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> Protein (NX_Q9Y2D8)
Protein (NX_Q9Y2D8)
Protein
Gene SymbolSSX2IP to neXtProt (NX_Q9Y2D8)
DescriptionAfadin- and alpha-actinin-binding protein
Chromosome1
Location1p22.3 (85109390 ~ 85156486) to Ensembl
Sequene Features : Isoforms 3, Variants 67, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 67 11
2014-09-19protein level
3 52 11
2014-05-27protein level
3 52 11
2014-02-25protein level
3 52 11
2013-12-09protein level
3 36 11
2013-11-01protein level
3 35 9
2013-09-12protein level
3 35 9
2013-08-17protein level
3 35 9
2013-07-15protein level
3 24 8
2013-06-11protein level
3 24 8
2013-02-12protein level
2 5 21
2012-12-20protein level
2 5 21
2012-10-30protein level
2 15 21
2012-10-07protein level
2 15 11
2012-08-24protein level
2 13 11
2012-07-28protein level
2 13 11
2012-06-08protein level
2 16 11
2012-05-07protein level
2 16 11
2012-04-10protein level
2 16 11
2012-01-13protein level
2 7 11
2011-12-20protein level
2 7 11
2011-11-11protein level
2 7 8
2011-08-23protein level
2 7 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y2D8-1
0 30 0 71191.2242
NX_Q9Y2D8-2
0 28 0 65452.631
NX_Q9Y2D8-3
0 28 0 68230.8901
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2212028,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
2 EBI-2212028,EBI-1210440 ZSCAN12  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
3 EBI-2212028,EBI-351267 ABLIM3  
  .positive regulation of protein targeting to mitochondrion
.positive regulation of transcription from RNA polymerase II promoter
.cilium assembly
  + 4 more...
.zinc ion binding .lamellipodium
.cytoplasm
.stress fiber
4 EBI-2212028,EBI-741602 TRIM37  
  .aggresome assembly
.protein autoubiquitination
.positive regulation of NF-kappaB transcription factor activity
  + 7 more...
.ubiquitin protein ligase activity
.protein homodimerization activity
.ubiquitin protein ligase binding
  + 5 more...
.perinuclear region of cytoplasm
.aggresome
.cytosol
  + 2 more...
5 EBI-2212028,EBI-373403 TOP3B  
  .chromosome segregation
.DNA topological change
.poly(A) RNA binding
.DNA topoisomerase type I activity
.DNA topoisomerase activity
.DNA binding
.nucleoplasm
.nucleus
.condensed chromosome
6 EBI-2212028,EBI-1757866 MOS  
  .negative regulation of metaphase/anaphase transition of meiotic cell cycle
.establishment of meiotic spindle orientation
.protein autophosphorylation
  + 6 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.cytoplasm
7 EBI-2212028,EBI-10177272 ZNF250  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
8 EBI-2212028,EBI-1640965 ZNF3  
  .leukocyte activation
.cell differentiation
.multicellular organismal development
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.nucleus
9 EBI-2212028,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
10 EBI-2212028,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
11 EBI-2212028,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
12 EBI-2212028,EBI-747693 NAA10  
  .N-terminal peptidyl-glutamic acid acetylation
.N-terminal peptidyl-serine acetylation
.internal protein amino acid acetylation
  + 2 more...
.peptide-glutamate-N-acetyltransferase activity
.peptide-serine-N-acetyltransferase activity
.N-acetyltransferase activity
.NatA complex
.cytosolic ribosome
.membrane
  + 4 more...
13 EBI-2212028,EBI-741406 CCNH  
  .positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of gene expression, epigenetic
  + 20 more...
.cyclin-dependent protein serine/threonine kinase regulator activity
.kinase activity
.TFIIK complex
.cyclin-dependent protein kinase activating kinase holoenzyme complex
.holo TFIIH complex
  + 2 more...
