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> Protein (NX_Q9Y2J4)
Protein (NX_Q9Y2J4)
Protein
Gene SymbolAMOTL2 to neXtProt (NX_Q9Y2J4)
DescriptionAngiomotin-like protein 2
Chromosome3
Location3q22.2 (134074716 ~ 134094321) to Ensembl
Sequene Features : Isoforms 4, Variants 92, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 92 9
2014-09-19protein level
4 76 9
2014-05-27protein level
4 76 9
2014-02-25protein level
4 75 9
2013-12-09protein level
4 58 9
2013-11-01protein level
4 58 9
2013-09-12protein level
4 58 9
2013-08-17protein level
4 58 9
2013-07-15protein level
4 40 9
2013-06-11protein level
4 40 9
2013-02-12protein level
4 28 12
2012-12-20protein level
4 27 12
2012-10-30protein level
4 32 12
2012-10-07protein level
4 32 3
2012-08-24protein level
4 28 3
2012-07-28protein level
3 27 2
2012-06-08protein level
3 28 2
2012-05-07protein level
3 28 2
2012-04-10protein level
3 28 2
2012-01-13protein level
3 9 2
2011-12-20protein level
3 9 2
2011-11-11protein level
3 9 1
2011-08-23protein level
3 9 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y2J4-1
0 32 0 85712.3038
NX_Q9Y2J4-2
0 32 0 85783.3407
NX_Q9Y2J4-3
1 31 0 85428.1451
NX_Q9Y2J4-4
3 32 0 91761.3635
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10187270,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
2 EBI-10187270,EBI-744408 RNF40  
  .positive regulation of histone H2B ubiquitination
.negative regulation of mRNA polyadenylation
.histone H2B ubiquitination
  + 2 more...
.protein homodimerization activity
.ubiquitin protein ligase binding
.ligase activity
  + 3 more...
.neuron projection
.HULC complex
.membrane
  + 3 more...
3 EBI-10187270,EBI-1055693 RAD51D  
  .strand invasion
.reciprocal meiotic recombination
.DNA repair
  + 2 more...
.gamma-tubulin binding
.DNA-dependent ATPase activity
.ATP binding
  + 2 more...
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.centrosome
.cytoplasm
  + 3 more...
4 EBI-10187270,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
5 EBI-10187270,EBI-740037 ZBED1  
  .metabolic process .metal ion binding
.transposase activity
.DNA binding
.nuclear chromosome
6 EBI-10187270,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
7 EBI-10187270,EBI-286285 THRA  
  .negative regulation of DNA-templated transcription, initiation
.Type I pneumocyte differentiation
.regulation of lipid catabolic process
  + 22 more...
.thyroid hormone binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 9 more...
.cytosol
.nucleoplasm
.nucleus
8 EBI-10187270,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
9 EBI-10187270,EBI-359720 PSMC3  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
  + 26 more...
.proteasome-activating ATPase activity
.TBP-class protein binding
.ATPase activity
  + 3 more...
.perinuclear region of cytoplasm
.cytosolic proteasome complex
.nuclear proteasome complex
  + 8 more...
10 EBI-10187270,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
11 EBI-10187270,EBI-751145 SP100  
  .negative regulation of nucleic acid-templated transcription
.regulation of Fas signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 27 more...
.chromo shadow domain binding
.protein homodimerization activity
.identical protein binding
  + 7 more...
.nuclear periphery
.PML body
.cytoplasm
  + 3 more...
12 EBI-10187270,EBI-10173632 DDIT3  
  .negative regulation of determination of dorsal identity
.positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
  + 32 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.leucine zipper domain binding
  + 8 more...
.CHOP-ATF3 complex
.CHOP-ATF4 complex
.CHOP-C/EBP complex
  + 5 more...
13 EBI-10187270,EBI-742094 KRT20  
  .regulation of protein secretion
.intermediate filament organization
.cellular response to stress
.apoptotic process
.structural constituent of cytoskeleton .intermediate filament
.cytoplasm
14 EBI-10187270,EBI-4312072 GSTM5  
  .glutathione derivative biosynthetic process
.small molecule metabolic process
.xenobiotic metabolic process
.glutathione metabolic process
.glutathione transferase activity .cytosol
15 EBI-10187270,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
16 EBI-10187270,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
17 EBI-10187270,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
18 EBI-10187270,EBI-349105 DYNLL1  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of phosphorylation
  + 15 more...
