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> Protein (NX_Q9Y2H0)
Protein (NX_Q9Y2H0)
Protein
Gene SymbolDLGAP4 to neXtProt (NX_Q9Y2H0)
DescriptionDisks large-associated protein 4
Chromosome20
Location20q11.23 (34894258 ~ 35157040) to Ensembl
Sequene Features : Isoforms 3, Variants 157, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.signaling .N/A .synapse
.membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 157 5
2014-09-19protein level
3 109 5
2014-05-27protein level
3 109 5
2014-02-25protein level
3 109 5
2013-12-09protein level
3 88 5
2013-11-01protein level
3 82 5
2013-09-12protein level
3 82 9
2013-08-17protein level
3 82 9
2013-07-15protein level
3 55 9
2013-06-11protein level
3 55 9
2013-02-12protein level
3 30 24
2012-12-20protein level
3 31 24
2012-10-30protein level
3 32 24
2012-10-07protein level
3 32 10
2012-08-24protein level
3 29 10
2012-07-28protein level
3 29 10
2012-06-08protein level
3 30 10
2012-05-07protein level
3 23 10
2012-04-10protein level
3 23 10
2012-01-13protein level
3 19 10
2011-12-20protein level
3 19 10
2011-11-11protein level
3 19 10
2011-08-23protein level
3 19 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y2H0-1
3 39 1 107500.8903
NX_Q9Y2H0-2
0 43 1 107945.1447
NX_Q9Y2H0-3
2 20 1 49447.4884
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-722139,EBI-719094 BIN1  
  .regulation of cell cycle arrest
.lipid tube assembly
.positive regulation of astrocyte differentiation
  + 8 more...
.RNA polymerase binding
.tau protein binding
.identical protein binding
.lipid tube
.cerebellar mossy fiber
.axon terminus
  + 12 more...
2 EBI-722139,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
3 EBI-722139,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
4 EBI-722139,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland151
ascites225
bladder66
blood32
bone167
bone marrow61
brain186
cervix144
connective tissue100
embryonic tissue155
esophagus99
eye158
heart55
intestine77
kidney109
liver24
lung116
lymph22
lymph node22
mammary gland59
mouth196
muscle47
nerve128
ovary88
pancreas234
placenta84
prostate89
salivary gland98
skin246
spleen187
stomach135
testis142
thymus213
thyroid85
trachea154
umbilical cord145
uterus124
vascular96
Health State
TissuesTPM*
normal120
adrenal tumor237
breast (mammary gland) tumor96
cervical tumor144
chondrosarcoma132
colorectal tumor35
esophageal tumor57
gastrointestinal tumor126
germ cell tumor197
glioma326
head and neck tumor134
kidney tumor43
leukemia52
liver tumor52
lung tumor58
lymphoma27
non-neoplasia113
ovarian tumor39
pancreatic tumor409
primitive neuroectodermal tumor of the CNS149
prostate cancer86
retinoblastoma43
skin tumor191
soft tissue/muscle tissue tumor55
uterine tumor88
Developmental Stage
TissuesTPM*
adult99
embryoid body242
blastocyst162
neonate354
fetus202
infant255
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue28.5
adrenal gland25.5
appendix25.4
bone marrow5.1
cerebral cortex33.5
colon19
duodenum20.7
esophagus21.5
gallbladder29.5
heart muscle32.6
kidney15.6
liver10.7
lung32
lymph node16.9
ovary26.6
pancreas24.4
placenta28.1
prostate26.8
salivary gland23
skin37.3
small intestine21.6
spleen28.2
stomach22.1
testis28.1
thyroid gland25
urinary bladder33.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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