14 EBI-2212028,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
15 EBI-2212028,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
16 EBI-2212028,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
17 EBI-2212028,EBI-540834 WDR5  
  .histone H3-K4 methylation
.histone H4-K16 acetylation
.histone H4-K8 acetylation
  + 6 more...
.N/A .MLL1 complex
.Set1C/COMPASS complex
.histone methyltransferase complex
  + 4 more...
18 EBI-2212028,EBI-517127 XIAP  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.positive regulation of protein linear polyubiquitination
.intrinsic apoptotic signaling pathway
  + 15 more...
.ubiquitin protein ligase activity
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
19 EBI-2212028,EBI-2339219 EHHADH  
  .fatty acid beta-oxidation
.internal protein amino acid acetylation
.coenzyme binding
.enzyme binding
.receptor binding
  + 3 more...
.cytosol
.peroxisome
.mitochondrion
20 EBI-2212028,EBI-10181260 GOLGA8F  
  .N/A .N/A .Golgi apparatus
21 EBI-2212028,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
22 EBI-2212028,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
23 EBI-2212028,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
24 EBI-2212028,EBI-73473 EIF4A2  
  .negative regulation of RNA-directed RNA polymerase activity
.cellular protein metabolic process
.cytokine-mediated signaling pathway
  + 8 more...
.poly(A) RNA binding
.ATPase activity
.ATP binding
  + 3 more...
.perinuclear region of cytoplasm
.eukaryotic translation initiation factor 4F complex
.cytosol
.nucleolus
25 EBI-2212028,EBI-741421 PCM1  
  .neuronal stem cell maintenance
.positive regulation of intracellular protein transport
.protein localization to centrosome
  + 12 more...
.identical protein binding .protein complex
.ciliary basal body
.centriolar satellite
  + 6 more...
26 EBI-2212028,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
27 EBI-2212028,EBI-6657923 ZRSR2  
  .RNA splicing
.mRNA splicing, via spliceosome
.spliceosomal complex assembly
.metal ion binding
.pre-mRNA 3'-splice site binding
.nucleotide binding
.U12-type spliceosomal complex
28 EBI-2212028,EBI-2555767 ZNF124  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
29 EBI-2212028,EBI-2210673 SSX2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.nucleic acid binding .nucleus
30 EBI-2212028,EBI-602382 PKN1  
  .regulation of cell motility
.histone H3-T11 phosphorylation
.epithelial cell migration
  + 7 more...
.androgen receptor binding
.Rac GTPase binding
.histone deacetylase binding
  + 10 more...
.cleavage furrow
.midbody
.cytoplasmic membrane-bounded vesicle
  + 6 more...
