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> Protein (NX_Q9Y253)
Protein (NX_Q9Y253)
Protein
Gene SymbolPOLH to neXtProt (NX_Q9Y253)
DescriptionDNA polymerase eta
Chromosome6
Location6p21.1 (43543887 ~ 43586701) to Ensembl
Sequene Features : Isoforms 2, Variants 96, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.error-free translesion synthesis
.translesion synthesis
.response to UV-C
  + 5 more...
.metal ion binding
.DNA-directed DNA polymerase activity
.damaged DNA binding
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 96 4
2014-09-19protein level
2 82 4
2014-05-27protein level
2 82 6
2014-02-25protein level
2 78 6
2013-12-09protein level
2 62 6
2013-11-01protein level
2 60 6
2013-09-12protein level
2 60 6
2013-08-17protein level
2 60 6
2013-07-15protein level
2 39 6
2013-06-11protein level
2 39 6
2013-02-12protein level
2 26 8
2012-12-20protein level
2 25 8
2012-10-30protein level
2 30 8
2012-10-07protein level
2 30 6
2012-08-24protein level
2 30 6
2012-07-28protein level
2 30 2
2012-06-08protein level
2 33 2
2012-05-07protein level
2 29 2
2012-04-10protein level
2 29 2
2012-01-13protein level
2 28 2
2011-12-20protein level
2 28 2
2011-11-11protein level
2 28 2
2011-08-23protein level
2 28 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y253-1
15 18 0 78363.4476
NX_Q9Y253-2
1 18 0 46253.5881
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2827270,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
2 EBI-2827270,EBI-79792 BRCA2  
  .centrosome duplication
.replication fork protection
.positive regulation of mitotic cell cycle
  + 23 more...
.gamma-tubulin binding
.H4 histone acetyltransferase activity
.H3 histone acetyltransferase activity
  + 2 more...
.protein complex
.BRCA2-MAGE-D1 complex
.secretory granule
  + 4 more...
3 EBI-2827270,EBI-1222653 PALB2  
  .negative regulation of apoptotic process
.post-anal tail morphogenesis
.organ morphogenesis
  + 5 more...
.DNA binding .nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
blood16
bone13
bone marrow61
brain20
cervix20
connective tissue13
embryonic tissue14
eye19
heart33
intestine30
kidney52
larynx85
liver24
lung8
lymph383
lymph node211
mammary gland26
mouth90
pancreas14
placenta7
skin52
stomach41
testis48
thymus87
thyroid42
tonsil58
trachea115
uterus30
vascular116
Health State
TissuesTPM*
normal28
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma24
colorectal tumor26
gastrointestinal tumor50
germ cell tumor30
head and neck tumor59
kidney tumor29
leukemia52
liver tumor41
lymphoma235
non-neoplasia10
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
retinoblastoma21
skin tumor39
uterine tumor55
Developmental Stage
TissuesTPM*
adult20
embryoid body14
neonate96
fetus17
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.3
adrenal gland4.1
appendix7.1
bone marrow2.1
cerebral cortex3.6
colon6.2
duodenum3.6
esophagus6
gallbladder5.7
heart muscle3.3
kidney4.7
liver3.2
lung8
lymph node13.8
ovary5.2
pancreas3
placenta3.6
prostate5
salivary gland3.1
skin8.2
small intestine4.1
spleen6.2
stomach4.5
testis11.2
thyroid gland8.5
urinary bladder8.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#278750, phenotype) Xeroderma pigmentosum, variant type; XPVOMIM
2(*603968, gene) Polymerase, dna, eta; POLHOMIM


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