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> Protein (NX_Q9Y5X1)
Protein (NX_Q9Y5X1)
Protein
Gene SymbolSNX9 to neXtProt (NX_Q9Y5X1)
DescriptionSorting nexin-9
Chromosome6
Location6q25.3 (158244296 ~ 158366109) to Ensembl
Sequene Features : Isoforms 1, Variants 68, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane tubulation
.lipid tube assembly
.positive regulation of membrane protein ectodomain proteolysis
  + 11 more...
.Arp2/3 complex binding
.protein homodimerization activity
.phosphatidylinositol binding
  + 2 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic vesicle membrane
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 68 4
2014-09-19protein level
1 45 4
2014-05-27protein level
1 45 4
2014-02-25protein level
1 45 4
2013-12-09protein level
1 38 4
2013-11-01protein level
1 36 3
2013-09-12protein level
1 36 3
2013-08-17protein level
1 36 3
2013-07-15protein level
1 26 3
2013-06-11protein level
1 26 3
2013-02-12protein level
1 15 3
2012-12-20protein level
1 12 3
2012-10-30protein level
1 16 3
2012-10-07protein level
1 16 3
2012-08-24protein level
1 16 3
2012-07-28protein level
1 16 3
2012-06-08protein level
1 23 3
2012-05-07protein level
1 21 3
2012-04-10protein level
1 21 3
2012-01-13protein level
1 11 3
2011-12-20protein level
1 11 3
2011-11-11protein level
1 11 3
2011-08-23protein level
1 11 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y5X1-1
21 0 0 66549.4297
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-77848,EBI-957615 WASL  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of lymphocyte migration
.positive regulation of clathrin-mediated endocytosis
  + 24 more...
.GTPase regulator activity .extracellular exosome
.endocytic vesicle membrane
.actin cap
  + 6 more...
2 EBI-77848,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
3 EBI-77848,EBI-495538 FASLG  
  .positive regulation of endothelial cell apoptotic process
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 30 more...
.receptor binding .extracellular exosome
.cytoplasmic membrane-bounded vesicle lumen
.perinuclear region of cytoplasm
  + 8 more...
4 EBI-77848,EBI-346547 DNM2  
  .negative regulation of membrane tubulation
.membrane organization
.regulation of nitric-oxide synthase activity
  + 16 more...
.enzyme binding
.SH3 domain binding
.microtubule binding
  + 2 more...
.extracellular exosome
.postsynaptic membrane
.endocytic vesicle membrane
  + 10 more...
5 EBI-77848,EBI-713135 DNM1  
  .clathrin-mediated endocytosis
.ephrin receptor signaling pathway
.receptor internalization
  + 4 more...
.poly(A) RNA binding
.identical protein binding
.protein kinase binding
  + 2 more...
.extracellular exosome
.membrane coat
.plasma membrane
.microtubule
6 EBI-77848,EBI-297487 SOS1  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 16 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.Ras guanyl-nucleotide exchange factor activity
.DNA binding
.neuronal cell body
.postsynaptic density
.plasma membrane
.cytosol
7 EBI-77848,EBI-298181 SOS2  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 4 more...
.Rho guanyl-nucleotide exchange factor activity
.DNA binding
.cytosol
8 EBI-77848,EBI-77818 ADAM15  
  .negative regulation of receptor binding
.protein kinase C signaling
.cardiac epithelial to mesenchymal transition
  + 11 more...
.SH3 domain binding
.zinc ion binding
.metallopeptidase activity
  + 2 more...
.extracellular exosome
.cell projection
.integral component of membrane
  + 4 more...
9 EBI-77848,EBI-723802 ATRAID  
  .negative regulation of cyclin catabolic process
.positive regulation of osteoblast differentiation
.negative regulation of osteoblast proliferation
  + 3 more...
.N/A .perinuclear region of cytoplasm
.integral component of membrane
.plasma membrane
.nuclear envelope
10 EBI-77848,EBI-2481535 SNX33  
  .positive regulation of protein localization to cell surface
.negative regulation of protein localization to cell surface
.membrane tubulation
  + 12 more...
.identical protein binding
.phosphatidylinositol binding
.cytoplasmic vesicle membrane
.extrinsic component of membrane
.cytoplasmic membrane-bounded vesicle
  + 3 more...
11 EBI-77848,EBI-1564678 ITCH  
  .regulation of protein deubiquitination
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
  + 21 more...
.ubiquitin protein ligase activity
.CXCR chemokine receptor binding
.ribonucleoprotein complex binding
  + 2 more...
.extracellular exosome
.cytoplasmic vesicle
.membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
blood65
bone83
bone marrow20
brain30
cervix103
connective tissue134
embryonic tissue37
eye47
heart67
intestine68
kidney123
liver58
lung77
lymph node89
mammary gland132
muscle37
nerve128
ovary19
pancreas65
parathyroid48
pharynx49
placenta109
prostate47
skin123
stomach31
testis48
trachea38
uterus112
vascular154
Health State
TissuesTPM*
normal78
bladder carcinoma56
breast (mammary gland) tumor118
cervical tumor28
chondrosarcoma193
colorectal tumor44
gastrointestinal tumor33
germ cell tumor26
glioma46
kidney tumor72
leukemia42
liver tumor31
lung tumor38
lymphoma27
non-neoplasia51
ovarian tumor26
pancreatic tumor66
prostate cancer28
skin tumor103
soft tissue/muscle tissue tumor31
uterine tumor110
Developmental Stage
TissuesTPM*
adult83
embryoid body57
blastocyst32
neonate128
fetus84
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue36.7
adrenal gland22.3
appendix23.6
bone marrow16.1
cerebral cortex11.8
colon30.3
duodenum26.4
esophagus49.7
gallbladder46
heart muscle21.9
kidney27.4
liver21.1
lung14
lymph node21.3
ovary25.3
pancreas12.8
placenta43.6
prostate26.2
salivary gland20.6
skin15.4
small intestine30.3
spleen15.9
stomach30.1
testis14.6
thyroid gland28.4
urinary bladder40.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605952, gene) Sorting nexin 9; SNX9OMIM


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