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> Protein (NX_Q9Y4D7)
Protein (NX_Q9Y4D7)
Protein
Gene SymbolPLXND1 to neXtProt (NX_Q9Y4D7)
DescriptionPlexin-D1
Chromosome3
Location3q22.1 (129274018 ~ 129325661) to Ensembl
Sequene Features : Isoforms 2, Variants 211, PTMs 27 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.semaphorin-plexin signaling pathway
.dichotomous subdivision of terminal units involved in salivary gland branching
.regulation of angiogenesis
  + 8 more...
.protein domain specific binding
.semaphorin receptor activity
.lamellipodium
.integral component of plasma membrane
.plasma membrane
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 211 27
2014-09-19protein level
2 173 27
2014-05-27protein level
2 173 27
2014-02-25protein level
2 171 27
2013-12-09protein level
2 120 27
2013-11-01protein level
2 113 27
2013-09-12protein level
2 113 27
2013-08-17protein level
2 113 27
2013-07-15protein level
2 87 27
2013-06-11protein level
2 87 27
2013-02-12protein level
2 54 54
2012-12-20protein level
2 50 54
2012-10-30protein level
2 61 54
2012-10-07protein level
2 61 27
2012-08-24protein level
2 46 27
2012-07-28protein level
2 46 27
2012-06-08protein level
2 47 27
2012-05-07protein level
2 45 27
2012-04-10protein level
2 45 27
2012-01-13protein level
2 17 18
2011-12-20protein level
2 17 18
2011-11-11protein level
2 17 18
2011-08-23protein level
2 17 18
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y4D7-1
6 80 0 211870.7766
NX_Q9Y4D7-2
1 80 0 195432.5782
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-310731,EBI-7283693 SEMA3E  
  .regulation of actin cytoskeleton reorganization
.semaphorin-plexin signaling pathway
.synapse organization
  + 6 more...
.receptor activity .membrane
.extracellular space
.extracellular region
2 EBI-310731,EBI-721550 NR4A1  
  .phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 13 more...
.sequence-specific DNA binding
.zinc ion binding
.ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 2 more...
.nuclear membrane
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-310731,EBI-3924922 SEMA4A  
  .semaphorin-plexin signaling pathway
.T-helper 1 cell differentiation
.negative regulation of angiogenesis
  + 4 more...
.receptor activity .integral component of membrane
.plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
bladder33
blood49
bone55
bone marrow143
brain37
connective tissue40
embryonic tissue42
eye52
heart134
intestine47
kidney61
larynx85
liver9
lung56
lymph22
lymph node22
mammary gland99
mouth30
muscle47
nerve321
ovary98
pancreas42
parathyroid48
pharynx24
placenta67
prostate26
skin94
spleen56
stomach52
testis25
thymus37
thyroid42
uterus51
vascular19
Health State
TissuesTPM*
normal36
bladder carcinoma56
breast (mammary gland) tumor85
chondrosarcoma48
colorectal tumor35
gastrointestinal tumor42
germ cell tumor68
glioma74
head and neck tumor37
kidney tumor101
leukemia63
liver tumor20
lung tumor38
lymphoma27
non-neoplasia72
ovarian tumor105
pancreatic tumor47
primitive neuroectodermal tumor of the CNS110
retinoblastoma86
skin tumor135
soft tissue/muscle tissue tumor95
uterine tumor55
Developmental Stage
TissuesTPM*
adult64
embryoid body57
blastocyst48
fetus50
infant127
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue109.8
adrenal gland43.7
appendix70.3
bone marrow44.3
cerebral cortex36.5
colon27
duodenum18.8
esophagus30.6
gallbladder75.4
heart muscle55.5
kidney30.5
liver18.1
lung125.5
lymph node69.2
ovary26.4
pancreas10.2
placenta137.6
prostate25.1
salivary gland18
skin34.4
small intestine21.1
spleen70.5
stomach24.4
testis27.4
thyroid gland46.9
urinary bladder72.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604282, gene) Plexin d1; PLXND1OMIM


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