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> Protein (NX_Q9Y3B7)
Protein (NX_Q9Y3B7)
Protein
Gene SymbolMRPL11 to neXtProt (NX_Q9Y3B7)
Description39S ribosomal protein L11, mitochondrial
Chromosome11
Location11q13.2 (66202546 ~ 66234209) to Ensembl
Sequene Features : Isoforms 3, Variants 21, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 21 0
2014-09-19protein level
3 17 0
2014-05-27protein level
3 17 0
2014-02-25protein level
3 17 0
2013-12-09protein level
3 13 0
2013-11-01protein level
3 12 0
2013-09-12protein level
3 12 0
2013-08-17protein level
3 12 0
2013-07-15protein level
3 8 0
2013-06-11protein level
3 8 0
2013-02-12protein level
3 2 0
2012-12-20protein level
2 2 0
2012-10-30protein level
2 2 0
2012-10-07protein level
2 2 0
2012-08-24protein level
2 1 0
2012-07-28protein level
2 1 0
2012-06-08protein level
2 1 0
2012-05-07protein level
2 1 0
2012-04-10protein level
2 1 0
2012-01-13protein level
2 0 0
2011-12-20protein level
2 0 0
2011-11-11protein level
2 0 0
2011-08-23protein level
2 0 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y3B7-1
0 10 0 20670.3847
NX_Q9Y3B7-2
0 8 0 18193.9459
NX_Q9Y3B7-3
0 7 0 19441.7256
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-5453723,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-5453723,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
3 EBI-5453723,EBI-1058722 CAMK2B  
  .positive regulation of apoptotic signaling pathway
.regulation of cellular response to heat
.positive regulation of synapse maturation
  + 22 more...
.protein homodimerization activity
.ATP binding
.calmodulin-dependent protein kinase activity
.spindle midzone
.sarcoplasmic reticulum membrane
.endocytic vesicle membrane
  + 4 more...
4 EBI-5453723,EBI-351018 CAMK2D  
  .negative regulation of sodium ion transmembrane transporter activity
.regulation of generation of L-type calcium current
.negative regulation of sodium ion transmembrane transport
  + 41 more...
.ion channel binding
.protein homodimerization activity
.titin binding
  + 5 more...
.perinuclear region of cytoplasm
.axon initial segment
.neuronal cell body
  + 12 more...
5 EBI-5453723,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
6 EBI-5453723,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
7 EBI-5453723,EBI-10232636 SLC16A9  
  .urate metabolic process
.ion transmembrane transport
.monocarboxylic acid transport
.symporter activity
.monocarboxylic acid transmembrane transporter activity
.integral component of membrane
.plasma membrane
8 EBI-5453723,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
9 EBI-5453723,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
10 EBI-5453723,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
11 EBI-5453723,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
12 EBI-5453723,EBI-752007 JAKMIP2  
  .N/A .N/A .Golgi apparatus
13 EBI-5453723,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites100
bladder33
blood65
bone83
bone marrow20
brain35
cervix144
connective tissue13
embryonic tissue42
eye110
heart89
intestine51
kidney18
larynx42
liver63
lung62
lymph112
lymph node77
mammary gland46
muscle28
ovary29
pancreas79
parathyroid145
placenta60
prostate63
skin61
spleen18
stomach20
testis20
thyroid21
tonsil58
umbilical cord72
uterus47
Health State
TissuesTPM*
normal46
breast (mammary gland) tumor53
cervical tumor144
colorectal tumor35
gastrointestinal tumor59
germ cell tumor15
glioma205
head and neck tumor7
kidney tumor29
leukemia105
liver tumor83
lung tumor58
lymphoma69
ovarian tumor39
pancreatic tumor95
primitive neuroectodermal tumor of the CNS47
prostate cancer86
retinoblastoma107
skin tumor87
soft tissue/muscle tissue tumor63
uterine tumor33
Developmental Stage
TissuesTPM*
adult41
embryoid body71
neonate32
fetus102
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.5
adrenal gland14.1
appendix23.2
bone marrow26.6
cerebral cortex9.5
colon39
duodenum25.2
esophagus22
gallbladder16.7
heart muscle25.8
kidney23.1
liver21
lung18.3
lymph node28.3
ovary25.2
pancreas12.2
placenta19.5
prostate18.4
salivary gland22
skin14
small intestine26.3
spleen23
stomach22
testis15
thyroid gland17.5
urinary bladder21.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleLow
liverLow
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Low
skin 2Medium
small intestineHigh
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611826, gene) Mitochondrial ribosomal protein l11; MRPL11OMIM


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