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> Protein (NX_Q9Y4P1)
Protein (NX_Q9Y4P1)
Protein
Gene SymbolATG4B to neXtProt (NX_Q9Y4P1)
DescriptionCysteine protease ATG4B
Chromosome2
Location2q37.3 (242576628 ~ 242613272) to Ensembl
Sequene Features : Isoforms 5, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein delipidation
.positive regulation of protein catabolic process
.nucleophagy
  + 9 more...
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.endopeptidase activity
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 34 2
2014-09-19protein level
5 29 2
2014-05-27protein level
5 29 2
2014-02-25protein level
5 29 2
2013-12-09protein level
5 23 2
2013-11-01protein level
5 22 2
2013-09-12protein level
5 22 3
2013-08-17protein level
5 22 3
2013-07-15protein level
5 13 3
2013-06-11protein level
5 13 3
2013-02-12protein level
5 7 14
2012-12-20protein level
5 4 14
2012-10-30protein level
5 7 14
2012-10-07protein level
5 7 5
2012-08-24protein level
5 7 5
2012-07-28protein level
5 8 5
2012-06-08protein level
5 11 5
2012-05-07protein level
5 11 5
2012-04-10protein level
5 11 5
2012-01-13protein level
5 11 5
2011-12-20protein level
5 12 5
2011-11-11protein level
5 12 5
2011-08-23protein level
5 12 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y4P1-1
1 16 0 44265.5331
NX_Q9Y4P1-2
3 16 0 52495.2086
NX_Q9Y4P1-3
2 9 0 31021.3963
NX_Q9Y4P1-4
1 12 0 37013.0252
NX_Q9Y4P1-6
0 16 0 42593.8329
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-712014,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-712014,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
3 EBI-712014,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
4 EBI-712014,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites75
bladder66
blood171
bone83
bone marrow61
brain175
cervix206
connective tissue73
embryonic tissue136
esophagus148
eye71
heart67
intestine112
kidney90
liver92
lung98
lymph180
lymph node66
mammary gland72
mouth136
muscle122
nerve128
ovary197
pancreas37
placenta130
prostate73
salivary gland296
skin104
spleen18
stomach41
testis238
thymus112
thyroid21
uterus38
Health State
TissuesTPM*
normal103
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor64
cervical tumor173
chondrosarcoma169
colorectal tumor71
esophageal tumor173
gastrointestinal tumor59
germ cell tumor216
glioma149
head and neck tumor89
kidney tumor145
leukemia158
liver tumor52
lung tumor77
lymphoma138
non-neoplasia62
ovarian tumor236
pancreatic tumor28
primitive neuroectodermal tumor of the CNS291
prostate cancer48
retinoblastoma107
skin tumor127
soft tissue/muscle tissue tumor127
uterine tumor33
Developmental Stage
TissuesTPM*
adult96
embryoid body114
blastocyst113
neonate64
fetus140
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue30.1
adrenal gland34.1
appendix38.6
bone marrow45.5
cerebral cortex42.2
colon35.7
duodenum57.3
esophagus37.9
gallbladder46.8
heart muscle31.3
kidney33.9
liver20.9
lung40.1
lymph node47.7
ovary38.5
pancreas23.2
placenta35.1
prostate45.9
salivary gland27.2
skin44.5
small intestine53.7
spleen45.6
stomach38.5
testis62.5
thyroid gland38.9
urinary bladder39
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1Medium
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611338, gene) Autophagy 4, s. cerevisiae, homolog of, b; ATG4BOMIM


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