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	> Protein (NX_Q9Y5K6) Protein (NX_Q9Y5K6) Protein Gene Symbol CD2AP to neXtProt (NX_Q9Y5K6) Description CD2-associated protein Chromosome 6 Location 6p12.3 (47445525 ~ 47594999) to Ensembl Sequene Features : Isoforms 1, Variants 78, PTMs 15 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .regulation of actin cytoskeleton reorganization .positive regulation of protein localization to nucleus .cell division   + 5 more... .SH3 domain binding .structural constituent of cytoskeleton .extracellular exosome .filamentous actin .actin cytoskeleton   + 5 more... Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 1 78 15 2014-09-19 protein level 1 57 15 2014-05-27 protein level 1 57 15 2014-02-25 protein level 1 57 15 2013-12-09 protein level 1 48 15 2013-11-01 protein level 1 45 15 2013-09-12 protein level 1 45 15 2013-08-17 protein level 1 45 15 2013-07-15 protein level 1 37 15 2013-06-11 protein level 1 37 15 2013-02-12 protein level 1 21 7 2012-12-20 protein level 1 22 7 2012-10-30 protein level 1 25 7 2012-10-07 protein level 1 25 7 2012-08-24 protein level 1 24 7 2012-07-28 protein level 1 24 7 2012-06-08 protein level 1 24 7 2012-05-07 protein level 1 19 7 2012-04-10 protein level 1 19 7 2012-01-13 protein level 1 3 7 2011-12-20 protein level 1 3 7 2011-11-11 protein level 1 3 4 2011-08-23 protein level 1 3 4 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_Q9Y5K6-1 33 0 0 71407.1205 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-298152,EBI-3912464 CD2     .positive regulation of interleukin-8 secretion .positive regulation of interferon-gamma secretion .leukocyte migration   + 11 more... .receptor binding .receptor activity .anchored component of plasma membrane .cell surface .cytoplasmic side of plasma membrane   + 5 more... 2 EBI-298152,EBI-518228 CBL     .positive regulation of receptor-mediated endocytosis .negative regulation of apoptotic process .negative regulation of epidermal growth factor receptor signaling pathway   + 7 more... .ubiquitin protein ligase activity .ephrin receptor binding .SH3 domain binding   + 6 more... .flotillin complex .plasma membrane .cytosol   + 2 more... 3 EBI-298152,EBI-297509 IQGAP1     .neuron projection extension .glomerular visceral epithelial cell development .positive regulation of protein serine/threonine kinase activity   + 16 more... .protein serine/threonine kinase activator activity .protein phosphatase binding .protein kinase binding   + 5 more... .extracellular exosome .neuron projection .cytoplasmic ribonucleoprotein granule   + 15 more... 4 EBI-298152,EBI-401755 GRB2     .positive regulation of reactive oxygen species metabolic process .cellular response to ionizing radiation .branching involved in labyrinthine layer morphogenesis   + 25 more... .ephrin receptor binding .poly(A) RNA binding .insulin receptor substrate binding   + 6 more... .Grb2-EGFR complex .extracellular exosome .vesicle membrane   + 10 more... 5 EBI-298152,EBI-744027 CBLB     .negative regulation of T cell receptor signaling pathway .negative regulation of alpha-beta T cell proliferation .positive regulation of protein catabolic process   + 7 more... .ligase activity .zinc ion binding .calcium ion binding   + 2 more... .plasma membrane .cytosol .cytoplasm .nucleoplasm 6 EBI-298152,EBI-310624 PDCD6IP     .positive regulation of extracellular exosome assembly .regulation of extracellular exosome assembly .positive regulation of exosomal secretion   + 9 more... .calcium-dependent protein binding .protein homodimerization activity .proteinase activated receptor binding .endoplasmic reticulum exit site .extracellular exosome .melanosome   + 7 more... 7 EBI-298152,EBI-2623522 BLNK     .intracellular signal transduction .B cell differentiation .positive regulation of signal transduction   + 3 more... .SH3/SH2 adaptor activity .transmembrane receptor protein tyrosine kinase adaptor activity .plasma membrane .cytosol .cytoplasm .intracellular 8 EBI-298152,EBI-346882 TSG101     .positive regulation of viral budding via host ESCRT complex .regulation of viral budding via host ESCRT complex .regulation of extracellular exosome assembly   + 21 more... .calcium-dependent protein binding .virion binding .ubiquitin binding   + 4 more... .extracellular exosome .late endosome membrane .endosome membrane   + 8 more... EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* adrenal gland 30 ascites 50 bladder 200 blood 16 bone 13 bone marrow 41 brain 9 cervix 41 connective tissue 53 embryonic tissue 37 eye 38 heart 11 intestine 86 kidney 61 liver 34 lung 23 lymph node 77 mammary gland 72 muscle 37 ovary 68 pancreas 42 placenta 35 prostate 42 salivary gland 49 skin 18 stomach 31 testis 22 thymus 50 thyroid 42 trachea 57 uterus 25 Health State Tissues TPM* normal 29 adrenal tumor 79 bladder carcinoma 227 breast (mammary gland) tumor 42 cervical tumor 57 chondrosarcoma 24 colorectal tumor 44 gastrointestinal tumor 42 germ cell tumor 15 glioma 9 head and neck tumor 7 kidney tumor 14 leukemia 63 liver tumor 31 lung tumor 9 non-neoplasia 62 ovarian tumor 39 pancreatic tumor 9 prostate cancer 48 retinoblastoma 21 skin tumor 31 soft tissue/muscle tissue tumor 47 uterine tumor 33 Developmental Stage Tissues TPM* adult 36 embryoid body 57 blastocyst 48 fetus 25 juvenile 35 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 12 adrenal gland 11.4 appendix 16.8 bone marrow 10.9 cerebral cortex 3.8 colon 42 duodenum 53.6 esophagus 21.1 gallbladder 18.2 heart muscle 6.4 kidney 33.3 liver 11.3 lung 18 lymph node 16.5 ovary 6.6 pancreas 10.2 placenta 20.8 prostate 20.2 salivary gland 12.8 skin 16.7 small intestine 55.9 spleen 12.3 stomach 38.8 testis 11.2 thyroid gland 19.1 urinary bladder 37.2 Tissues Tissues Expression level adrenal gland Low appendix High bone marrow High breast High bronchus Medium cerebellum Low cerebral cortex Medium cervix, uterine High colon High duodenum High endometrium 1 High endometrium 2 High epididymis Medium esophagus Medium fallopian tube High gallbladder High hippocampus Low kidney High lateral ventricle Low liver Medium lung Medium lymph node Medium nasopharynx Medium oral mucosa Medium pancreas High parathyroid gland Medium placenta High prostate High rectum High salivary gland Medium seminal vesicle Medium skin 1 Medium skin 2 Medium small intestine High soft tissue 2 Medium spleen Medium stomach 1 High stomach 2 High testis Medium thyroid gland Medium tonsil Medium urinary bladder High vagina Medium Cancer Tumor Number of patients and Staining levels breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Expression level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Staining level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Not Detected Disease No. Disease Description Ref. 1 (*604241, gene) Cd2-associated protein; CD2AP OMIM 2 (#607832, phenotype) Focal segmental glomerulosclerosis 3, susceptibility to; FSGS3 OMIM

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