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> Protein (NX_Q9Y5V3)
Protein (NX_Q9Y5V3)
Protein
Gene SymbolMAGED1 to neXtProt (NX_Q9Y5V3)
DescriptionMelanoma-associated antigen D1
ChromosomeX
LocationXp11.22 (51546103 ~ 51645453) to Ensembl
Sequene Features : Isoforms 2, Variants 106, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
  + 15 more...
.transcription coactivator activity .protein complex
.plasma membrane
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 106 17
2014-09-19protein level
2 73 17
2014-05-27protein level
2 73 18
2014-02-25protein level
2 73 18
2013-12-09protein level
2 65 19
2013-11-01protein level
2 61 15
2013-09-12protein level
2 61 15
2013-08-17protein level
2 61 14
2013-07-15protein level
2 37 6
2013-06-11protein level
2 37 6
2013-02-12protein level
2 11 12
2012-12-20protein level
2 11 12
2012-10-30protein level
2 12 12
2012-10-07protein level
2 12 6
2012-08-24protein level
2 12 6
2012-07-28protein level
2 12 6
2012-06-08protein level
2 10 6
2012-05-07protein level
2 10 6
2012-04-10protein level
2 10 6
2012-01-13protein level
2 5 6
2011-12-20protein level
2 5 6
2011-11-11protein level
2 5 6
2011-08-23protein level
2 5 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y5V3-1
1 21 3 86107.026
NX_Q9Y5V3-2
3 21 3 91900.8016
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-716006,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
2 EBI-716006,EBI-746056 RBFOX2  
  .neuromuscular process controlling balance
.dendrite morphogenesis
.negative regulation of transcription, DNA-templated
  + 8 more...
.poly(A) RNA binding
.transcription factor binding
.mRNA binding
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-716006,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
4 EBI-716006,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
5 EBI-716006,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
6 EBI-716006,EBI-747185 BAG3  
  .regulation of cellular response to heat
.extrinsic apoptotic signaling pathway in absence of ligand
.cellular response to mechanical stimulus
  + 8 more...
.N/A .neuron projection
.Z disc
.plasma membrane
  + 2 more...
7 EBI-716006,EBI-718700 CA8  
  .phosphatidylinositol-mediated signaling
.one-carbon metabolic process
.zinc ion binding
.carbonate dehydratase activity
.cytoplasm
8 EBI-716006,EBI-1048945 KRTAP19-5  
  .N/A .N/A .intermediate filament
9 EBI-716006,EBI-8636434 TTC32  
  .N/A .N/A .N/A
10 EBI-716006,EBI-6447954 TTC23  
  .N/A .N/A .N/A
11 EBI-716006,EBI-946029 C1orf94  
  .N/A .N/A .N/A
12 EBI-716006,EBI-780319 RBM23  
  .mRNA processing .RNA binding
.nucleotide binding
.membrane
.nucleus
13 EBI-716006,EBI-714606 PJA1  
  .protein catabolic process
.protein ubiquitination
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.cytoplasm
14 EBI-716006,EBI-2822515 SMAP2  
  .N/A .zinc ion binding
.GTPase activator activity
.cytoplasm
.nucleoplasm
15 EBI-716006,EBI-357061 TFG  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.signal transduction
.signal transducer activity .extracellular exosome
.cytoplasm
16 EBI-716006,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
17 EBI-716006,EBI-948288 ZNF488  
  .positive regulation of oligodendrocyte differentiation
.negative regulation of transcription, DNA-templated
.oligodendrocyte development
  + 2 more...
.metal ion binding
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
18 EBI-716006,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
19 EBI-716006,EBI-9641546 AKAP9  
  .positive regulation of potassium ion transmembrane transporter activity
.regulation of heart rate by cardiac conduction
.cellular response to cAMP
  + 11 more...
.ion channel binding
.protein complex scaffold
.potassium channel regulator activity
.receptor binding
.intracellular membrane-bounded organelle
.ciliary basal body
.voltage-gated potassium channel complex
  + 5 more...
20 EBI-716006,EBI-372094 RHOXF2  
  .regulation of transcription, DNA-templated .sequence-specific DNA binding .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland212
ascites125
bladder33
blood163
bone279
bone marrow82
brain185
cervix20
connective tissue114
ear434
embryonic tissue422
eye191
heart245
intestine129
kidney123
larynx85
liver224
lung304
lymph225
lymph node111
mammary gland138
mouth15
muscle169
nerve450
ovary354
pancreas276
parathyroid97
pharynx49
pituitary gland484
placenta296
prostate163
salivary gland542
skin725
spleen56
stomach125
testis137
thyroid193
tonsil58
umbilical cord145
uterus206
vascular19
Health State
TissuesTPM*
normal137
adrenal tumor474
bladder carcinoma113
breast (mammary gland) tumor161
chondrosarcoma531
colorectal tumor168
gastrointestinal tumor177
germ cell tumor273
glioma289
head and neck tumor171
kidney tumor319
leukemia179
liver tumor385
lung tumor379
lymphoma221
non-neoplasia134
ovarian tumor196
pancreatic tumor485
primitive neuroectodermal tumor of the CNS614
prostate cancer260
skin tumor1108
soft tissue/muscle tissue tumor319
uterine tumor332
Developmental Stage
TissuesTPM*
adult160
embryoid body485
blastocyst439
neonate96
fetus163
infant85
juvenile359
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.8
adrenal gland86.7
appendix37.9
bone marrow13.4
cerebral cortex105.1
colon47.3
duodenum31.9
esophagus28.8
gallbladder72.9
heart muscle58.6
kidney42.5
liver43.8
lung41
lymph node33.2
ovary69.5
pancreas37.2
placenta114.6
prostate73.1
salivary gland62.4
skin24.5
small intestine25.5
spleen27.7
stomach57.4
testis63.6
thyroid gland84.7
urinary bladder64.9
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*300224, gene) Melanoma antigen, family d, 1; MAGED1OMIM


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