3 47 1
2013-08-17protein level
3 47 1
2013-07-15protein level
3 33 1
2013-06-11protein level
3 33 1
2013-02-12protein level
3 20 3
2012-12-20protein level
3 23 3
2012-10-30protein level
3 23 3
2012-10-07protein level
3 23 1
2012-08-24protein level
3 22 1
2012-07-28protein level
3 22 1
2012-06-08protein level
3 24 1
2012-05-07protein level
3 15 1
2012-04-10protein level
3 15 1
2012-01-13protein level
3 8 1
2011-12-20protein level
3 8 1
2011-11-11protein level
3 8 1
2011-08-23protein level
3 8 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y228-1
0 24 0 63586.6448
NX_Q9Y228-2
1 22 0 61336.425
NX_Q9Y228-3
0 14 0 40648.9334
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-765817,EBI-1050964 PSTPIP1  
  .innate immune response
.nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
.signal transduction
  + 3 more...
.N/A .perinuclear region of cytoplasm
.cleavage furrow
.lamellipodium
  + 5 more...
2 EBI-765817,EBI-1046642 STRN  
  .tight junction assembly
.dendrite development
.Wnt signaling pathway
  + 2 more...
.armadillo repeat domain binding
.protein phosphatase 2A binding
.protein complex binding
  + 2 more...
.postsynaptic membrane
.dendritic spine
.neuronal cell body
  + 4 more...
3 EBI-765817,EBI-741415 SSSCA1  
  .cell division
.mitotic nuclear division
.N/A .N/A
4 EBI-765817,EBI-751145 SP100  
  .negative regulation of nucleic acid-templated transcription
.regulation of Fas signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 27 more...
.chromo shadow domain binding
.protein homodimerization activity
.identical protein binding
  + 7 more...
.nuclear periphery
.PML body
.cytoplasm
  + 3 more...
5 EBI-765817,EBI-489887 EMD  
  .cellular response to growth factor stimulus
.regulation of canonical Wnt signaling pathway
.negative regulation of fibroblast proliferation
  + 8 more...
.beta-tubulin binding
.actin binding
.nuclear membrane
.integral component of membrane
.membrane
  + 5 more...
6 EBI-765817,EBI-1053857 STRN3  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription, DNA-templated
.negative regulation of intracellular estrogen receptor signaling pathway
  + 2 more...
.armadillo repeat domain binding
.protein phosphatase 2A binding
.protein complex binding
  + 2 more...
.protein complex
.neuronal cell body
.dendrite
  + 5 more...
7 EBI-765817,EBI-1773588 STRIP1  
  .cortical actin cytoskeleton organization
.regulation of cell morphogenesis
.N/A .extracellular exosome
.cytoplasm
.nucleus
8 EBI-765817,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
9 EBI-765817,EBI-743099 FATE1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum
10 EBI-765817,EBI-5278764 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
11 EBI-765817,EBI-1773646 SIKE1  
  .innate immune response .N/A .cytosol
12 EBI-765817,EBI-749118 WAC  
  .histone H2B conserved C-terminal lysine ubiquitination
.positive regulation of transcription, DNA-templated
.G1 DNA damage checkpoint
  + 5 more...
.chromatin binding
.RNA polymerase II core binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
.nucleus
13 EBI-765817,EBI-928842 NDEL1  
  .neuron projection extension
.neurofilament cytoskeleton organization
.centrosome localization
  + 20 more...
.oligopeptidase activity
.microtubule binding
.neurofilament cytoskeleton
.axon hillock
.cell leading edge
  + 10 more...
14 EBI-765817,EBI-2341518 TRIM36  
  .regulation of cell cycle
.acrosome reaction
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.extracellular exosome
.cytoskeleton
.acrosomal vesicle
15 EBI-765817,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
16 EBI-765817,EBI-713935 MOB4  
  .transport .metal ion binding .perinuclear region of cytoplasm
.dendritic spine
.neuronal cell body
  + 4 more...
17 EBI-765817,EBI-740175 STK24  
  .execution phase of apoptosis
.regulation of axon regeneration
.protein autophosphorylation
  + 13 more...
.metal ion binding
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.extracellular exosome
.membrane
.cytosol
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood351
bone41
bone marrow41
brain9
cervix20
connective tissue80
esophagus99
eye9
heart55
intestine43
kidney23
liver9
lung26
lymph node144
mammary gland13
mouth60
muscle9
pancreas4
pharynx98
pituitary gland60
placenta3
prostate31
spleen636
stomach52
testis22
thymus803
thyroid42
tonsil176
trachea19
uterus25
vascular19
Health State
TissuesTPM*
normal50
adrenal tumor79
breast (mammary gland) tumor21
chondrosarcoma24
esophageal tumor115
gastrointestinal tumor8
germ cell tumor18
head and neck tumor29
leukemia116
lung tumor9
lymphoma110
non-neoplasia72
prostate cancer28
soft tissue/muscle tissue tumor15
uterine tumor55
Developmental Stage
TissuesTPM*
adult21
neonate32
fetus26
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.7
adrenal gland4.9
appendix75.7
bone marrow39.8
cerebral cortex2.6
colon10.6
duodenum13.3
esophagus7.1
gallbladder17.3
heart muscle3.4
kidney4.4
liver3.5
lung17.1
lymph node140
ovary3.3
pancreas1.2
placenta3.2
prostate5.3
salivary gland7.9
skin5
small intestine18.3
spleen86.3
stomach21.3
testis4.7
thyroid gland3
urinary bladder25.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608255, gene) Traf3-interacting protein 3; TRAF3IP3OMIM


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