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> Protein (NX_Q9Y2X7)
Protein (NX_Q9Y2X7)
Protein
Gene SymbolGIT1 to neXtProt (NX_Q9Y2X7)
DescriptionARF GTPase-activating protein GIT1
Chromosome17
Location17q11.2 (27900487 ~ 27921072) to Ensembl
Sequene Features : Isoforms 3, Variants 53, PTMs 23 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.ephrin receptor signaling pathway
.regulation of cytokinesis
.regulation of G-protein coupled receptor protein signaling pathway
.axon guidance
.zinc ion binding
.GTPase activator activity
.aggresome
.membrane
.focal adhesion
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 53 23
2014-09-19protein level
3 41 23
2014-05-27protein level
3 41 23
2014-02-25protein level
3 41 23
2013-12-09protein level
3 32 23
2013-11-01protein level
3 30 23
2013-09-12protein level
3 30 24
2013-08-17protein level
3 30 24
2013-07-15protein level
3 12 23
2013-06-11protein level
3 12 23
2013-02-12protein level
3 4 42
2012-12-20protein level
3 4 42
2012-10-30protein level
3 7 42
2012-10-07protein level
3 7 21
2012-08-24protein level
3 3 21
2012-07-28protein level
3 3 21
2012-06-08protein level
3 4 21
2012-05-07protein level
3 4 21
2012-04-10protein level
3 4 21
2012-01-13protein level
3 7 21
2011-12-20protein level
3 7 21
2011-11-11protein level
3 7 20
2011-08-23protein level
3 7 20
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y2X7-1
1 32 3 84288.5664
NX_Q9Y2X7-2
2 5 0 19147.5562
NX_Q9Y2X7-3
2 32 3 85393.0911
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-466061,EBI-3904795 ADRBK1  
  .cardiac muscle contraction
.neurotrophin TRK receptor signaling pathway
.viral entry into host cell
  + 17 more...
.beta-adrenergic receptor kinase activity
.Edg-2 lysophosphatidic acid receptor binding
.alpha-2A adrenergic receptor binding
  + 3 more...
.primary cilium
.membrane
.plasma membrane
  + 2 more...
2 EBI-466061,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
3 EBI-466061,EBI-523590 CHD3  
  .centrosome organization
.DNA duplex unwinding
.chromatin modification
  + 6 more...
.poly(A) RNA binding
.zinc ion binding
.ATP binding
  + 3 more...
.intermediate filament cytoskeleton
.NuRD complex
.centrosome
  + 4 more...
4 EBI-466061,EBI-1307 PAK1  
  .negative regulation of cell proliferation involved in contact inhibition
.positive regulation of stress fiber assembly
.T cell receptor signaling pathway
  + 32 more...
.Rac GTPase binding
.ATP binding
.collagen binding
  + 2 more...
.protein complex
.ruffle membrane
.nuclear membrane
  + 12 more...
5 EBI-466061,EBI-717515 ARHGEF7  
  .positive regulation of lamellipodium morphogenesis
.positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
  + 14 more...
.protein kinase binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.protein complex
.neuronal cell body
.neuron projection
  + 5 more...
6 EBI-466061,EBI-473196 LRIF1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nuclear matrix
.actin cytoskeleton
.microtubule organizing center
.nucleus
7 EBI-466061,EBI-473181 BARD1  
  .protein K6-linked ubiquitination
.negative regulation of protein export from nucleus
.positive regulation of protein catabolic process
  + 9 more...
.protein heterodimerization activity
.protein homodimerization activity
.kinase binding
  + 4 more...
.BRCA1-A complex
.intracellular membrane-bounded organelle
.BRCA1-BARD1 complex
  + 5 more...
8 EBI-466061,EBI-473176 KIAA1377  
  .cilium assembly
.cytoplasmic microtubule organization
.mitotic spindle organization
.N/A .ciliary base
.midbody
.centrosome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites100
bladder33
blood65
bone111
bone marrow61
brain110
cervix41
connective tissue6
embryonic tissue46
esophagus49
eye90
heart67
intestine60
kidney28
liver34
lung110
lymph22
lymph node100
mammary gland85
mouth30
muscle197
nerve64
ovary118
pancreas84
parathyroid48
placenta21
prostate31
skin75
spleen56
stomach10
testis89
thymus112
thyroid42
tonsil58
trachea57
umbilical cord145
uterus34
vascular19
Health State
TissuesTPM*
normal69
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor57
chondrosarcoma96
colorectal tumor79
esophageal tumor57
gastrointestinal tumor59
germ cell tumor49
glioma139
head and neck tumor29
kidney tumor43
leukemia74
liver tumor72
lung tumor204
lymphoma13
non-neoplasia72
ovarian tumor144
pancreatic tumor47
primitive neuroectodermal tumor of the CNS125
prostate cancer38
retinoblastoma86
skin tumor103
soft tissue/muscle tissue tumor183
uterine tumor11
Developmental Stage
TissuesTPM*
adult69
embryoid body71
blastocyst32
neonate32
fetus70
infant85
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.7
adrenal gland11.4
appendix20.3
bone marrow8.7
cerebral cortex42.4
colon13.4
duodenum13.4
esophagus17.2
gallbladder16.7
heart muscle15.4
kidney12.2
liver4.5
lung23.8
lymph node21.3
ovary18.3
pancreas8.6
placenta19.8
prostate12.8
salivary gland14.3
skin28.7
small intestine14.9
spleen20.6
stomach13.6
testis78.9
thyroid gland19.3
urinary bladder17.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyLow
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608434, gene) G protein-coupled receptor kinase-interacting protein 1; GIT1OMIM


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