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> Protein (NX_Q9Y333)
Protein (NX_Q9Y333)
Protein
Gene SymbolLSM2 to neXtProt (NX_Q9Y333)
DescriptionU6 snRNA-associated Sm-like protein LSm2
Chromosome6
Location6p21.33 (31765173 ~ 31774761) to Ensembl
Sequene Features : Isoforms 1, Variants 7, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding
.Ral GTPase binding
.U6 snRNA binding
.catalytic step 2 spliceosome
.cytosol
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 7 1
2014-09-19protein level
1 5 1
2014-05-27protein level
1 5 1
2014-02-25protein level
1 0 1
2013-12-09protein level
1 0 1
2013-11-01protein level
1 0 1
2013-09-12protein level
1 0 1
2013-08-17protein level
1 0 1
2013-07-15protein level
1 0 1
2013-06-11protein level
1 0 1
2013-02-12protein level
1 0 2
2012-12-20protein level
1 0 2
2012-10-30protein level
1 0 2
2012-10-07protein level
1 0 2
2012-08-24protein level
1 0 2
2012-07-28protein level
1 0 2
2012-06-08protein level
1 0 2
2012-05-07protein level
1 0 2
2012-04-10protein level
1 0 2
2012-01-13protein level
1 0 2
2011-12-20protein level
1 0 2
2011-11-11protein level
1 0 2
2011-08-23protein level
1 0 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y333-1
5 0 0 10827.5953
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347416,EBI-347619 LSM1  
  .histone mRNA catabolic process
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
  + 5 more...
.poly(A) RNA binding
.RNA cap binding
.cytosol
.cytoplasm
.nucleus
.cytoplasmic mRNA processing body
2 EBI-347416,EBI-347779 LSM8  
  .mRNA splicing, via spliceosome .poly(A) RNA binding
.U6 snRNA 3'-end binding
.U6 snRNA binding
.U4/U6 x U5 tri-snRNP complex
.spliceosomal complex
3 EBI-347416,EBI-1045155 MAGEA6  
  .N/A .N/A .N/A
4 EBI-347416,EBI-724693 CLNS1A  
  .ncRNA metabolic process
.gene expression
.cell volume homeostasis
  + 2 more...
.protein heterodimerization activity
.poly(A) RNA binding
.pICln-Sm protein complex
.methylosome
.plasma membrane
  + 5 more...
5 EBI-347416,EBI-348239 LSM3  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.mRNA processing
  + 2 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.cytosol
.nucleus
6 EBI-347416,EBI-297993 SNRPD2  
  .ncRNA metabolic process
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.extracellular exosome
.SMN-Sm protein complex
  + 9 more...
7 EBI-347416,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
8 EBI-347416,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
9 EBI-347416,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
10 EBI-347416,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
11 EBI-347416,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
12 EBI-347416,EBI-347633 ZNF408  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.identical protein binding
.DNA binding
.nucleus
13 EBI-347416,EBI-348372 LSM7  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.mRNA splicing, via spliceosome
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.U6 snRNA binding .cytosol
.small nucleolar ribonucleoprotein complex
.spliceosomal complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bladder33
blood16
bone13
brain22
cervix20
connective tissue26
embryonic tissue46
eye76
heart89
intestine21
kidney14
liver38
lung23
lymph22
lymph node33
mammary gland26
mouth15
muscle18
ovary39
pancreas32
placenta31
prostate36
salivary gland49
skin23
stomach31
testis20
thymus12
thyroid21
tonsil293
uterus38
vascular38
Health State
TissuesTPM*
normal26
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma24
colorectal tumor26
gastrointestinal tumor25
germ cell tumor26
glioma46
kidney tumor14
leukemia10
liver tumor41
lung tumor38
lymphoma13
ovarian tumor52
pancreatic tumor28
primitive neuroectodermal tumor of the CNS15
prostate cancer38
retinoblastoma129
skin tumor39
soft tissue/muscle tissue tumor39
uterine tumor33
Developmental Stage
TissuesTPM*
adult20
embryoid body57
blastocyst32
fetus34
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.1
adrenal gland22.5
appendix28
bone marrow23.9
cerebral cortex17.6
colon31.1
duodenum19.9
esophagus19.7
gallbladder19.7
heart muscle16.6
kidney19.5
liver14.2
lung20.4
lymph node38.5
ovary24.9
pancreas9.8
placenta24.8
prostate17.5
salivary gland13.9
skin16.2
small intestine19.2
spleen26.3
stomach22.1
testis22.2
thyroid gland24.1
urinary bladder26
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607282, gene) Lsm2 protein; LSM2OMIM


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