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> Protein (NX_Q9Y5R4)
Protein (NX_Q9Y5R4)
Protein
Gene SymbolHEMK1 to neXtProt (NX_Q9Y5R4)
DescriptionHemK methyltransferase family member 1
Chromosome3
Location3p21.2 (50606583 ~ 50622366) to Ensembl
Sequene Features : Isoforms 1, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.DNA methylation .protein methyltransferase activity
.N-methyltransferase activity
.DNA binding
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 33 0
2014-09-19protein level
1 24 0
2014-05-27protein level
1 24 0
2014-02-25protein level
1 23 0
2013-12-09protein level
1 17 0
2013-11-01protein level
1 16 0
2013-09-12protein level
1 16 0
2013-08-17protein level
1 16 0
2013-07-15protein level
1 12 0
2013-06-11protein level
1 12 0
2013-02-12protein level
1 9 0
2012-12-20protein level
1 7 0
2012-10-30protein level
1 15 0
2012-10-07protein level
1 15 0
2012-08-24transcript level
1 15 0
2012-07-28transcript level
1 15 0
2012-06-08transcript level
1 15 0
2012-05-07transcript level
1 14 0
2012-04-10transcript level
1 14 0
2012-01-13transcript level
1 7 0
2011-12-20transcript level
1 7 0
2011-11-11transcript level
1 7 0
2011-08-23transcript level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y5R4-1
13 0 0 38206.7163
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10329202,EBI-718947 CHN1  
  .regulation of small GTPase mediated signal transduction
.regulation of axonogenesis
.ephrin receptor signaling pathway
  + 3 more...
.metal ion binding
.GTPase activator activity
.SH3/SH2 adaptor activity
.cytosol
2 EBI-10329202,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood32
bone55
brain19
cervix61
connective tissue33
embryonic tissue23
eye9
heart11
intestine30
kidney80
larynx42
liver34
lung23
lymph22
lymph node133
mammary gland13
muscle28
ovary49
pancreas18
placenta17
prostate5
salivary gland98
skin9
testis48
thymus50
thyroid64
uterus30
Health State
TissuesTPM*
normal1
adrenal tumor79
breast (mammary gland) tumor10
chondrosarcoma60
colorectal tumor26
germ cell tumor3
glioma27
head and neck tumor29
kidney tumor87
leukemia42
liver tumor72
lung tumor38
lymphoma13
non-neoplasia41
ovarian tumor65
pancreatic tumor28
primitive neuroectodermal tumor of the CNS47
prostate cancer19
uterine tumor44
Developmental Stage
TissuesTPM*
adult7
embryoid body42
blastocyst16
fetus3
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.9
adrenal gland11.7
appendix12.2
bone marrow5.9
cerebral cortex5.9
colon12
duodenum11.8
esophagus10.2
gallbladder10.2
heart muscle9.8
kidney12.9
liver7.8
lung12.2
lymph node14.3
ovary19.1
pancreas11.3
placenta11.4
prostate16.2
salivary gland17.3
skin7.7
small intestine11.1
spleen14
stomach13.5
testis16.4
thyroid gland18.7
urinary bladder11.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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