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> Protein (NX_Q9Y5K6)
Protein (NX_Q9Y5K6)
Protein
Gene SymbolCD2AP to neXtProt (NX_Q9Y5K6)
DescriptionCD2-associated protein
Chromosome6
Location6p12.3 (47445525 ~ 47594999) to Ensembl
Sequene Features : Isoforms 1, Variants 78, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of actin cytoskeleton reorganization
.positive regulation of protein localization to nucleus
.cell division
  + 5 more...
.SH3 domain binding
.structural constituent of cytoskeleton
.extracellular exosome
.filamentous actin
.actin cytoskeleton
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 78 15
2014-09-19protein level
1 57 15
2014-05-27protein level
1 57 15
2014-02-25protein level
1 57 15
2013-12-09protein level
1 48 15
2013-11-01protein level
1 45 15
2013-09-12protein level
1 45 15
2013-08-17protein level
1 45 15
2013-07-15protein level
1 37 15
2013-06-11protein level
1 37 15
2013-02-12protein level
1 21 7
2012-12-20protein level
1 22 7
2012-10-30protein level
1 25 7
2012-10-07protein level
1 25 7
2012-08-24protein level
1 24 7
2012-07-28protein level
1 24 7
2012-06-08protein level
1 24 7
2012-05-07protein level
1 19 7
2012-04-10protein level
1 19 7
2012-01-13protein level
1 3 7
2011-12-20protein level
1 3 7
2011-11-11protein level
1 3 4
2011-08-23protein level
1 3 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y5K6-1
33 0 0 71407.1205
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-298152,EBI-3912464 CD2  
  .positive regulation of interleukin-8 secretion
.positive regulation of interferon-gamma secretion
.leukocyte migration
  + 11 more...
.receptor binding
.receptor activity
.anchored component of plasma membrane
.cell surface
.cytoplasmic side of plasma membrane
  + 5 more...
2 EBI-298152,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
3 EBI-298152,EBI-297509 IQGAP1  
  .neuron projection extension
.glomerular visceral epithelial cell development
.positive regulation of protein serine/threonine kinase activity
  + 16 more...
.protein serine/threonine kinase activator activity
.protein phosphatase binding
.protein kinase binding
  + 5 more...
.extracellular exosome
.neuron projection
.cytoplasmic ribonucleoprotein granule
  + 15 more...
4 EBI-298152,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
5 EBI-298152,EBI-744027 CBLB  
  .negative regulation of T cell receptor signaling pathway
.negative regulation of alpha-beta T cell proliferation
.positive regulation of protein catabolic process
  + 7 more...
.ligase activity
.zinc ion binding
.calcium ion binding
  + 2 more...
.plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
6 EBI-298152,EBI-310624 PDCD6IP  
  .positive regulation of extracellular exosome assembly
.regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
  + 9 more...
.calcium-dependent protein binding
.protein homodimerization activity
.proteinase activated receptor binding
.endoplasmic reticulum exit site
.extracellular exosome
.melanosome
  + 7 more...
7 EBI-298152,EBI-2623522 BLNK  
  .intracellular signal transduction
.B cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity
.transmembrane receptor protein tyrosine kinase adaptor activity
.plasma membrane
.cytosol
.cytoplasm
.intracellular
8 EBI-298152,EBI-346882 TSG101  
  .positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder200
blood16
bone13
bone marrow41
brain9
cervix41
connective tissue53
embryonic tissue37
eye38
heart11
intestine86
kidney61
liver34
lung23
lymph node77
mammary gland72
muscle37
ovary68
pancreas42
placenta35
prostate42
salivary gland49
skin18
stomach31
testis22
thymus50
thyroid42
trachea57
uterus25
Health State
TissuesTPM*
normal29
adrenal tumor79
bladder carcinoma227
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma24
colorectal tumor44
gastrointestinal tumor42
germ cell tumor15
glioma9
head and neck tumor7
kidney tumor14
leukemia63
liver tumor31
lung tumor9
non-neoplasia62
ovarian tumor39
pancreatic tumor9
prostate cancer48
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor47
uterine tumor33
Developmental Stage
TissuesTPM*
adult36
embryoid body57
blastocyst48
fetus25
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12
adrenal gland11.4
appendix16.8
bone marrow10.9
cerebral cortex3.8
colon42
duodenum53.6
esophagus21.1
gallbladder18.2
heart muscle6.4
kidney33.3
liver11.3
lung18
lymph node16.5
ovary6.6
pancreas10.2
placenta20.8
prostate20.2
salivary gland12.8
skin16.7
small intestine55.9
spleen12.3
stomach38.8
testis11.2
thyroid gland19.1
urinary bladder37.2
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
bone marrowHigh
breastHigh
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
hippocampusLow
kidneyHigh
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineHigh
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604241, gene) Cd2-associated protein; CD2APOMIM
2(#607832, phenotype) Focal segmental glomerulosclerosis 3, susceptibility to; FSGS3OMIM


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