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> Protein (NX_Q9Y4W6)
Protein (NX_Q9Y4W6)
Protein
Gene SymbolAFG3L2 to neXtProt (NX_Q9Y4W6)
DescriptionAFG3-like protein 2
Chromosome18
Location18p11.21 (12328943 ~ 12377313) to Ensembl
Sequene Features : Isoforms 1, Variants 75, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.righting reflex
.muscle fiber development
.myelination
  + 8 more...
.unfolded protein binding
.zinc ion binding
.ATP binding
.metalloendopeptidase activity
.integral component of membrane
.mitochondrial inner membrane
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 75 8
2014-09-19protein level
1 58 8
2014-05-27protein level
1 58 8
2014-02-25protein level
1 58 7
2013-12-09protein level
1 49 7
2013-11-01protein level
1 49 1
2013-09-12protein level
1 49 3
2013-08-17protein level
1 49 3
2013-07-15protein level
1 36 3
2013-06-11protein level
1 36 3
2013-02-12protein level
1 17 4
2012-12-20protein level
1 17 4
2012-10-30protein level
1 19 4
2012-10-07protein level
1 19 4
2012-08-24protein level
1 18 4
2012-07-28protein level
1 18 4
2012-06-08protein level
1 20 4
2012-05-07protein level
1 20 4
2012-04-10protein level
1 19 4
2012-01-13protein level
1 17 4
2011-12-20protein level
1 17 4
2011-11-11protein level
1 17 4
2011-08-23protein level
1 17 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y4W6-1
36 0 1 88527.9282
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites50
bladder33
blood24
bone41
bone marrow41
brain28
cervix103
connective tissue26
embryonic tissue103
eye110
heart78
intestine90
kidney75
liver29
lung71
lymph180
lymph node33
mammary gland99
mouth15
muscle37
nerve128
ovary108
pancreas51
pharynx24
pituitary gland60
placenta52
prostate52
salivary gland148
skin199
stomach52
testis27
thyroid150
umbilical cord72
uterus86
vascular19
Health State
TissuesTPM*
normal39
breast (mammary gland) tumor75
cervical tumor28
chondrosarcoma60
colorectal tumor151
gastrointestinal tumor92
germ cell tumor45
glioma18
head and neck tumor67
kidney tumor87
leukemia31
liver tumor41
lung tumor126
lymphoma138
non-neoplasia31
ovarian tumor131
pancreatic tumor85
primitive neuroectodermal tumor of the CNS86
prostate cancer28
retinoblastoma236
skin tumor287
soft tissue/muscle tissue tumor71
uterine tumor110
Developmental Stage
TissuesTPM*
adult56
embryoid body114
blastocyst146
neonate32
fetus28
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.9
adrenal gland24.5
appendix23.1
bone marrow23.5
cerebral cortex25.2
colon47.8
duodenum68.4
esophagus36
gallbladder18.9
heart muscle67.6
kidney53
liver26.7
lung19
lymph node22.7
ovary21.3
pancreas19
placenta22.2
prostate22.2
salivary gland23.6
skin24.3
small intestine50.8
spleen18.8
stomach34.2
testis19.8
thyroid gland41.7
urinary bladder28.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateMedium
rectumHigh
salivary glandLow
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604581, gene) Atpase family gene 3-like 2; AFG3L2OMIM
2(#610246, phenotype) Spinocerebellar ataxia 28; SCA28OMIM
3(#614487, phenotype) Spastic ataxia 5, autosomal recessive; SPAX5OMIM


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