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> Protein (NX_Q9Y4Z0)
Protein (NX_Q9Y4Z0)
Protein
Gene SymbolLSM4 to neXtProt (NX_Q9Y4Z0)
DescriptionU6 snRNA-associated Sm-like protein LSm4
Chromosome19
Location19p13.11 (18417040 ~ 18434084) to Ensembl
Sequene Features : Isoforms 1, Variants 14, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.activation of mitophagy in response to mitochondrial depolarization
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
  + 4 more...
.poly(A) RNA binding .small nuclear ribonucleoprotein complex
.cytosol
.U6 snRNP
.spliceosomal complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 14 2
2014-09-19protein level
1 12 2
2014-05-27protein level
1 12 2
2014-02-25protein level
1 12 2
2013-12-09protein level
1 9 2
2013-11-01protein level
1 8 2
2013-09-12protein level
1 8 2
2013-08-17protein level
1 8 2
2013-07-15protein level
1 6 1
2013-06-11protein level
1 6 1
2013-02-12protein level
1 1 1
2012-12-20protein level
1 1 1
2012-10-30protein level
1 1 1
2012-10-07protein level
1 1 1
2012-08-24protein level
1 0 1
2012-07-28protein level
1 0 1
2012-06-08protein level
1 0 1
2012-05-07protein level
1 6 1
2012-04-10protein level
1 6 1
2012-01-13protein level
1 3 1
2011-12-20protein level
1 3 1
2011-11-11protein level
1 3 1
2011-08-23protein level
1 3 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y4Z0-1
5 0 0 15339.8498
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-372521,EBI-1050964 PSTPIP1  
  .innate immune response
.nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
.signal transduction
  + 3 more...
.N/A .perinuclear region of cytoplasm
.cleavage furrow
.lamellipodium
  + 5 more...
2 EBI-372521,EBI-347779 LSM8  
  .mRNA splicing, via spliceosome .poly(A) RNA binding
.U6 snRNA 3'-end binding
.U6 snRNA binding
.U4/U6 x U5 tri-snRNP complex
.spliceosomal complex
3 EBI-372521,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
4 EBI-372521,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
5 EBI-372521,EBI-10235384 ZBTB10  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleoplasm
6 EBI-372521,EBI-2686809 L3MBTL3  
  .erythrocyte maturation
.granulocyte differentiation
.macrophage differentiation
  + 3 more...
.N/A .nucleus
7 EBI-372521,EBI-348372 LSM7  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.mRNA splicing, via spliceosome
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.U6 snRNA binding .cytosol
.small nucleolar ribonucleoprotein complex
.spliceosomal complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites50
blood40
bone125
brain90
cervix82
connective tissue26
embryonic tissue70
eye129
heart234
intestine150
kidney61
liver58
lung241
lymph225
lymph node133
mammary gland125
muscle75
nerve64
ovary315
pancreas234
parathyroid631
placenta148
prostate73
salivary gland98
skin61
stomach114
testis167
thymus12
thyroid21
tonsil293
uterus43
vascular19
Health State
TissuesTPM*
normal98
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor85
cervical tumor86
chondrosarcoma120
colorectal tumor133
gastrointestinal tumor101
germ cell tumor56
glioma214
head and neck tumor22
kidney tumor72
leukemia127
liver tumor41
lung tumor214
lymphoma152
non-neoplasia62
ovarian tumor341
pancreatic tumor314
primitive neuroectodermal tumor of the CNS70
prostate cancer86
retinoblastoma64
skin tumor71
soft tissue/muscle tissue tumor95
uterine tumor22
Developmental Stage
TissuesTPM*
adult110
embryoid body71
blastocyst97
fetus156
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.4
adrenal gland49.7
appendix36.9
bone marrow41.4
cerebral cortex38.6
colon57.7
duodenum51
esophagus27.9
gallbladder22
heart muscle39.4
kidney55.8
liver26.7
lung32.3
lymph node42.5
ovary21.4
pancreas17
placenta37.8
prostate33.3
salivary gland26.1
skin26.7
small intestine50.1
spleen46.6
stomach51.9
testis61.5
thyroid gland31.9
urinary bladder30.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607284, gene) Lsm4 protein; LSM4OMIM


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