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> Protein (NX_Q9Y3B2)
Protein (NX_Q9Y3B2)
Protein
Gene SymbolEXOSC1 to neXtProt (NX_Q9Y3B2)
DescriptionExosome complex component CSL4
Chromosome10
Location10q24.1 (99195899 ~ 99205774) to Ensembl
Sequene Features : Isoforms 1, Variants 19, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.rRNA processing
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA binding .cytosol
.cytoplasm
.nucleolus
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 19 3
2014-09-19protein level
1 14 3
2014-05-27protein level
1 14 3
2014-02-25protein level
1 14 3
2013-12-09protein level
1 8 3
2013-11-01protein level
1 7 2
2013-09-12protein level
1 7 2
2013-08-17protein level
1 7 2
2013-07-15protein level
1 9 1
2013-06-11protein level
1 9 1
2013-02-12protein level
1 5 1
2012-12-20protein level
1 5 1
2012-10-30protein level
1 5 1
2012-10-07protein level
1 5 1
2012-08-24protein level
1 4 1
2012-07-28protein level
1 4 1
2012-06-08protein level
1 4 1
2012-05-07protein level
1 4 1
2012-04-10protein level
1 4 1
2012-01-13protein level
1 4 1
2011-12-20protein level
1 4 1
2011-11-11protein level
1 4 1
2011-08-23protein level
1 4 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y3B2-1
8 0 0 21437.9227
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-371892,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
2 EBI-371892,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
3 EBI-371892,EBI-371841 EXOSC7  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
  + 3 more...
.RNA binding
.3'-5'-exoribonuclease activity
.cytosol
.nucleolus
.nucleus
.exosome (RNase complex)
4 EBI-371892,EBI-9027502 KCTD1  
  .protein homooligomerization
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.transcription factor binding
.transcription corepressor activity
.nucleus
5 EBI-371892,EBI-371823 EXOSC4  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.polyadenylation-dependent snoRNA 3'-end processing
.histone mRNA catabolic process
  + 14 more...
.AU-rich element binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
6 EBI-371892,EBI-371876 EXOSC5  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.polyadenylation-dependent snoRNA 3'-end processing
.nuclear mRNA surveillance
  + 10 more...
.RNA binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
blood40
bone41
bone marrow61
brain21
connective tissue46
embryonic tissue51
esophagus49
eye14
heart89
intestine86
kidney23
liver38
lung41
lymph node66
mammary gland13
mouth30
muscle9
ovary9
pancreas28
parathyroid485
pharynx122
placenta38
prostate31
skin61
spleen56
stomach20
testis22
thymus75
thyroid42
trachea38
uterus56
Health State
TissuesTPM*
normal42
breast (mammary gland) tumor10
chondrosarcoma60
colorectal tumor71
esophageal tumor57
gastrointestinal tumor33
germ cell tumor22
glioma46
head and neck tumor22
kidney tumor14
leukemia42
liver tumor10
lung tumor38
lymphoma41
non-neoplasia31
pancreatic tumor19
prostate cancer48
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor55
Developmental Stage
TissuesTPM*
adult46
embryoid body28
fetus32
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.6
adrenal gland17.3
appendix22.2
bone marrow18.1
cerebral cortex12.6
colon22.5
duodenum20.3
esophagus21.1
gallbladder22.2
heart muscle16.7
kidney16.7
liver10.3
lung18.5
lymph node33.4
ovary20.8
pancreas18.1
placenta20.1
prostate17.6
salivary gland21.3
skin18.7
small intestine16.9
spleen20.6
stomach22
testis15.1
thyroid gland24.3
urinary bladder28.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606493, gene) Exosome component 1; EXOSC1OMIM


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