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> Protein (NX_Q9Y2R2)
Protein (NX_Q9Y2R2)
Protein
Gene SymbolPTPN22 to neXtProt (NX_Q9Y2R2)
DescriptionTyrosine-protein phosphatase non-receptor type 22
Chromosome1
Location1p13.2 (114356433 ~ 114414381) to Ensembl
Sequene Features : Isoforms 6, Variants 125, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of T cell activation
.negative regulation of T cell receptor signaling pathway
.regulation of B cell receptor signaling pathway
  + 7 more...
.kinase binding
.SH3 domain binding
.protein tyrosine phosphatase activity
.perinuclear region of cytoplasm
.cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 125 11
2014-09-19protein level
6 96 11
2014-05-27protein level
6 96 11
2014-02-25protein level
6 95 11
2013-12-09protein level
6 83 11
2013-11-01protein level
6 77 11
2013-09-12protein level
6 77 10
2013-08-17protein level
6 77 10
2013-07-15protein level
6 43 5
2013-06-11protein level
6 43 5
2013-02-12protein level
6 31 19
2012-12-20protein level
6 29 19
2012-10-30protein level
5 33 16
2012-10-07protein level
5 33 4
2012-08-24protein level
5 23 4
2012-07-28protein level
5 23 4
2012-06-08protein level
5 33 4
2012-05-07protein level
5 33 4
2012-04-10protein level
5 33 4
2012-01-13protein level
5 33 4
2011-12-20protein level
5 33 4
2011-11-11protein level
5 33 4
2011-08-23protein level
5 33 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y2R2-1
0 35 0 91646.5067
NX_Q9Y2R2-2
0 31 0 78719.2379
NX_Q9Y2R2-3
0 32 0 85084.1362
NX_Q9Y2R2-4
0 33 0 88590.8813
NX_Q9Y2R2-5
1 7 0 20918.851
NX_Q9Y2R2-6
2 26 0 75440.7652
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1211241,EBI-1050964 PSTPIP1  
  .innate immune response
.nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
.signal transduction
  + 3 more...
.N/A .perinuclear region of cytoplasm
.cleavage furrow
.lamellipodium
  + 5 more...
2 EBI-1211241,EBI-2483161 SKAP2  
  .B cell activation
.positive regulation of signal transduction
.negative regulation of cell proliferation
  + 2 more...
.SH3/SH2 adaptor activity .plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
3 EBI-1211241,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
4 EBI-1211241,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
5 EBI-1211241,EBI-1165705 CD247  
  .T cell receptor signaling pathway
.regulation of immune response
.regulation of defense response to virus by virus
  + 4 more...
.protein homodimerization activity
.identical protein binding
.transmembrane signaling receptor activity
.alpha-beta T cell receptor complex
.T cell receptor complex
.integral component of membrane
  + 2 more...
6 EBI-1211241,EBI-1211276 ZAP70  
  .T cell migration
.T cell aggregation
.T cell receptor signaling pathway
  + 19 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.T cell receptor complex
.extrinsic component of cytoplasmic side of plasma membrane
.cell-cell junction
  + 4 more...
7 EBI-1211241,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood24
bone marrow61
brain2
connective tissue80
intestine17
lung8
lymph22
lymph node100
mammary gland13
muscle9
pancreas4
pharynx49
prostate5
skin9
spleen18
testis18
thymus138
thyroid21
uterus4
Health State
TissuesTPM*
normal9
breast (mammary gland) tumor21
colorectal tumor26
germ cell tumor7
glioma18
head and neck tumor7
leukemia10
lymphoma27
non-neoplasia51
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer9
skin tumor15
soft tissue/muscle tissue tumor55
Developmental Stage
TissuesTPM*
adult10
neonate32
fetus5
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.8
adrenal gland1.7
appendix12.3
bone marrow23.3
colon4
duodenum6.3
esophagus2.1
gallbladder5.5
liver1.4
lung7
lymph node20.1
prostate1.5
salivary gland1.5
small intestine8.4
spleen11.9
stomach6.7
testis1.9
urinary bladder6.4
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryHigh
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#152700, phenotype) Systemic lupus erythematosus; SLEOMIM
2(#180300, phenotype) Rheumatoid arthritis; RAOMIM
3(%193200, phenotype) Vitiligo-associated multiple autoimmune disease susceptibility 6;OMIM
4(%222100, phenotype) Diabetes mellitus, insulin-dependent; IDDMOMIM
5(*600716, gene) Protein tyrosine phosphatase, nonreceptor-type, 22; PTPN22OMIM


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