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> Protein (NX_Q9Y3I0)
Protein (NX_Q9Y3I0)
Protein
Gene SymbolRTCB to neXtProt (NX_Q9Y3I0)
DescriptiontRNA-splicing ligase RtcB homolog
Chromosome22
Location22q12.3 (32783569 ~ 32808242) to Ensembl
Sequene Features : Isoforms 1, Variants 14, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.tRNA splicing, via endonucleolytic cleavage and ligation
.placenta development
.in utero embryonic development
.metal ion binding
.poly(A) RNA binding
.vinculin binding
  + 2 more...
.tRNA-splicing ligase complex
.endoplasmic reticulum membrane
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 14 5
2014-09-19protein level
1 44 5
2014-05-27protein level
1 44 5
2014-02-25protein level
1 43 5
2013-12-09protein level
1 32 5
2013-11-01protein level
1 31 3
2013-09-12protein level
1 31 3
2013-08-17protein level
1 31 3
2013-07-15protein level
1 19 0
2013-06-11protein level
1 19 0
2013-02-12protein level
1 5 2
2012-12-20protein level
1 5 2
2012-10-30protein level
1 8 2
2012-10-07protein level
1 8 2
2012-08-24protein level
1 6 2
2012-07-28protein level
1 6 2
2012-06-08protein level
1 10 2
2012-05-07protein level
1 10 2
2012-04-10protein level
1 10 2
2012-01-13protein level
1 9 2
2011-12-20protein level
1 9 2
2011-11-11protein level
1 9 2
2011-08-23protein level
1 9 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y3I0-1
26 0 0 55174.6984
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2107208,EBI-741243 APPL1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland576
ascites225
bladder368
blood220
bone69
bone marrow41
brain204
cervix309
connective tissue254
embryonic tissue122
esophagus396
eye119
heart223
intestine250
kidney218
larynx213
liver194
lung179
lymph203
lymph node44
mammary gland185
mouth90
muscle423
ovary384
pancreas65
pharynx441
placenta219
prostate137
salivary gland592
skin275
spleen74
stomach156
testis144
thymus439
thyroid236
tonsil117
trachea154
umbilical cord217
uterus245
vascular367
Health State
TissuesTPM*
normal176
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor171
cervical tumor318
chondrosarcoma108
colorectal tumor222
esophageal tumor405
gastrointestinal tumor135
germ cell tumor284
glioma223
head and neck tumor194
kidney tumor203
leukemia137
liver tumor218
lung tumor291
lymphoma249
non-neoplasia300
ovarian tumor315
pancreatic tumor95
primitive neuroectodermal tumor of the CNS566
prostate cancer77
retinoblastoma107
skin tumor342
soft tissue/muscle tissue tumor399
uterine tumor233
Developmental Stage
TissuesTPM*
adult138
embryoid body114
blastocyst113
neonate289
fetus104
infant297
juvenile287
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue33.1
adrenal gland37.1
appendix39.5
bone marrow23.8
cerebral cortex31.6
colon59.3
duodenum81.9
esophagus45.7
gallbladder37.8
heart muscle34.5
kidney55.6
liver36.2
lung34.5
lymph node45.7
ovary44.9
pancreas21.5
placenta44
prostate41
salivary gland27.8
skin48.8
small intestine71.3
spleen36.6
stomach43.7
testis35.3
thyroid gland44.8
urinary bladder46.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*613901, gene) Chromosome 22 open reading frame 28; C22ORF28OMIM


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