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> Protein (NX_Q9Y297)
Protein (NX_Q9Y297)
Protein
Gene SymbolBTRC to neXtProt (NX_Q9Y297)
DescriptionF-box/WD repeat-containing protein 1A
Chromosome10
Location10q24.32 (103113820 ~ 103317078) to Ensembl
Sequene Features : Isoforms 2, Variants 71, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to organic cyclic compound
.regulation of proteasomal protein catabolic process
.branching involved in mammary gland duct morphogenesis
  + 28 more...
.ligase activity
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.cytosol
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 71 0
2014-09-19protein level
2 60 0
2014-05-27protein level
2 60 0
2014-02-25protein level
2 60 0
2013-12-09protein level
2 51 0
2013-11-01protein level
2 48 0
2013-09-12protein level
2 48 0
2013-08-17protein level
2 48 0
2013-07-15protein level
2 34 0
2013-06-11protein level
2 34 0
2013-02-12protein level
2 15 0
2012-12-20protein level
2 15 0
2012-10-30protein level
2 16 0
2012-10-07protein level
2 16 0
2012-08-24protein level
2 14 0
2012-07-28protein level
2 14 0
2012-06-08protein level
2 15 0
2012-05-07protein level
2 8 0
2012-04-10protein level
2 8 0
2012-01-13protein level
2 4 0
2011-12-20protein level
2 4 0
2011-11-11protein level
2 4 0
2011-08-23protein level
2 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y297-1
2 21 10 68822.2411
NX_Q9Y297-2
0 21 10 65007.4753
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-307461,EBI-624237 TACC1  
  .cell division
.regulation of microtubule-based process
.interkinetic nuclear migration
  + 5 more...
.N/A .intermediate filament cytoskeleton
.microtubule cytoskeleton
.microtubule organizing center
  + 2 more...
2 EBI-307461,EBI-1045459 SNAI1  
  .regulation of tight junction assembly
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.Notch signaling involved in heart development
  + 16 more...
.metal ion binding
.kinase binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleus
3 EBI-307461,EBI-492498 ATF4  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of oxidative stress-induced neuron death
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  + 21 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 9 more...
.CHOP-ATF4 complex
.ATF1-ATF4 transcription factor complex
.ATF4-CREB1 transcription factor complex
  + 8 more...
4 EBI-307461,EBI-914695 WEE1  
  .regulation of cell cycle
.cell division
.neuron projection morphogenesis
  + 7 more...
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.magnesium ion binding
.cytoplasm
.nucleoplasm
.nucleus
5 EBI-307461,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
6 EBI-307461,EBI-307486 SKP1  
  .regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
.innate immune response
  + 11 more...
.ubiquitin-protein transferase activity .extracellular exosome
.Cul7-RING ubiquitin ligase complex
.SCF ubiquitin ligase complex
  + 2 more...
7 EBI-307461,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
8 EBI-307461,EBI-492564 MAP2K1  
  .regulation of early endosome to late endosome transport
.activation of mitophagy in response to mitochondrial depolarization
.cellular senescence
  + 55 more...
.protein N-terminus binding
.protein serine/threonine kinase activator activity
.protein C-terminus binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.perikaryon
  + 15 more...
9 EBI-307461,EBI-357481 DLG1  
  .regulation of sodium ion transmembrane transport
.receptor localization to synapse
.positive regulation of establishment of protein localization to plasma membrane
  + 38 more...
.L27 domain binding
.ion channel binding
.ionotropic glutamate receptor binding
  + 8 more...
.MPP7-DLG1-LIN7 complex
.extracellular exosome
.perinuclear region of cytoplasm
  + 26 more...
10 EBI-307461,EBI-359390 CUL1  
  .intrinsic apoptotic signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 17 more...
.N/A .Parkin-FBXW7-Cul1 ubiquitin ligase complex
.cullin-RING ubiquitin ligase complex
.SCF ubiquitin ligase complex
  + 2 more...
11 EBI-307461,EBI-716247 NEDD8  
  .protein neddylation
.response to organic cyclic compound
.anatomical structure morphogenesis
  + 6 more...
.ubiquitin protein ligase binding .extracellular exosome
.cytosol
.nucleus
12 EBI-307461,EBI-726369 NFE2  
  .positive regulation of peptidyl-lysine acetylation
.labyrinthine layer blood vessel development
.positive regulation of transcription, DNA-templated
  + 10 more...
.WW domain binding
.protein N-terminus binding
.sequence-specific DNA binding
  + 2 more...
.PML body
.actin cytoskeleton
.cytoplasm
  + 2 more...
13 EBI-307461,EBI-747793 ZC3H12A  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to lipopolysaccharide
.positive regulation of fat cell differentiation
  + 12 more...
.metal ion binding
.endonuclease activity
.plasma membrane
.cytoplasm
.nucleoplasm
14 EBI-307461,EBI-367390 RASSF5  
  .regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
15 EBI-307461,EBI-720828 TRIM9  
  .negative regulation of calcium ion-dependent exocytosis
.proteasome-mediated ubiquitin-dependent protein catabolic process
.negative regulation of SNARE complex assembly
.synaptic vesicle exocytosis
.protein homodimerization activity
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.dendrite
.cell junction
.synaptic vesicle
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland151
bladder33
blood24
bone83
brain64
connective tissue33
embryonic tissue61
esophagus49
eye62
heart100
intestine17
kidney37
lung29
lymph22
lymph node66
mammary gland72
mouth30
muscle122
ovary9
pancreas14
parathyroid242
pharynx24
pituitary gland60
placenta17
prostate36
skin14
stomach10
testis55
thymus12
thyroid21
trachea77
uterus47
vascular19
Health State
TissuesTPM*
normal63
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor107
chondrosarcoma96
colorectal tumor26
esophageal tumor57
germ cell tumor56
glioma46
head and neck tumor14
kidney tumor58
leukemia10
lymphoma13
non-neoplasia31
ovarian tumor13
pancreatic tumor9
prostate cancer28
retinoblastoma107
soft tissue/muscle tissue tumor63
uterine tumor55
Developmental Stage
TissuesTPM*
adult43
embryoid body42
blastocyst65
fetus138
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.8
adrenal gland9.3
appendix4.9
bone marrow4.5
cerebral cortex23.6
colon5.1
duodenum3.8
esophagus17.1
gallbladder10.6
heart muscle16.1
kidney8.7
liver3.8
lung6.2
lymph node5.6
ovary14.4
pancreas4.6
placenta10.3
prostate9.8
salivary gland5.5
skin7.4
small intestine7
spleen6.6
stomach5.5
testis21.8
thyroid gland19.7
urinary bladder11.6
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisLow
esophagusMedium
fallopian tubeLow
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Medium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603482, gene) Beta-transducin repeat-containing protein; BTRCOMIM


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