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> Protein (NX_Q9Y3Y2)
Protein (NX_Q9Y3Y2)
Protein
Gene SymbolCHTOP to neXtProt (NX_Q9Y3Y2)
DescriptionChromatin target of PRMT1 protein
Chromosome1
Location1q21.3 (153606525 ~ 153618782) to Ensembl
Sequene Features : Isoforms 3, Variants 36, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of helicase activity
.positive regulation of ATPase activity
.mRNA export from nucleus
  + 2 more...
.poly(A) RNA binding .intracellular membrane-bounded organelle
.nuclear speck
.nucleolus
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 36 11
2014-09-19protein level
3 31 11
2014-05-27protein level
3 31 11
2014-02-25protein level
3 31 8
2013-12-09protein level
3 22 8
2013-11-01protein level
3 20 7
2013-09-12protein level
3 20 6
2013-08-17protein level
3 20 6
2013-07-15protein level
3 14 4
2013-06-11protein level
3 14 4
2013-02-12protein level
3 5 12
2012-12-20protein level
3 5 12
2012-10-30protein level
3 6 12
2012-10-07protein level
3 6 4
2012-08-24protein level
3 6 4
2012-07-28protein level
3 6 4
2012-06-08protein level
3 3 4
2012-05-07protein level
3 3 4
2012-04-10protein level
3 3 4
2012-01-13protein level
3 3 4
2011-12-20protein level
3 3 4
2011-11-11protein level
3 3 3
2011-08-23protein level
3 3 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y3Y2-1
0 8 0 26380.1972
NX_Q9Y3Y2-3
0 8 0 26508.2917
NX_Q9Y3Y2-4
0 8 0 21904.7354
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347794,EBI-711389 ERH  
  .positive regulation of Notch signaling pathway
.cell cycle
.pyrimidine nucleotide biosynthetic process
  + 3 more...
.poly(A) RNA binding .midbody
.membrane
2 EBI-347794,EBI-348622 DDX39B  
  .negative regulation of DNA damage checkpoint
.viral mRNA export from host cell nucleus
.positive regulation of DNA-templated transcription, elongation
  + 5 more...
.poly(A) RNA binding
.ATP-dependent protein binding
.U4 snRNA binding
  + 4 more...
.nuclear speck
.cytoplasm
.nucleolus
  + 4 more...
3 EBI-347794,EBI-395421 SMN2  
  .ncRNA metabolic process
.gene expression
.nervous system development
  + 2 more...
.identical protein binding
.RNA binding
.Gemini of coiled bodies
.SMN-Sm protein complex
.SMN complex
  + 7 more...
4 EBI-347794,EBI-742808 KHDRBS2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(U) RNA binding
.poly(A) binding
.nucleus
5 EBI-347794,EBI-347640 ALYREF  
  .viral mRNA export from host cell nucleus
.positive regulation of DNA-templated transcription, elongation
.replication fork processing
  + 9 more...
.poly(A) RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.extracellular exosome
.intracellular membrane-bounded organelle
  + 6 more...
6 EBI-347794,EBI-78738 PRMT1  
  .negative regulation of megakaryocyte differentiation
.histone H4-R3 methylation
.neuron projection development
  + 7 more...
.poly(A) RNA binding
.histone methyltransferase activity (H4-R3 specific)
.identical protein binding
  + 5 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
7 EBI-347794,EBI-398874 NXF1  
  .poly(A)+ mRNA export from nucleus
.viral process
.gene expression
.mRNA export from nucleus
.poly(A) RNA binding
.nucleocytoplasmic transporter activity
.mRNA binding
.nucleotide binding
.nuclear inclusion body
.nuclear speck
.cytosol
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland151
ascites150
blood122
bone167
bone marrow61
brain129
cervix144
connective tissue87
embryonic tissue70
esophagus49
eye81
heart122
intestine116
kidney156
larynx127
liver258
lung110
lymph45
lymph node100
mammary gland85
mouth256
muscle84
nerve64
ovary98
pancreas168
parathyroid145
pharynx24
pituitary gland60
placenta81
prostate84
salivary gland49
skin66
spleen262
stomach62
testis156
thymus100
thyroid85
tonsil117
trachea19
uterus107
vascular116
Health State
TissuesTPM*
normal110
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor85
cervical tumor173
chondrosarcoma108
colorectal tumor133
esophageal tumor57
gastrointestinal tumor75
germ cell tumor254
glioma177
head and neck tumor52
kidney tumor217
leukemia169
liver tumor510
lung tumor29
lymphoma41
non-neoplasia93
ovarian tumor105
pancreatic tumor314
primitive neuroectodermal tumor of the CNS102
prostate cancer48
retinoblastoma129
skin tumor39
soft tissue/muscle tissue tumor63
uterine tumor77
Developmental Stage
TissuesTPM*
adult111
embryoid body71
blastocyst65
neonate64
fetus75
infant170
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue27.1
adrenal gland37
appendix43.7
bone marrow54.8
cerebral cortex34.5
colon32
duodenum31
esophagus26.8
gallbladder28.9
heart muscle40.5
kidney30.8
liver17.5
lung36
lymph node53.5
ovary50.7
pancreas22.4
placenta39.2
prostate40.8
salivary gland27
skin36.2
small intestine33.5
spleen48.7
stomach36.7
testis37.9
thyroid gland41.2
urinary bladder34.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614206, gene) Chromatin target of prmt1; CHTOPOMIM


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