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> Protein (NX_Q9Y3D6)
Protein (NX_Q9Y3D6)
Protein
Gene SymbolFIS1 to neXtProt (NX_Q9Y3D6)
DescriptionMitochondrial fission 1 protein
Chromosome7
Location7q22.1 (100882739 ~ 100895597) to Ensembl
Sequene Features : Isoforms 1, Variants 17, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of protein targeting to membrane
.positive regulation of mitochondrial fission
  + 15 more...
.receptor binding .protein complex
.integral component of mitochondrial outer membrane
.membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 17 1
2014-09-19protein level
1 10 1
2014-05-27protein level
1 10 1
2014-02-25protein level
1 10 1
2013-12-09protein level
1 7 1
2013-11-01protein level
1 6 1
2013-09-12protein level
1 6 1
2013-08-17protein level
1 6 1
2013-07-15protein level
1 3 1
2013-06-11protein level
1 3 1
2013-02-12protein level
1 2 1
2012-12-20protein level
1 2 1
2012-10-30protein level
1 2 1
2012-10-07protein level
1 2 1
2012-08-24protein level
1 1 1
2012-07-28protein level
1 1 1
2012-06-08protein level
1 10 1
2012-05-07protein level
1 10 1
2012-04-10protein level
1 10 1
2012-01-13protein level
1 11 1
2011-12-20protein level
1 11 1
2011-11-11protein level
1 11 1
2011-08-23protein level
1 11 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y3D6-1
6 0 0 16926.9694
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3385283,EBI-77683 BCAP31  
  .positive regulation of intrinsic apoptotic signaling pathway
.protein localization to endoplasmic reticulum exit site
.positive regulation of mitochondrial calcium ion concentration
  + 11 more...
.N/A .integral component of lumenal side of endoplasmic reticulum membrane
.endoplasmic reticulum-Golgi intermediate compartment membrane
.Golgi cisterna membrane
  + 7 more...
2 EBI-3385283,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
3 EBI-3385283,EBI-740987 MIEF1  
  .positive regulation of protein targeting to membrane
.positive regulation of mitochondrial fission
.mitochondrial fission
.ADP binding
.identical protein binding
.GDP binding
.integral component of membrane
.mitochondrial outer membrane
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites25
blood40
bone marrow102
brain50
cervix61
connective tissue13
embryonic tissue70
eye47
heart78
intestine47
kidney14
liver29
lung44
lymph45
lymph node22
mammary gland125
mouth45
muscle84
ovary59
pancreas28
parathyroid485
pituitary gland121
placenta52
prostate84
skin109
spleen56
stomach10
testis25
thymus75
trachea38
umbilical cord145
uterus107
vascular77
Health State
TissuesTPM*
normal55
breast (mammary gland) tumor118
cervical tumor86
chondrosarcoma12
colorectal tumor44
gastrointestinal tumor25
germ cell tumor11
glioma83
head and neck tumor22
leukemia42
liver tumor52
lung tumor38
lymphoma41
ovarian tumor78
pancreatic tumor47
primitive neuroectodermal tumor of the CNS15
prostate cancer86
retinoblastoma43
skin tumor119
soft tissue/muscle tissue tumor15
uterine tumor44
Developmental Stage
TissuesTPM*
adult66
embryoid body142
blastocyst32
neonate64
fetus64
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue102.2
adrenal gland134
appendix68.1
bone marrow81.3
cerebral cortex99.7
colon88.4
duodenum86.1
esophagus114.4
gallbladder96
heart muscle207
kidney133.6
liver104.4
lung93.2
lymph node87
ovary120.8
pancreas85.9
placenta90.6
prostate94.8
salivary gland108.2
skin87.2
small intestine80.6
spleen89.8
stomach78.5
testis87.7
thyroid gland157.2
urinary bladder114.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungLow
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1High
stomach 2High
testisMedium
thyroid glandHigh
tonsilLow
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609003, gene) Tetratricopeptide repeat domain 11; TTC11OMIM


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