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> Protein (NX_Q9Y5U2)
Protein (NX_Q9Y5U2)
Protein
Gene SymbolTSSC4 to neXtProt (NX_Q9Y5U2)
DescriptionProtein TSSC4
Chromosome11
Location11p15.5 (2421718 ~ 2425106) to Ensembl
Sequene Features : Isoforms 2, Variants 44, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 44 4
2014-09-19protein level
2 41 4
2014-05-27protein level
2 41 4
2014-02-25protein level
2 41 4
2013-12-09protein level
2 28 4
2013-11-01protein level
2 27 4
2013-09-12protein level
2 27 4
2013-08-17protein level
2 27 4
2013-07-15protein level
2 23 4
2013-06-11protein level
2 23 4
2013-02-12protein level
2 16 12
2012-12-20protein level
2 15 12
2012-10-30protein level
2 17 12
2012-10-07protein level
2 17 6
2012-08-24protein level
2 17 6
2012-07-28protein level
2 17 6
2012-06-08protein level
2 18 6
2012-05-07protein level
2 17 6
2012-04-10protein level
2 17 6
2012-01-13protein level
2 12 6
2011-12-20protein level
2 12 6
2011-11-11protein level
2 12 6
2011-08-23protein level
2 12 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y5U2-1
1 11 0 34304.53
NX_Q9Y5U2-2
1 11 0 27917.7487
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-717229,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
2 EBI-717229,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
3 EBI-717229,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
4 EBI-717229,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
5 EBI-717229,EBI-742887 CEP76  
  .regulation of centriole replication
.organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .protein complex
.cytosol
.centriole
.centrosome
6 EBI-717229,EBI-10225152 RNF31  
  .positive regulation of protein targeting to mitochondrion
.protein linear polyubiquitination
.positive regulation of NF-kappaB transcription factor activity
  + 4 more...
.ubiquitin binding
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.LUBAC complex
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
blood57
brain15
embryonic tissue18
eye38
heart11
intestine4
kidney9
liver4
lung20
lymph112
mammary gland13
ovary29
pancreas9
parathyroid48
placenta3
prostate5
salivary gland246
skin80
stomach52
testis11
thyroid21
uterus12
Health State
TissuesTPM*
normal15
breast (mammary gland) tumor21
gastrointestinal tumor16
germ cell tumor3
glioma27
head and neck tumor44
kidney tumor14
leukemia10
liver tumor10
lung tumor68
lymphoma83
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS31
prostate cancer9
skin tumor127
soft tissue/muscle tissue tumor23
Developmental Stage
TissuesTPM*
adult22
embryoid body14
blastocyst48
fetus8
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.4
adrenal gland9.6
appendix14.1
bone marrow22.7
cerebral cortex12.1
colon12
duodenum14
esophagus14.4
gallbladder12.8
heart muscle11.8
kidney13.1
liver7.4
lung13.8
lymph node16.4
ovary10.6
pancreas9.8
placenta12.2
prostate15.5
salivary gland13.6
skin12.8
small intestine12.4
spleen21.5
stomach13.3
testis40
thyroid gland11.7
urinary bladder13.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603852, gene) Tumor-suppressing subchromosomal transferable fragment candidate geneOMIM


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