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> Protein (NX_Q9Y371)
Protein (NX_Q9Y371)
Protein
Gene SymbolSH3GLB1 to neXtProt (NX_Q9Y371)
DescriptionEndophilin-B1
Chromosome1
Location1p22.3 (87170259 ~ 87213867) to Ensembl
Sequene Features : Isoforms 3, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of autophagic vacuole assembly
.positive regulation of protein targeting to mitochondrion
.protein localization to vacuolar membrane
  + 11 more...
.protein homodimerization activity
.identical protein binding
.lipid binding
.extracellular exosome
.midbody
.mitochondrial outer membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 34 2
2014-09-19protein level
3 28 2
2014-05-27protein level
3 28 2
2014-02-25protein level
3 28 2
2013-12-09protein level
3 21 2
2013-11-01protein level
3 20 2
2013-09-12protein level
3 20 1
2013-08-17protein level
3 20 1
2013-07-15protein level
3 11 1
2013-06-11protein level
3 11 1
2013-02-12protein level
3 3 3
2012-12-20protein level
2 3 2
2012-10-30protein level
2 5 2
2012-10-07protein level
2 5 1
2012-08-24protein level
2 5 1
2012-07-28protein level
2 5 1
2012-06-08protein level
2 8 1
2012-05-07protein level
2 6 1
2012-04-10protein level
2 6 1
2012-01-13protein level
2 6 1
2011-12-20protein level
2 6 1
2011-11-11protein level
2 6 1
2011-08-23protein level
2 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y371-1
0 15 1 40770.6583
NX_Q9Y371-2
2 14 1 43168.8466
NX_Q9Y371-3
1 9 0 29299.7612
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2623095,EBI-448167 GADD45A  
  .positive regulation of reactive oxygen species metabolic process
.positive regulation of p38MAPK cascade
.mitotic cell cycle arrest
  + 12 more...
.core promoter binding .cytoplasm
.nucleus
2 EBI-2623095,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
3 EBI-5291808,EBI-516580 BAX  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of apoptotic signaling pathway
  + 87 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.BAX complex
.Bcl-2 family protein complex
.extracellular exosome
  + 10 more...
4 EBI-2623095,EBI-3059266 FUNDC1  
  .response to hypoxia
.mitochondrion degradation
.N/A .integral component of mitochondrial outer membrane
.mitochondrial outer membrane
5 EBI-2623095,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
6 EBI-2623095,EBI-3921014 ZNF576  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
7 EBI-2623095,EBI-749607 SH3GLB2  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
8 EBI-2623095,EBI-2952704 UVRAG  
  .double-strand break repair via classical nonhomologous end joining
.regulation of protein serine/threonine kinase activity
.regulation of vesicle-mediated transport
  + 10 more...
.SNARE binding .phagocytic vesicle
.protein complex
.midbody
  + 6 more...
9 EBI-2623095,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland60
ascites50
blood24
bone125
bone marrow41
brain90
cervix103
connective tissue73
embryonic tissue61
esophagus99
eye28
heart122
intestine60
kidney104
liver48
lung113
lymph45
lymph node155
mammary gland79
mouth75
muscle141
nerve128
ovary29
pancreas84
pituitary gland60
placenta88
prostate47
skin66
spleen74
stomach62
testis163
thymus50
thyroid64
tonsil58
trachea173
uterus90
vascular116
Health State
TissuesTPM*
normal97
breast (mammary gland) tumor21
cervical tumor86
chondrosarcoma132
colorectal tumor35
esophageal tumor115
gastrointestinal tumor50
germ cell tumor110
glioma65
head and neck tumor37
kidney tumor145
leukemia10
liver tumor41
lung tumor87
lymphoma55
non-neoplasia144
ovarian tumor52
pancreatic tumor47
primitive neuroectodermal tumor of the CNS55
prostate cancer28
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor47
uterine tumor88
Developmental Stage
TissuesTPM*
adult78
embryoid body100
blastocyst32
fetus105
infant85
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue88
adrenal gland39.8
appendix59.7
bone marrow43.2
cerebral cortex27.1
colon58
duodenum47
esophagus84
gallbladder53.7
heart muscle60.2
kidney35.6
liver24.3
lung38.8
lymph node42.6
ovary23.5
pancreas33
placenta52.5
prostate36.5
salivary gland44.4
skin30.1
small intestine44.7
spleen43.8
stomach38.8
testis106.4
thyroid gland41.7
urinary bladder64.1
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
kidneyMedium
lateral ventricleLow
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleLow
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
soft tissue 1Medium
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609287, gene) Sh3 domain, grb2-like, endophilin b1; SH3GLB1OMIM


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