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> Protein (NX_Q9Y4K4)
Protein (NX_Q9Y4K4)
Protein
Gene SymbolMAP4K5 to neXtProt (NX_Q9Y4K4)
DescriptionMitogen-activated protein kinase kinase kinase kinase 5
Chromosome14
Location14q21.3 (50885219 ~ 51027844) to Ensembl
Sequene Features : Isoforms 1, Variants 56, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of apoptotic process
.intracellular signal transduction
.regulation of mitotic cell cycle
  + 3 more...
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.plasma membrane
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 56 3
2014-09-19protein level
1 44 3
2014-05-27protein level
1 44 3
2014-02-25protein level
1 42 3
2013-12-09protein level
1 29 3
2013-11-01protein level
1 29 3
2013-09-12protein level
1 29 3
2013-08-17protein level
1 29 3
2013-07-15protein level
1 24 3
2013-06-11protein level
1 24 3
2013-02-12protein level
1 12 3
2012-12-20protein level
1 18 3
2012-10-30protein level
1 18 3
2012-10-07protein level
1 18 3
2012-08-24protein level
1 14 3
2012-07-28protein level
1 14 3
2012-06-08protein level
1 15 3
2012-05-07protein level
1 15 3
2012-04-10protein level
1 15 3
2012-01-13protein level
1 13 3
2011-12-20protein level
1 14 3
2011-11-11protein level
1 14 3
2011-08-23protein level
1 14 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y4K4-1
40 0 0 94979.0222
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1279,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-1279,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
3 EBI-1279,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood57
bone69
brain42
cervix20
connective tissue13
embryonic tissue42
eye19
intestine30
kidney23
larynx42
liver4
lung29
lymph node66
mammary gland39
mouth75
muscle28
ovary19
pancreas18
pituitary gland60
placenta35
prostate21
skin47
stomach62
testis25
thymus12
thyroid64
trachea77
umbilical cord145
uterus86
vascular38
Health State
TissuesTPM*
normal33
adrenal tumor79
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma36
colorectal tumor17
gastrointestinal tumor50
germ cell tumor26
glioma9
head and neck tumor59
leukemia74
non-neoplasia62
pancreatic tumor19
primitive neuroectodermal tumor of the CNS70
prostate cancer28
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor31
uterine tumor44
Developmental Stage
TissuesTPM*
adult35
embryoid body71
blastocyst16
neonate64
fetus26
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19
adrenal gland15.7
appendix15.4
bone marrow15.4
cerebral cortex23.7
colon16.4
duodenum15.2
esophagus23.8
gallbladder27.1
heart muscle8.9
kidney12.6
liver5.5
lung20.8
lymph node15.2
ovary35.5
pancreas6.3
placenta16.5
prostate20.6
salivary gland13.6
skin31.2
small intestine16.5
spleen18.9
stomach17.6
testis10.8
thyroid gland19.7
urinary bladder23.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604923, gene) Mitogen-activated protein kinase kinase kinase kinase 5; MAP4K5OMIM


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