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> Protein (NX_Q9Y5K5)
Protein (NX_Q9Y5K5)
Protein
Gene SymbolUCHL5 to neXtProt (NX_Q9Y5K5)
DescriptionUbiquitin carboxyl-terminal hydrolase isozyme L5
Chromosome1
Location1q31.2 (192981380 ~ 193029237) to Ensembl
Sequene Features : Isoforms 4, Variants 34, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of proteasomal protein catabolic process
.forebrain morphogenesis
.midbrain development
  + 10 more...
.proteasome binding
.poly(A) RNA binding
.omega peptidase activity
  + 2 more...
.Ino80 complex
.cytosol
.nucleus
.proteasome complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 34 12
2014-09-19protein level
4 32 12
2014-05-27protein level
4 32 12
2014-02-25protein level
4 32 10
2013-12-09protein level
4 26 10
2013-11-01protein level
4 24 9
2013-09-12protein level
4 24 9
2013-08-17protein level
4 24 9
2013-07-15protein level
4 18 1
2013-06-11protein level
4 18 1
2013-02-12protein level
4 8 4
2012-12-20protein level
4 8 4
2012-10-30protein level
4 10 4
2012-10-07protein level
4 10 1
2012-08-24protein level
4 8 1
2012-07-28protein level
4 8 1
2012-06-08protein level
4 10 1
2012-05-07protein level
4 10 1
2012-04-10protein level
4 10 1
2012-01-13protein level
4 9 1
2011-12-20protein level
4 9 1
2011-11-11protein level
4 9 1
2011-08-23protein level
4 9 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y5K5-1
1 17 0 37582.8865
NX_Q9Y5K5-2
0 18 0 36056.0858
NX_Q9Y5K5-3
0 18 0 37453.8442
NX_Q9Y5K5-4
0 18 0 37328.7689
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1051183,EBI-740037 ZBED1  
  .metabolic process .metal ion binding
.transposase activity
.DNA binding
.nuclear chromosome
2 EBI-1051183,EBI-1245626 TFPT  
  .apoptotic signaling pathway
.positive regulation of apoptotic process
.regulation of transcription, DNA-templated
  + 3 more...
.DNA binding .nuclear membrane
.Ino80 complex
.actin filament
  + 4 more...
3 EBI-1051183,EBI-359318 PSMD4  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 21 more...
.poly(A) RNA binding
.identical protein binding
.proteasome accessory complex
.proteasome regulatory particle, base subcomplex
.cytosol
  + 3 more...
4 EBI-1051183,EBI-357793 PSMA6  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.proteolysis involved in cellular protein catabolic process
  + 26 more...
.NF-kappaB binding
.purine ribonucleoside triphosphate binding
.threonine-type endopeptidase activity
  + 2 more...
.extracellular exosome
.sarcomere
.myofibril
  + 10 more...
5 EBI-1051183,EBI-357648 PSMD2  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 21 more...
.enzyme regulator activity .extracellular exosome
.proteasome accessory complex
.membrane
  + 4 more...
6 EBI-1051183,EBI-954387 ADRM1  
  .proteasome assembly
.positive regulation of endopeptidase activity
.transcription elongation from RNA polymerase II promoter
.proteasome binding
.endopeptidase activator activity
.protease binding
.membrane
.integral component of plasma membrane
.plasma membrane
  + 3 more...
7 EBI-1051183,EBI-2511210 NFRKB  
  .inflammatory response
.transcription from RNA polymerase II promoter
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding
.protease binding
.Ino80 complex
.nucleoplasm
.nucleus
8 EBI-1051183,EBI-769401 INO80E  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA recombination
  + 2 more...
.N/A .Ino80 complex
.nucleolus
.nucleoplasm
.nucleus
9 EBI-1051183,EBI-769597 ACTR8  
  .cell division
.mitotic nuclear division
.regulation of transcription, DNA-templated
  + 4 more...
.ATP binding .Ino80 complex
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites75
bladder133
blood57
bone55
bone marrow102
brain65
cervix82
connective tissue67
embryonic tissue46
esophagus49
eye134
heart11
intestine38
kidney33
liver58
lung44
lymph45
lymph node77
mammary gland66
mouth60
muscle9
ovary19
pancreas37
pharynx24
placenta31
prostate31
salivary gland49
skin61
spleen18
stomach31
testis27
uterus47
vascular77
Health State
TissuesTPM*
normal48
bladder carcinoma113
breast (mammary gland) tumor53
cervical tumor115
chondrosarcoma24
colorectal tumor26
esophageal tumor57
gastrointestinal tumor50
germ cell tumor30
glioma9
head and neck tumor29
kidney tumor14
leukemia74
liver tumor62
lung tumor48
lymphoma27
non-neoplasia41
ovarian tumor65
pancreatic tumor38
primitive neuroectodermal tumor of the CNS47
prostate cancer9
retinoblastoma86
skin tumor87
soft tissue/muscle tissue tumor63
uterine tumor22
Developmental Stage
TissuesTPM*
adult45
embryoid body28
blastocyst32
neonate64
fetus25
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.7
adrenal gland17.1
appendix19.1
bone marrow12.3
cerebral cortex22
colon20.2
duodenum18.3
esophagus26.6
gallbladder13.5
heart muscle20.5
kidney21.4
liver17.7
lung12.5
lymph node23.7
ovary13.8
pancreas12.7
placenta16.1
prostate18.4
salivary gland15.9
skin15.4
small intestine19.6
spleen14.1
stomach15.2
testis12
thyroid gland16.1
urinary bladder18
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610667, gene) Ubiquitin carboxyl-terminal hydrolase l5; UCHL5OMIM


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