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> Protein (NX_Q9Y2X8)
Protein (NX_Q9Y2X8)
Protein
Gene SymbolUBE2D4 to neXtProt (NX_Q9Y2X8)
DescriptionUbiquitin-conjugating enzyme E2 D4
Chromosome7
Location7p13 (43966037 ~ 43995735) to Ensembl
Sequene Features : Isoforms 1, Variants 8, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein K6-linked ubiquitination
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 4 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 8 0
2014-09-19protein level
1 6 0
2014-05-27protein level
1 6 1
2014-02-25protein level
1 6 1
2013-12-09protein level
1 5 1
2013-11-01protein level
1 5 1
2013-09-12protein level
1 5 1
2013-08-17protein level
1 5 1
2013-07-15protein level
1 5 0
2013-06-11protein level
1 5 0
2013-02-12protein level
1 3 1
2012-12-20protein level
1 3 1
2012-10-30protein level
1 3 1
2012-10-07protein level
1 3 1
2012-08-24protein level
1 3 1
2012-07-28protein level
1 3 1
2012-06-08protein level
1 3 1
2012-05-07protein level
1 1 1
2012-04-10protein level
1 1 1
2012-01-13protein level
1 2 1
2011-12-20protein level
1 2 1
2011-11-11protein level
1 2 1
2011-08-23protein level
1 2 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y2X8-1
2 0 2 16638.3346
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-745527,EBI-6509505 INCA1  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of cell proliferation
.cyclin binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleus
2 EBI-745527,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
3 EBI-745527,EBI-740376 DTX2  
  .protein ubiquitination
.Notch signaling pathway
.ligase activity
.zinc ion binding
.nuclear membrane
.cytoplasm
.nucleoplasm
4 EBI-745527,EBI-2129250 ZNRF1  
  .protein K48-linked ubiquitination
.proteasome-mediated ubiquitin-dependent protein catabolic process
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.synaptic vesicle membrane
.cell junction
.membrane
  + 3 more...
5 EBI-745527,EBI-1058491 OTUB1  
  .negative regulation of double-strand break repair
.negative regulation of histone H2A K63-linked ubiquitination
.protein K48-linked deubiquitination
  + 3 more...
.ubiquitin binding
.ubiquitin protein ligase binding
.NEDD8-specific protease activity
.ubiquitin-specific protease activity
.extracellular exosome
.cytoplasm
6 EBI-745527,EBI-348482 RNF5  
  .regulation of autophagic vacuole assembly
.ER-associated misfolded protein catabolic process
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.endoplasmic reticulum membrane
7 EBI-745527,EBI-357322 RNF126  
  .cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
  + 7 more...
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.cytoplasm
.nucleus
8 EBI-745527,EBI-4307517 PHF7  
  .N/A .zinc ion binding .microtubule organizing center
.nucleoplasm
.nucleus
9 EBI-745527,EBI-2341005 MKRN2  
  .protein ubiquitination .poly(A) RNA binding
.ligase activity
.zinc ion binding
.intracellular
10 EBI-745527,EBI-739510 TRIM39  
  .positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
11 EBI-745527,EBI-2130308 RNF14  
  .regulation of androgen receptor signaling pathway
.positive regulation of transcription, DNA-templated
.response to estradiol
  + 6 more...
.androgen receptor binding
.ubiquitin-like protein transferase activity
.ligase activity
  + 2 more...
.cytoplasm
.nucleus
12 EBI-745527,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
13 EBI-745527,EBI-396669 RNF11  
  .protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.zinc ion binding
.ubiquitin-protein transferase activity
.DNA binding
.extracellular exosome
.recycling endosome
.early endosome
  + 2 more...
14 EBI-745527,EBI-2129242 RNF115  
  .protein K48-linked ubiquitination
.protein K63-linked ubiquitination
.protein autoubiquitination
  + 2 more...
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
blood32
brain21
cervix41
connective tissue13
embryonic tissue9
eye47
heart100
intestine34
kidney56
liver34
lung56
lymph node22
mammary gland33
muscle103
nerve64
ovary39
pancreas56
parathyroid48
placenta21
prostate52
skin71
spleen112
stomach10
testis20
thymus12
thyroid64
uterus21
Health State
TissuesTPM*
normal37
adrenal tumor79
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma12
colorectal tumor17
germ cell tumor22
glioma55
head and neck tumor7
kidney tumor14
liver tumor72
lung tumor58
lymphoma13
non-neoplasia72
ovarian tumor39
pancreatic tumor28
primitive neuroectodermal tumor of the CNS15
prostate cancer38
skin tumor87
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult41
blastocyst16
fetus53
infant85
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.6
adrenal gland18.8
appendix6.6
bone marrow2.6
cerebral cortex16
colon9.5
duodenum6.3
esophagus13.6
gallbladder12.2
heart muscle28.8
kidney15.9
liver9.2
lung9.3
lymph node6.7
ovary7.6
pancreas9.8
placenta8
prostate11.3
salivary gland14
skin7
small intestine7.4
spleen8.2
stomach7.4
testis6.9
thyroid gland16.4
urinary bladder15.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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