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> Protein (NX_Q9Y2W2)
Protein (NX_Q9Y2W2)
Protein
Gene SymbolWBP11 to neXtProt (NX_Q9Y2W2)
DescriptionWW domain-binding protein 11
Chromosome12
Location12p12.3 (14939410 ~ 14956474) to Ensembl
Sequene Features : Isoforms 1, Variants 71, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA splicing
.mRNA processing
.rRNA processing
.WW domain binding
.poly(A) RNA binding
.protein phosphatase type 1 regulator activity
.single-stranded DNA binding
.nuclear speck
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 71 17
2014-09-19protein level
1 53 17
2014-05-27protein level
1 53 17
2014-02-25protein level
1 53 16
2013-12-09protein level
1 42 16
2013-11-01protein level
1 41 15
2013-09-12protein level
1 41 15
2013-08-17protein level
1 41 15
2013-07-15protein level
1 32 15
2013-06-11protein level
1 32 15
2013-02-12protein level
1 9 18
2012-12-20protein level
1 9 18
2012-10-30protein level
1 11 18
2012-10-07protein level
1 11 18
2012-08-24protein level
1 7 18
2012-07-28protein level
1 7 18
2012-06-08protein level
1 10 18
2012-05-07protein level
1 10 18
2012-04-10protein level
1 10 18
2012-01-13protein level
1 8 18
2011-12-20protein level
1 8 18
2011-11-11protein level
1 8 17
2011-08-23protein level
1 8 17
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y2W2-1
25 0 0 69953.7183
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-714455,EBI-713867 PQBP1  
  .regulation of dendrite morphogenesis
.regulation of RNA splicing
.neuron projection development
  + 3 more...
.ribonucleoprotein complex binding
.transcription coactivator activity
.DNA binding
.neuronal ribonucleoprotein granule
.nuclear speck
.cytoplasmic stress granule
  + 3 more...
2 EBI-714455,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
3 EBI-714455,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
4 EBI-714455,EBI-946095 PCBP1  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
.extracellular exosome
.intracellular membrane-bounded organelle
.ribonucleoprotein complex
  + 3 more...
5 EBI-714455,EBI-740653 TESC  
  .protein targeting to plasma membrane
.cellular response to retinoic acid
.protein maturation
  + 10 more...
.protein homodimerization activity
.phosphatase inhibitor activity
.calcium ion binding
  + 2 more...
.ruffle membrane
.lamellipodium
.plasma membrane
  + 4 more...
6 EBI-714455,EBI-3650647 TRAF4  
  .positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder66
blood57
bone69
bone marrow123
brain42
cervix226
connective tissue13
embryonic tissue103
eye95
heart67
intestine64
kidney33
liver43
lung71
lymph135
lymph node55
mammary gland66
mouth45
muscle47
ovary88
pancreas42
pharynx73
pituitary gland60
placenta105
prostate26
skin66
stomach146
testis372
thyroid150
trachea19
uterus77
vascular38
Health State
TissuesTPM*
normal53
adrenal tumor79
breast (mammary gland) tumor96
cervical tumor202
chondrosarcoma36
colorectal tumor97
gastrointestinal tumor135
germ cell tumor148
glioma65
head and neck tumor74
kidney tumor72
leukemia105
liver tumor52
lung tumor38
lymphoma96
non-neoplasia20
ovarian tumor105
pancreatic tumor76
primitive neuroectodermal tumor of the CNS23
prostate cancer48
retinoblastoma236
skin tumor79
soft tissue/muscle tissue tumor119
uterine tumor55
Developmental Stage
TissuesTPM*
adult78
embryoid body42
blastocyst179
fetus44
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue28.6
adrenal gland34.8
appendix33.9
bone marrow52.8
cerebral cortex33
colon30.2
duodenum21.8
esophagus29.5
gallbladder27.9
heart muscle37.9
kidney27.5
liver19.7
lung30.7
lymph node39.7
ovary35.4
pancreas16.3
placenta35.2
prostate30.3
salivary gland23.5
skin27.8
small intestine24.3
spleen32.9
stomach25.6
testis62
thyroid gland35.6
urinary bladder32.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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