31 EBI-2212028,EBI-2866142 FAM214A  
  .N/A .N/A .N/A
32 EBI-2212028,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
33 EBI-2212028,EBI-10240849 ZNF792  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
34 EBI-2212028,EBI-6447954 TTC23  
  .N/A .N/A .N/A
35 EBI-2212028,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
36 EBI-2212028,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
37 EBI-2212028,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
38 EBI-2212028,EBI-10269566 MORN4  
  .N/A .N/A .N/A
39 EBI-2212028,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
40 EBI-2212028,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
41 EBI-2212028,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
42 EBI-2212028,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
43 EBI-2212028,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
44 EBI-2212028,EBI-2513715 MRPL53  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 2 more...
.N/A .ribosome
.mitochondrial inner membrane
45 EBI-2212028,EBI-5278764 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
46 EBI-2212028,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
47 EBI-2212028,EBI-741729 FRMD6  
  .cellular protein localization
.regulation of actin filament-based process
.apical constriction
.N/A .apical junction complex
.plasma membrane
.cytoskeleton
.cytoplasm
48 EBI-2212028,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
49 EBI-2212028,EBI-10295431 SSX3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.nucleic acid binding .nucleus
50 EBI-2212028,EBI-2568609 FAM64A  
  .cell division
.mitotic nuclear division
.N/A .cytoplasm
.nucleolus
.nucleus
51 EBI-2212028,EBI-745392 SYT17  
  .positive regulation of dendrite extension
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.clathrin binding
.syntaxin binding
.calcium-dependent phospholipid binding
.calcium ion binding
.plasma membrane
.trans-Golgi network
52 EBI-2212028,EBI-744935 C20orf195  
  .N/A .N/A .extracellular exosome
53 EBI-2212028,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
54 EBI-2212028,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
55 EBI-2212028,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
.nucleus
56 EBI-2212028,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
57 EBI-2212028,EBI-715611 INO80B  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin remodeling
  + 2 more...
.metal ion binding .Ino80 complex
.plasma membrane
.cytoplasm
  + 3 more...
58 EBI-2212028,EBI-740204 C11orf54  
  .metabolic process .hydrolase activity, acting on ester bonds
.zinc ion binding
.extracellular exosome
.nucleus
59 EBI-2212028,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
60 EBI-2212028,EBI-741626 FAM124B  
  .N/A .N/A .N/A
61 EBI-2212028,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
62 EBI-2212028,EBI-2339898 FANCL  
  .regulation of cell proliferation
.gamete generation
.cellular response to DNA damage stimulus
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.Fanconi anaemia nuclear complex
.cytoplasm
.nucleoplasm
.nuclear envelope
63 EBI-2212028,EBI-743375 CHCHD3  
  .mitochondrial fusion
.inner mitochondrial membrane organization
.negative regulation of transcription from RNA polymerase II promoter
.protein complex scaffold
.phosphatase binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
64 EBI-2212028,EBI-739890 KLHL42  
  .cell division
.proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of microtubule-based process
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.spindle
.cytoplasm
65 EBI-2212028,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
66 EBI-2212028,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
67 EBI-2212028,EBI-10320765 POLL  
  .somatic hypermutation of immunoglobulin genes
.nucleotide-excision repair
.DNA replication
.metal ion binding
.lyase activity
.DNA-directed DNA polymerase activity
.DNA binding
.nucleus
68 EBI-2212028,EBI-716098 NOL12  
  .N/A .poly(A) RNA binding
.rRNA binding
.nucleolus
69 EBI-2212028,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
70 EBI-2212028,EBI-719554 DRG1  
  .multicellular organismal development
.transcription, DNA-templated
.identical protein binding
.transcription factor binding
.GTP binding
.membrane
.polysome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
blood16
bone111
bone marrow20
brain56
connective tissue20
embryonic tissue46
eye67
heart11
intestine17
kidney52
larynx85
liver34
lung50
lymph node44
mammary gland13
muscle56
ovary29
pancreas23
parathyroid48
pituitary gland60
placenta21
prostate26
skin28
stomach10
testis112
thymus50
thyroid42
trachea19
uterus25
vascular19
Health State
TissuesTPM*
normal60
breast (mammary gland) tumor21
chondrosarcoma120
colorectal tumor17
gastrointestinal tumor8
germ cell tumor45
glioma55
head and neck tumor22
leukemia31
liver tumor31
lung tumor19
lymphoma41
non-neoplasia20
ovarian tumor39
pancreatic tumor19
prostate cancer28
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor7
uterine tumor44
Developmental Stage
TissuesTPM*
adult35
embryoid body42
neonate32
fetus66
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.8
adrenal gland3.6
appendix6.3
bone marrow11.3
cerebral cortex27.9
colon7.9
duodenum41.8
esophagus7.2
gallbladder10
heart muscle7.5
kidney15
liver7.4
lung3.9
lymph node5.9
ovary2.2
pancreas3.2
placenta4.9
prostate11.8
salivary gland5
skin6.2
small intestine26.8
spleen4.9
stomach7.4
testis110.7
thyroid gland8.2
urinary bladder7.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608690, gene) Ssx2-interacting protein; SSX2IPOMIM


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