.nitric-oxide synthase regulator activity
.motor activity
.ciliary tip
.mitotic spindle
.primary cilium
  + 11 more...
19 EBI-10187270,EBI-10220734 GNG5  
  .cellular response to glucagon stimulus
.small molecule metabolic process
.synaptic transmission
  + 3 more...
.PDZ domain binding
.signal transducer activity
.GTPase activity
.extracellular exosome
.membrane
.plasma membrane
.heterotrimeric G-protein complex
20 EBI-10187270,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
21 EBI-10187270,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
22 EBI-10187270,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
23 EBI-10187270,EBI-749285 RALBP1  
  .regulation of small GTPase mediated signal transduction
.positive regulation of GTPase activity
.regulation of GTPase activity
  + 5 more...
.Rac GTPase binding
.ATPase activity, coupled to movement of substances
.Ral GTPase binding
  + 2 more...
.membrane
.cytosol
24 EBI-10187270,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
25 EBI-10187270,EBI-3951858 NFIL3  
  .cellular response to interleukin-4
.positive regulation of gene expression
.circadian rhythm
  + 3 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
  + 3 more...
.nucleus
26 EBI-10187270,EBI-5666615 BRMS1L  
  .regulation of growth
.histone deacetylation
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.histone deacetylase binding .Sin3-type complex
27 EBI-10187270,EBI-2372238 RNF20  
  .positive regulation of histone H2B ubiquitination
.negative regulation of mRNA polyadenylation
.positive regulation of transcription, DNA-templated
  + 7 more...
.histone binding
.ubiquitin protein ligase binding
.ligase activity
  + 6 more...
.HULC complex
.nucleolus
.nucleoplasm
  + 2 more...
28 EBI-10187270,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
29 EBI-10187270,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
30 EBI-10187270,EBI-367390 RASSF5  
  .regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
31 EBI-10187270,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
32 EBI-10187270,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
33 EBI-10187270,EBI-413317 SPAG5  
  .regulation of attachment of spindle microtubules to kinetochore
.cell division
.chromosome segregation
  + 2 more...
.N/A .mitotic spindle
.microtubule plus-end
.midbody
  + 7 more...
34 EBI-10187270,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
35 EBI-10187270,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
36 EBI-10187270,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
37 EBI-10187270,EBI-311356 MYO5B  
  .transmembrane transport
.endosome localization
.vesicle-mediated transport
  + 4 more...
.Rab GTPase binding
.ATP binding
.microfilament motor activity
.extracellular exosome
.apical cortex
.protein complex
  + 2 more...
38 EBI-10187270,EBI-766064 MTMR6  
  .potassium ion transmembrane transport
.phosphatidylinositol dephosphorylation
.small molecule metabolic process
  + 4 more...
.phosphatidylinositol phosphate phosphatase activity
.calcium-activated potassium channel activity
.protein tyrosine phosphatase activity
.protein serine/threonine phosphatase activity
.cytosol
.cytoplasm
.nuclear envelope
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
bladder100
bone13
brain151
connective tissue80
ear124
embryonic tissue155
esophagus49
eye62
heart44
intestine25
kidney47
larynx42
liver58
lung50
mammary gland26
ovary19
placenta7
prostate5
skin4
testis2
uterus25
vascular19
Health State
TissuesTPM*
normal95
breast (mammary gland) tumor21
chondrosarcoma48
colorectal tumor26
esophageal tumor57
gastrointestinal tumor33
germ cell tumor170
glioma83
head and neck tumor44
kidney tumor14
liver tumor62
non-neoplasia93
ovarian tumor65
pancreatic tumor19
primitive neuroectodermal tumor of the CNS31
prostate cancer9
retinoblastoma21
uterine tumor33
Developmental Stage
TissuesTPM*
adult71
embryoid body257
blastocyst48
neonate32
fetus82
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue59.8
adrenal gland11
appendix7.5
cerebral cortex22.2
colon8.6
duodenum7.3
esophagus19.9
gallbladder27.5
heart muscle16
kidney34.6
liver12.8
lung35.1
lymph node14
ovary17.5
pancreas12.8
placenta42.4
prostate28.4
salivary gland9.8
skin16.2
small intestine8.2
spleen22
stomach9.6
testis6.2
thyroid gland25.7
urinary bladder21.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614658, gene) Angiomotin-like 2; AMOTL2OMIM


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