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> Protein (NX_Q9Y6H1)
Protein (NX_Q9Y6H1)
Protein
Gene SymbolCHCHD2 to neXtProt (NX_Q9Y6H1)
DescriptionCoiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial
Chromosome7
Location7p11.2 (56169262 ~ 56174269) to Ensembl
Sequene Features : Isoforms 1, Variants 20, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cellular response to hypoxia
.positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.transcription factor binding
.mitochondrion
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 20 0
2014-09-19protein level
1 14 0
2014-05-27protein level
1 14 0
2014-02-25protein level
1 14 0
2013-12-09protein level
1 11 0
2013-11-01protein level
1 11 0
2013-09-12protein level
1 11 1
2013-08-17protein level
1 11 1
2013-07-15protein level
1 8 1
2013-06-11protein level
1 8 1
2013-02-12protein level
1 3 1
2012-12-20protein level
1 3 1
2012-10-30protein level
1 4 1
2012-10-07protein level
1 4 1
2012-08-24protein level
1 4 1
2012-07-28protein level
1 4 1
2012-06-08protein level
1 5 1
2012-05-07protein level
1 5 1
2012-04-10protein level
1 5 1
2012-01-13protein level
1 3 1
2011-12-20protein level
1 3 1
2011-11-11protein level
1 3 1
2011-08-23protein level
1 3 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y6H1-1
4 0 0 15502.6575
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2321769,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
2 EBI-2321769,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
3 EBI-2321769,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
4 EBI-2321769,EBI-6509505 INCA1  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of cell proliferation
.cyclin binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleus
5 EBI-2321769,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
6 EBI-2321769,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
7 EBI-2321769,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
8 EBI-2321769,EBI-2865388 LHX4  
  .negative regulation of apoptotic process
.medial motor column neuron differentiation
.organ morphogenesis
  + 4 more...
.sequence-specific DNA binding
.zinc ion binding
.nucleus
9 EBI-2321769,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
10 EBI-2321769,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites251
bladder33
blood98
bone125
bone marrow123
brain121
cervix268
connective tissue73
ear124
embryonic tissue79
eye186
heart268
intestine232
kidney113
larynx42
liver92
lung158
lymph180
lymph node44
mammary gland185
mouth60
muscle206
nerve64
ovary167
pancreas299
parathyroid1068
pharynx122
pituitary gland968
placenta130
prostate284
salivary gland246
skin393
spleen74
stomach365
testis117
thymus37
thyroid85
tonsil293
umbilical cord508
uterus275
vascular154
Health State
TissuesTPM*
normal133
adrenal tumor79
breast (mammary gland) tumor161
cervical tumor376
chondrosarcoma132
colorectal tumor319
gastrointestinal tumor295
germ cell tumor94
glioma158
head and neck tumor119
kidney tumor203
leukemia158
liver tumor145
lung tumor214
lymphoma180
non-neoplasia41
ovarian tumor105
pancreatic tumor209
primitive neuroectodermal tumor of the CNS125
prostate cancer423
retinoblastoma215
skin tumor446
soft tissue/muscle tissue tumor239
uterine tumor443
Developmental Stage
TissuesTPM*
adult202
embryoid body85
blastocyst16
neonate225
fetus26
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue63.5
adrenal gland189.3
appendix65.2
bone marrow94
cerebral cortex65.3
colon86.4
duodenum85
esophagus61.7
gallbladder56
heart muscle98.8
kidney88.5
liver52.2
lung55
lymph node72.4
ovary67.6
pancreas39
placenta60.8
prostate83.3
salivary gland80.5
skin40.2
small intestine83
spleen64
stomach78.9
testis45
thyroid gland62.2
urinary bladder62.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineHigh
soft tissue 1Low
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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