Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q9Y4K3)
Protein (NX_Q9Y4K3)
Protein
Gene SymbolTRAF6 to neXtProt (NX_Q9Y4K3)
DescriptionTNF receptor-associated factor 6
Chromosome11
Location11p12 (36508577 ~ 36531822) to Ensembl
Sequene Features : Isoforms 1, Variants 69, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 69 6
2014-09-19protein level
1 56 6
2014-05-27protein level
1 56 6
2014-02-25protein level
1 54 6
2013-12-09protein level
1 45 6
2013-11-01protein level
1 43 6
2013-09-12protein level
1 43 6
2013-08-17protein level
1 43 6
2013-07-15protein level
1 30 6
2013-06-11protein level
1 30 6
2013-02-12protein level
1 13 4
2012-12-20protein level
1 12 4
2012-10-30protein level
1 13 4
2012-10-07protein level
1 13 4
2012-08-24protein level
1 6 4
2012-07-28protein level
1 6 4
2012-06-08protein level
1 19 4
2012-05-07protein level
1 19 4
2012-04-10protein level
1 19 4
2012-01-13protein level
1 21 4
2011-12-20protein level
1 21 4
2011-11-11protein level
1 21 4
2011-08-23protein level
1 21 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y4K3-1
24 0 0 59533.5363
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-359276,EBI-523498 TRAF5  
  .positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 4 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
  + 2 more...
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
2 EBI-359276,EBI-358684 MAP3K7  
  .negative regulation of apoptotic signaling pathway
.regulation of reactive oxygen species metabolic process
.negative regulation of ripoptosome assembly involved in necroptotic process
  + 37 more...
.scaffold protein binding
.ATP binding
.MAP kinase kinase kinase activity
  + 4 more...
.endosome membrane
.plasma membrane
.cytosol
  + 4 more...
3 EBI-359276,EBI-744798 TRAF3IP2  
  .immunoglobulin secretion
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.intracellular signal transduction
  + 3 more...
.N/A .N/A
4 EBI-359276,EBI-743272 USP2  
  .regulation of proteasomal protein catabolic process
.protein stabilization
.positive regulation of skeletal muscle tissue development
  + 11 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin binding
  + 2 more...
.perinuclear region of cytoplasm
.cell cortex
.centrosome
  + 2 more...
5 EBI-359276,EBI-515331 YES1  
  .cellular response to peptide hormone stimulus
.leukocyte migration
.ephrin receptor signaling pathway
  + 13 more...
.ion channel binding
.enzyme binding
.ATP binding
  + 3 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.focal adhesion
  + 6 more...
6 EBI-359276,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
7 EBI-359276,EBI-525905 IL1R1  
  .response to interleukin-1
.interleukin-1-mediated signaling pathway
.regulation of inflammatory response
  + 2 more...
.platelet-derived growth factor receptor binding
.interleukin-1, Type I, activating receptor activity
.interleukin-1 receptor activity
  + 2 more...
.membrane
.cell surface
.integral component of plasma membrane
  + 2 more...
8 EBI-359276,EBI-525714 CD40  
  .positive regulation of endothelial cell apoptotic process
.positive regulation of protein kinase C signaling
.cellular response to mechanical stimulus
  + 21 more...
.ubiquitin protein ligase binding
.enzyme binding
.receptor activity
  + 2 more...
.extracellular exosome
.intracellular membrane-bounded organelle
.CD40 receptor complex
  + 6 more...
9 EBI-359276,EBI-358664 IRAK1  
  .cellular response to hypoxia
.response to interleukin-1
.interleukin-1-mediated signaling pathway
  + 39 more...
.protein heterodimerization activity
.protein homodimerization activity
.kinase activity
  + 5 more...
.interleukin-1 receptor complex
.endosome membrane
.plasma membrane
  + 4 more...
10 EBI-359276,EBI-743540 UBE2D1  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 22 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.protein complex
.cytosol
.cytoplasm
  + 2 more...
11 EBI-359276,EBI-348268 UBE2D3  
  .positive regulation of protein targeting to mitochondrion
.cellular response to hypoxia
.protein K11-linked ubiquitination
  + 24 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.endosome membrane
.plasma membrane
  + 2 more...
12 EBI-359276,EBI-1052908 UBE2N  
  .protein K63-linked ubiquitination
.nucleotide-binding oligomerization domain containing signaling pathway
.positive regulation of ubiquitin-protein transferase activity
  + 29 more...
