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> Protein (NX_Q9Y5U4)
Protein (NX_Q9Y5U4)
Protein
Gene SymbolINSIG2 to neXtProt (NX_Q9Y5U4)
DescriptionInsulin-induced gene 2 protein
Chromosome2
Location2q14.2 (118846028 ~ 118868573) to Ensembl
Sequene Features : Isoforms 1, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to fatty acid
.cranial suture morphogenesis
.palate development
  + 9 more...
.N/A .SREBP-SCAP-Insig complex
.endoplasmic reticulum membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 33 1
2014-09-19protein level
1 25 1
2014-05-27protein level
1 25 1
2014-02-25protein level
1 25 1
2013-12-09protein level
1 21 1
2013-11-01protein level
1 21 1
2013-09-12protein level
1 21 1
2013-08-17protein level
1 21 1
2013-07-15protein level
1 12 0
2013-06-11protein level
1 12 0
2013-02-12protein level
1 4 0
2012-12-20protein level
1 4 0
2012-10-30protein level
1 5 0
2012-10-07protein level
1 5 0
2012-08-24protein level
1 5 0
2012-07-28protein level
1 5 0
2012-06-08protein level
1 6 0
2012-05-07protein level
1 3 0
2012-04-10protein level
1 3 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y5U4-1
9 0 0 24761.6606
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8503746,EBI-348482 RNF5  
  .regulation of autophagic vacuole assembly
.ER-associated misfolded protein catabolic process
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.endoplasmic reticulum membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
blood8
bone97
brain38
connective tissue53
embryonic tissue42
eye19
intestine8
kidney52
liver24
lung41
lymph node44
mammary gland13
muscle28
nerve193
pancreas42
parathyroid242
pharynx49
pituitary gland60
placenta56
prostate10
skin4
stomach20
testis36
thymus87
trachea57
uterus21
vascular58
Health State
TissuesTPM*
normal41
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma120
colorectal tumor8
gastrointestinal tumor25
germ cell tumor22
glioma18
head and neck tumor14
kidney tumor14
liver tumor20
lung tumor9
lymphoma27
non-neoplasia10
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer9
soft tissue/muscle tissue tumor23
Developmental Stage
TissuesTPM*
adult39
embryoid body42
blastocyst16
fetus57
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.7
adrenal gland11.2
appendix12.6
bone marrow4.6
cerebral cortex15.4
colon12.3
duodenum16.7
esophagus9.9
gallbladder14.4
heart muscle11.8
kidney17.7
liver25.4
lung18.6
lymph node15.4
ovary15.4
pancreas8.3
placenta15.3
prostate15.7
salivary gland9.2
skin12.3
small intestine16.8
spleen17.9
stomach16.4
testis11.2
thyroid gland16.7
urinary bladder14.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608660, gene) Insulin-induced gene 2; INSIG2OMIM


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