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> Protein (NX_Q9Y463)
Protein (NX_Q9Y463)
Protein
Gene SymbolDYRK1B to neXtProt (NX_Q9Y463)
DescriptionDual specificity tyrosine-phosphorylation-regulated kinase 1B
Chromosome19
Location19q13.2 (40315990 ~ 40324841) to Ensembl
Sequene Features : Isoforms 3, Variants 70, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.adipose tissue development
.positive regulation of transcription, DNA-templated
.myoblast fusion
.protein phosphorylation
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
  + 3 more...
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 70 2
2014-09-19protein level
3 54 2
2014-05-27protein level
3 54 3
2014-02-25protein level
3 54 3
2013-12-09protein level
3 45 3
2013-11-01protein level
3 43 3
2013-09-12protein level
3 43 3
2013-08-17protein level
3 43 3
2013-07-15protein level
3 28 2
2013-06-11protein level
3 28 2
2013-02-12protein level
3 15 9
2012-12-20protein level
3 15 9
2012-10-30protein level
3 15 9
2012-10-07protein level
3 15 3
2012-08-24protein level
3 8 3
2012-07-28protein level
3 8 3
2012-06-08protein level
3 11 3
2012-05-07protein level
3 11 3
2012-04-10protein level
3 11 3
2012-01-13protein level
3 11 3
2011-12-20protein level
3 11 3
2011-11-11protein level
3 11 4
2011-08-23protein level
3 11 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y463-1
2 21 6 69154.1849
NX_Q9Y463-2
0 20 6 64893.0696
NX_Q9Y463-3
1 21 6 66293.7452
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-634187,EBI-491274 RB1  
  .negative regulation of G1/S transition of mitotic cell cycle
.hepatocyte apoptotic process
.regulation of centromere complex assembly
  + 39 more...
.phosphoprotein binding
.androgen receptor binding
.identical protein binding
  + 7 more...
.Rb-E2F complex
.PML body
.SWI/SNF complex
  + 4 more...
2 EBI-634187,EBI-636034 HNF1A  
  .positive regulation of transcription initiation from RNA polymerase II promoter
.glucose import
.positive regulation of transcription from RNA polymerase II promoter
  + 5 more...
.protein dimerization activity
.protein heterodimerization activity
.transcription regulatory region DNA binding
  + 4 more...
.protein complex
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-634187,EBI-971402 RBL1  
  .regulation of cell cycle
.positive regulation of transcription from RNA polymerase II promoter
.regulation of lipid kinase activity
  + 8 more...
.transcription factor binding .transcription factor complex
.nucleoplasm
.nucleus
4 EBI-634187,EBI-602462 MAP2K3  
  .cardiac muscle contraction
.stress-activated MAPK cascade
.positive regulation of transcription, DNA-templated
  + 21 more...
.protein kinase binding
.ATP binding
.protein tyrosine kinase activity
  + 2 more...
.membrane
.cytosol
.cytoplasm
.nucleoplasm
5 EBI-634187,EBI-359808 DCAF7  
  .protein ubiquitination
.multicellular organismal development
.N/A .Cul4-RING E3 ubiquitin ligase complex
.protein complex
.nuclear matrix
  + 2 more...
6 EBI-634187,EBI-2349743 TROAP  
  .cell adhesion .N/A .cytoplasm
7 EBI-634187,EBI-636085 RANBP9  
  .negative regulation of ERK1 and ERK2 cascade
.axon guidance
.microtubule nucleation
.protein complex assembly
.enzyme binding
.Ran GTPase binding
.microtubule associated complex
.cytosol
.nucleus
8 EBI-634187,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
9 EBI-634187,EBI-634289 PCBD2  
  .protein heterooligomerization
.protein homotetramerization
.positive regulation of transcription, DNA-templated
.tetrahydrobiopterin biosynthetic process
.4-alpha-hydroxytetrahydrobiopterin dehydratase activity
.phenylalanine 4-monooxygenase activity
.mitochondrion
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood40
brain13
cervix103
connective tissue6
embryonic tissue32
eye33
heart11
intestine4
kidney23
lung8
lymph22
lymph node11
mammary gland6
nerve128
ovary39
pancreas98
prostate21
salivary gland98
skin4
spleen37
stomach20
testis140
thymus25
thyroid21
uterus25
Health State
TissuesTPM*
normal19
cervical tumor28
gastrointestinal tumor16
germ cell tumor7
glioma27
head and neck tumor22
kidney tumor14
leukemia31
lung tumor29
lymphoma27
non-neoplasia10
ovarian tumor13
pancreatic tumor142
primitive neuroectodermal tumor of the CNS165
prostate cancer38
retinoblastoma21
soft tissue/muscle tissue tumor7
uterine tumor44
Developmental Stage
TissuesTPM*
adult21
embryoid body14
blastocyst48
fetus16
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.3
adrenal gland9.7
appendix6.2
bone marrow5
cerebral cortex9.6
colon6.1
duodenum10.2
esophagus10.5
gallbladder7
heart muscle12.5
kidney11.7
liver3.3
lung9.9
lymph node8.3
ovary9.9
pancreas3.7
placenta5.1
prostate11.5
salivary gland7.1
skin8.5
small intestine7.1
spleen10.9
stomach7.4
testis44.1
thyroid gland10.7
urinary bladder9.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604556, gene) Dual-specificity tyrosine phosphorylation-regulated kinase 1b; DYRK1BOMIM


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