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> Protein (NX_Q9Y6A5)
Protein (NX_Q9Y6A5)
Protein
Gene SymbolTACC3 to neXtProt (NX_Q9Y6A5)
DescriptionTransforming acidic coiled-coil-containing protein 3
Chromosome4
Location4p16.3 (1723227 ~ 1746898) to Ensembl
Sequene Features : Isoforms 1, Variants 107, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell cycle
.cytoplasmic sequestering of transcription factor
.regulation of microtubule-based process
  + 8 more...
.N/A .centrosome
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 107 15
2014-09-19protein level
1 98 15
2014-05-27protein level
1 98 15
2014-02-25protein level
1 97 15
2013-12-09protein level
1 65 15
2013-11-01protein level
1 61 13
2013-09-12protein level
1 61 13
2013-08-17protein level
1 61 13
2013-07-15protein level
1 45 12
2013-06-11protein level
1 45 12
2013-02-12protein level
1 31 11
2012-12-20protein level
1 30 11
2012-10-30protein level
1 37 11
2012-10-07protein level
1 37 11
2012-08-24protein level
1 36 11
2012-07-28protein level
1 36 11
2012-06-08protein level
1 40 11
2012-05-07protein level
1 34 11
2012-04-10protein level
1 34 11
2012-01-13protein level
1 20 11
2011-12-20protein level
1 20 11
2011-11-11protein level
1 20 9
2011-08-23protein level
1 20 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y6A5-1
31 0 0 90303.4966
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2554984,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
2 EBI-2554984,EBI-1171169 CLTA  
  .clathrin-mediated endocytosis
.membrane organization
.neurotrophin TRK receptor signaling pathway
  + 6 more...
.peptide binding
.clathrin heavy chain binding
.structural molecule activity
.clathrin complex
.intracellular membrane-bounded organelle
.trans-Golgi network membrane
  + 9 more...
3 EBI-2554984,EBI-310585 CKAP5  
  .cell division
.centrosome organization
.RNA transport
  + 7 more...
.N/A .protein complex
.membrane
.cytosol
  + 2 more...
4 EBI-2554984,EBI-2554344 KIZ  
  .spindle organization .protein kinase binding .cell projection
.centrosome
.cytoplasm
5 EBI-2554984,EBI-744896 SNX20  
  .protein transport .phosphatidylinositol binding .endosome membrane
.plasma membrane
.nucleus
6 EBI-2554984,EBI-10292696 CIB3  
  .N/A .calcium ion binding .N/A
7 EBI-2554984,EBI-1993677 ASPSCR1  
  .membrane organization
.regulation of glucose import
.glucose homeostasis
.intracellular protein transport
.N/A .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.endoplasmic reticulum-Golgi intermediate compartment membrane
  + 7 more...
8 EBI-2554984,EBI-8787464 TBC1D22B  
  .N/A .GTPase activator activity .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
bladder66
blood171
bone69
bone marrow61
brain7
cervix123
embryonic tissue140
eye67
heart22
intestine21
kidney52
liver24
lung62
lymph338
lymph node144
mammary gland85
muscle37
nerve64
ovary9
pancreas65
parathyroid48
pharynx24
placenta14
prostate58
salivary gland49
skin52
spleen37
stomach20
testis50
thymus112
tonsil117
uterus81
vascular19
Health State
TissuesTPM*
normal32
breast (mammary gland) tumor128
cervical tumor144
chondrosarcoma24
colorectal tumor17
gastrointestinal tumor50
germ cell tumor98
glioma27
head and neck tumor7
kidney tumor116
leukemia158
liver tumor31
lung tumor194
lymphoma277
non-neoplasia10
pancreatic tumor104
primitive neuroectodermal tumor of the CNS78
prostate cancer105
retinoblastoma64
skin tumor87
soft tissue/muscle tissue tumor79
uterine tumor110
Developmental Stage
TissuesTPM*
adult43
embryoid body128
blastocyst227
fetus28
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.1
adrenal gland3.7
appendix30.6
bone marrow62.7
cerebral cortex2.4
colon10.1
duodenum12.3
esophagus7
gallbladder7.1
heart muscle3
kidney2.2
liver2.7
lung7.4
lymph node48
ovary1.7
pancreas1.5
placenta11.3
prostate2.5
salivary gland4.5
skin8.2
small intestine11.6
spleen22
stomach8.5
testis51
thyroid gland2.2
urinary bladder10.6
Tissues
TissuesExpression level
appendixMedium
bone marrowHigh
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexLow
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Low
epididymisLow
esophagusMedium
fallopian tubeLow
hippocampusMedium
kidneyLow
lateral ventricleLow
lungLow
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryLow
placentaMedium
prostateLow
rectumMedium
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandLow
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605303, gene) Transforming, acidic, coiled-coil-containing protein 3; TACC3OMIM


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