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> Protein (NX_Q9Y3C5)
Protein (NX_Q9Y3C5)
Protein
Gene SymbolRNF11 to neXtProt (NX_Q9Y3C5)
DescriptionRING finger protein 11
Chromosome1
Location1p32.3 (51701943 ~ 51739127) to Ensembl
Sequene Features : Isoforms 1, Variants 11, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.zinc ion binding
.ubiquitin-protein transferase activity
.DNA binding
.extracellular exosome
.recycling endosome
.early endosome
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 11 4
2014-09-19protein level
1 10 4
2014-05-27protein level
1 10 4
2014-02-25protein level
1 10 3
2013-12-09protein level
1 9 3
2013-11-01protein level
1 8 3
2013-09-12protein level
1 8 3
2013-08-17protein level
1 8 3
2013-07-15protein level
1 4 3
2013-06-11protein level
1 4 3
2013-02-12protein level
1 2 2
2012-12-20protein level
1 2 2
2012-10-30protein level
1 2 2
2012-10-07protein level
1 2 2
2012-08-24protein level
1 2 2
2012-07-28protein level
1 2 2
2012-06-08protein level
1 12 2
2012-05-07protein level
1 12 2
2012-04-10protein level
1 12 2
2012-01-13protein level
1 12 2
2011-12-20protein level
1 12 2
2011-11-11protein level
1 12 2
2011-08-23protein level
1 12 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y3C5-1
7 0 0 17432.2293
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-396669,EBI-396676 STAMBP  
  .negative regulation of Ras protein signal transduction
.negative regulation of neuron apoptotic process
.protein deubiquitination
  + 4 more...
.metal ion binding
.protein domain specific binding
.metallopeptidase activity
.ubiquitin-specific protease activity
.extracellular exosome
.cleavage furrow
.plasma membrane
  + 4 more...
2 EBI-396669,EBI-413034 UBB  
  .positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
.regulation of neuron death
.programmed necrotic cell death
  + 96 more...
.N/A .extracellular exosome
.neuronal cell body
.neuron projection
  + 6 more...
3 EBI-396669,EBI-527670 TNFAIP3  
  .negative regulation of endothelial cell apoptotic process
.negative regulation of CD40 signaling pathway
.positive regulation of hepatocyte proliferation
  + 46 more...
.protein self-association
.ubiquitin binding
.ligase activity
  + 5 more...
.extracellular exosome
.cytosol
.centrosome
  + 3 more...
4 EBI-396669,EBI-726944 NEDD4  
  .negative regulation of sodium ion transmembrane transporter activity
.regulation of potassium ion transmembrane transporter activity
.protein K63-linked ubiquitination
  + 32 more...
.proline-rich region binding
.RNA polymerase binding
.ubiquitin protein ligase activity
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apicolateral plasma membrane
  + 8 more...
5 EBI-396669,EBI-743540 UBE2D1  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 22 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.protein complex
.cytosol
.cytoplasm
  + 2 more...
6 EBI-396669,EBI-348546 UBE2E1  
  .protein K48-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin conjugating enzyme activity
.ISG15 transferase activity
.ligase activity
  + 2 more...
.cytosol
.nucleoplasm
.nucleus
.ubiquitin ligase complex
7 EBI-396669,EBI-348268 UBE2D3  
  .positive regulation of protein targeting to mitochondrion
.cellular response to hypoxia
.protein K11-linked ubiquitination
  + 24 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.endosome membrane
.plasma membrane
  + 2 more...
8 EBI-396669,EBI-1052908 UBE2N  
  .protein K63-linked ubiquitination
.nucleotide-binding oligomerization domain containing signaling pathway
.positive regulation of ubiquitin-protein transferase activity
  + 29 more...
.ubiquitin protein ligase activity
.poly(A) RNA binding
.ubiquitin binding
  + 5 more...
.extracellular exosome
.protein complex
.UBC13-UEV1A complex
  + 5 more...
9 EBI-396669,EBI-347677 UBE2D2  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 12 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.protein complex
.cytosol
  + 2 more...
10 EBI-396669,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
11 EBI-396669,EBI-1564678 ITCH  
  .regulation of protein deubiquitination
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
  + 21 more...
.ubiquitin protein ligase activity
.CXCR chemokine receptor binding
.ribonucleoprotein complex binding
  + 2 more...
.extracellular exosome
.cytoplasmic vesicle
.membrane
  + 5 more...
12 EBI-396669,EBI-396727 SMURF2  
  .positive regulation of trophoblast cell migration
.positive regulation of canonical Wnt signaling pathway
.negative regulation of transcription, DNA-templated
  + 11 more...
.ubiquitin protein ligase activity
.SMAD binding
.identical protein binding
  + 2 more...
.membrane raft
.plasma membrane
.cytosol
  + 4 more...
13 EBI-396669,EBI-447141 GGA1  
  .positive regulation of protein catabolic process
.vesicle-mediated transport
.intracellular protein transport
.N/A .intracellular membrane-bounded organelle
.clathrin adaptor complex
.membrane
  + 3 more...
14 EBI-396669,EBI-745527 UBE2D4  
  .protein K6-linked ubiquitination
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 4 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland30
ascites25
bladder133
blood32
bone41
bone marrow82
brain130
cervix20
connective tissue26
ear310
embryonic tissue51
eye33
heart67
intestine34
kidney80
larynx42
liver58
lung59
lymph node22
mammary gland92
mouth75
muscle84
nerve193
ovary59
pancreas98
parathyroid388
pituitary gland60
placenta148
prostate79
salivary gland98
skin94
spleen93
stomach114
testis160
thymus37
thyroid107
trachea38
uterus86
vascular309
Health State
TissuesTPM*
normal86
adrenal tumor79
bladder carcinoma284
breast (mammary gland) tumor64
cervical tumor28
chondrosarcoma12
colorectal tumor17
gastrointestinal tumor42
germ cell tumor94
glioma83
head and neck tumor67
kidney tumor145
leukemia63
liver tumor93
lung tumor29
non-neoplasia62
ovarian tumor65
pancreatic tumor28
primitive neuroectodermal tumor of the CNS47
prostate cancer115
retinoblastoma43
skin tumor95
soft tissue/muscle tissue tumor71
uterine tumor66
Developmental Stage
TissuesTPM*
adult79
embryoid body42
blastocyst48
neonate64
fetus78
infant170
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue83
adrenal gland96.8
appendix41.3
bone marrow67
cerebral cortex123.8
colon53.6
duodenum46.7
esophagus118.3
gallbladder71.4
heart muscle84.9
kidney79.8
liver52.2
lung61.7
lymph node32.3
ovary125.8
pancreas25.6
placenta73.4
prostate68.5
salivary gland34.7
skin37.2
small intestine45.7
spleen44.1
stomach48.5
testis58.2
thyroid gland118.3
urinary bladder83.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612598, gene) Ring finger protein 11; RNF11OMIM


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