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> Protein (NX_Q9Y478)
Protein (NX_Q9Y478)
Protein
Gene SymbolPRKAB1 to neXtProt (NX_Q9Y478)
Description5'-AMP-activated protein kinase subunit beta-1
Chromosome12
Location12q24.23 (120105558 ~ 120119435) to Ensembl
Sequene Features : Isoforms 1, Variants 28, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane organization
.protein heterooligomerization
.regulation of protein kinase activity
  + 10 more...
.AMP-activated protein kinase activity
.protein kinase activity
.AMP-activated protein kinase complex
.cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 28 17
2014-09-19protein level
1 25 17
2014-05-27protein level
1 25 18
2014-02-25protein level
1 25 18
2013-12-09protein level
1 21 18
2013-11-01protein level
1 20 17
2013-09-12protein level
1 20 17
2013-08-17protein level
1 20 17
2013-07-15protein level
1 11 13
2013-06-11protein level
1 11 13
2013-02-12protein level
1 6 18
2012-12-20protein level
1 7 18
2012-10-30protein level
1 8 18
2012-10-07protein level
1 8 18
2012-08-24protein level
1 8 18
2012-07-28protein level
1 8 18
2012-06-08protein level
1 14 18
2012-05-07protein level
1 13 18
2012-04-10protein level
1 13 18
2012-01-13protein level
1 14 18
2011-12-20protein level
1 14 18
2011-11-11protein level
1 14 19
2011-08-23protein level
1 13 19
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y478-1
12 0 1 30363.186
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-719769,EBI-1181439 PRKAG1  
  .membrane organization
.protein heterooligomerization
.positive regulation of protein kinase activity
  + 12 more...
.ADP binding
.protein kinase binding
.AMP binding
  + 5 more...
.extracellular exosome
.AMP-activated protein kinase complex
.membrane
  + 2 more...
2 EBI-719769,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
3 EBI-719769,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites75
bladder66
blood81
bone27
bone marrow61
brain121
cervix123
connective tissue46
embryonic tissue28
esophagus49
eye110
heart100
intestine155
kidney99
larynx42
liver102
lung62
lymph22
lymph node77
mammary gland79
mouth90
muscle94
ovary59
pancreas126
parathyroid194
pituitary gland121
placenta28
prostate84
salivary gland49
skin18
spleen243
stomach52
testis91
thymus100
thyroid64
tonsil58
trachea115
uterus86
vascular77
Health State
TissuesTPM*
normal93
bladder carcinoma56
breast (mammary gland) tumor75
cervical tumor86
chondrosarcoma84
colorectal tumor71
esophageal tumor57
gastrointestinal tumor67
germ cell tumor75
glioma111
head and neck tumor59
kidney tumor29
leukemia63
liver tumor135
lung tumor77
lymphoma13
non-neoplasia41
ovarian tumor39
pancreatic tumor209
primitive neuroectodermal tumor of the CNS94
prostate cancer105
retinoblastoma107
skin tumor15
soft tissue/muscle tissue tumor95
uterine tumor122
Developmental Stage
TissuesTPM*
adult67
embryoid body14
blastocyst32
fetus154
infant127
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.7
adrenal gland17.2
appendix19
bone marrow28.9
cerebral cortex13.9
colon31.9
duodenum31.2
esophagus18.2
gallbladder16.3
heart muscle8.8
kidney48.9
liver10.4
lung26.6
lymph node20.4
ovary14.6
pancreas17.1
placenta22.7
prostate12.7
salivary gland14
skin10.8
small intestine24
spleen26.6
stomach26.8
testis23.2
thyroid gland22.6
urinary bladder18.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
hippocampusMedium
kidneyMedium
lateral ventricleLow
liverLow
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602740, gene) Protein kinase, amp-activated, noncatalytic, beta-1; PRKAB1OMIM


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