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> Protein (NX_Q9Y4C2)
Protein (NX_Q9Y4C2)
Protein
Gene SymbolFAM115A to neXtProt (NX_Q9Y4C2)
DescriptionProtein FAM115A
Chromosome7
Location7q35 (143548468 ~ 143599291) to Ensembl
Sequene Features : Isoforms 2, Variants 43, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of anion channel activity
.positive regulation of protein targeting to membrane
.negative regulation of cell migration
.transport
.ion channel binding .plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 43 9
2014-09-19protein level
2 25 9
2014-05-27protein level
2 25 9
2014-02-25protein level
2 25 9
2013-12-09protein level
2 22 9
2013-11-01protein level
2 20 3
2013-09-12protein level
2 20 3
2013-08-17protein level
2 20 3
2013-07-15protein level
2 12 0
2013-06-11protein level
2 12 0
2013-02-12protein level
2 7 0
2012-12-20protein level
2 7 0
2012-10-30protein level
2 6 0
2012-10-07protein level
2 6 0
2012-08-24protein level
2 5 0
2012-07-28protein level
2 5 0
2012-06-08protein level
2 6 0
2012-05-07protein level
2 6 0
2012-04-10protein level
2 6 0
2012-01-13protein level
2 4 0
2011-12-20protein level
2 4 0
2011-11-11protein level
2 4 0
2011-08-23protein level
2 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y4C2-1
1 39 0 102060.248
NX_Q9Y4C2-2
0 39 0 101826.137
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-750484,EBI-744493 ZNF263  
  .negative regulation of transcription, DNA-templated
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.microtubule cytoskeleton
.cytoplasm
.nucleoplasm
.nucleus
2 EBI-750484,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
3 EBI-750484,EBI-769630 TCF3  
  .regulation of G1/S transition of mitotic cell cycle
.positive regulation of muscle cell differentiation
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 21 more...
.E-box binding
.vitamin D response element binding
.repressing transcription factor binding
  + 12 more...
.RNA polymerase II transcription factor complex
.protein complex
.cytoplasm
  + 5 more...
4 EBI-750484,EBI-707773 ZNF24  
  .negative regulation of transcription, DNA-templated
.myelination
.transcription, DNA-templated
.sequence-specific DNA binding
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleoplasm
.nucleus
5 EBI-750484,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
6 EBI-750484,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
7 EBI-750484,EBI-1210420 ZNF592  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleoplasm
8 EBI-750484,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
9 EBI-750484,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites25
blood8
brain149
embryonic tissue32
kidney4
liver4
mammary gland6
placenta77
prostate10
salivary gland49
skin23
spleen18
testis68
thymus25
trachea115
uterus38
Health State
TissuesTPM*
normal58
adrenal tumor237
bladder carcinoma113
breast (mammary gland) tumor85
cervical tumor28
chondrosarcoma24
colorectal tumor35
gastrointestinal tumor118
germ cell tumor49
glioma27
head and neck tumor14
kidney tumor14
liver tumor10
primitive neuroectodermal tumor of the CNS7
skin tumor39
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult27
embryoid body85
blastocyst16
fetus71
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.6
adrenal gland45.4
appendix11.7
bone marrow2.3
cerebral cortex40.9
colon18.2
duodenum9.9
esophagus13.4
gallbladder19.6
heart muscle16.5
kidney14.3
liver14.5
lung16.7
lymph node7.3
ovary34.1
pancreas8.8
placenta57.4
prostate31.2
salivary gland10.5
skin13
small intestine13.2
spleen9.4
stomach16.2
testis9.7
thyroid gland25.5
urinary bladder16.8
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)


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