.ubiquitin protein ligase activity
.poly(A) RNA binding
.ubiquitin binding
  + 5 more...
.extracellular exosome
.protein complex
.UBC13-UEV1A complex
  + 5 more...
13 EBI-359276,EBI-347677 UBE2D2  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 12 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.protein complex
.cytosol
  + 2 more...
14 EBI-359276,EBI-517127 XIAP  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.positive regulation of protein linear polyubiquitination
.intrinsic apoptotic signaling pathway
  + 15 more...
.ubiquitin protein ligase activity
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
15 EBI-359276,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
16 EBI-359276,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
17 EBI-359276,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
18 EBI-359276,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
19 EBI-359276,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
20 EBI-359276,EBI-528190 ZNF675  
  .negative regulation of transcription regulatory region DNA binding
.negative regulation of interleukin-1-mediated signaling pathway
.negative regulation of JNK cascade
  + 9 more...
.ubiquitin protein ligase binding
.zinc ion binding
.DNA binding
.perinuclear region of cytoplasm
.nucleus
21 EBI-359276,EBI-2949647 EDARADD  
  .trachea gland development
.odontogenesis of dentin-containing tooth
.cell differentiation
  + 2 more...
.N/A .cytoplasm
22 EBI-359276,EBI-358011 MAP3K14  
  .cellular response to mechanical stimulus
.innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 9 more...
.ATP binding
.MAP kinase kinase kinase activity
.MAP kinase kinase activity
  + 3 more...
.cytosol
.cytoplasm
23 EBI-359276,EBI-6257338 RUSC1  
  .positive regulation of signal transduction
.protein polyubiquitination
.SH3/SH2 adaptor activity
.actin binding
.postsynaptic membrane
.cytoplasmic vesicle
.cell junction
  + 8 more...
24 EBI-359276,EBI-742388 PLEKHF2  
  .protein transport .metal ion binding .early endosome membrane
.transport vesicle
.endoplasmic reticulum
25 EBI-359276,EBI-985303 SPHK1  
  .cellular response to growth factor stimulus
.response to interleukin-1
.cellular response to hydrogen peroxide
  + 41 more...
.protein phosphatase 2A binding
.sphingosine-1-phosphate receptor activity
.D-erythro-sphingosine kinase activity
  + 7 more...
.axon
.synaptic vesicle
.plasma membrane
  + 3 more...
26 EBI-359276,EBI-1047372 MALT1  
  .protein oligomerization
.nuclear export
.positive regulation of NF-kappaB transcription factor activity
  + 20 more...
.protein self-association
.peptidase activity
.signal transducer activity
  + 2 more...
.perinuclear region of cytoplasm
.protein complex
.CBM complex
  + 5 more...
27 EBI-359276,EBI-741774 POLI  
  .error-prone translesion synthesis
.translesion synthesis
.DNA repair
.DNA replication
.metal ion binding
.DNA-directed DNA polymerase activity
.damaged DNA binding
.intracellular membrane-bounded organelle
.nucleoplasm
.nucleus
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites50
blood32
bone13
bone marrow20
brain7
cervix20
connective tissue6
ear62
embryonic tissue14
eye43
heart11
intestine21
kidney28
liver29
lung20
lymph22
lymph node22
mammary gland13
mouth45
muscle18
ovary9
parathyroid97
pharynx24
placenta31
prostate5
skin33
stomach31
testis11
thymus37
trachea19
uterus8
vascular19
Health State
TissuesTPM*
normal21
breast (mammary gland) tumor21
chondrosarcoma24
colorectal tumor35
gastrointestinal tumor42
germ cell tumor22
glioma27
head and neck tumor22
leukemia21
liver tumor31
lung tumor9
lymphoma27
ovarian tumor13
primitive neuroectodermal tumor of the CNS31
prostate cancer9
skin tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult22
embryoid body14
neonate32
fetus46
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.1
adrenal gland4.4
appendix5.6
bone marrow13.1
cerebral cortex4.6
colon5.2
duodenum5.1
esophagus6
gallbladder5.8
heart muscle5.5
kidney5.7
liver4.1
lung6
lymph node5.8
ovary7
pancreas3.3
placenta5.3
prostate3.9
salivary gland4.1
skin4.3
small intestine6.4
spleen7.1
stomach5.2
testis8
thyroid gland9.1
urinary bladder5.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602355, gene) Tnf receptor-associated factor 6; TRAF6OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center