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> Protein (NX_Q9Y6K9)
Protein (NX_Q9Y6K9)
Protein
Gene SymbolIKBKG to neXtProt (NX_Q9Y6K9)
DescriptionNF-kappa-B essential modulator
ChromosomeX
LocationXq28 (153769414 ~ 153796782) to Ensembl
Sequene Features : Isoforms 3, Variants 24, PTMs 28 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 24 28
2014-09-19protein level
3 24 28
2014-05-27protein level
3 24 28
2014-02-25protein level
3 24 28
2013-12-09protein level
3 22 28
2013-11-01protein level
3 22 28
2013-09-12protein level
3 22 28
2013-08-17protein level
3 22 28
2013-07-15protein level
3 20 28
2013-06-11protein level
3 20 28
2013-02-12protein level
3 19 80
2012-12-20protein level
3 18 80
2012-10-30protein level
3 21 80
2012-10-07protein level
3 21 29
2012-08-24protein level
3 21 29
2012-07-28protein level
3 21 29
2012-06-08protein level
3 32 29
2012-05-07protein level
3 32 29
2012-04-10protein level
3 32 29
2012-01-13protein level
3 33 29
2011-12-20protein level
3 33 29
2011-11-11protein level
3 33 28
2011-08-23protein level
3 32 28
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y6K9-1
0 18 0 48167.222
NX_Q9Y6K9-2
4 18 0 55751.3287
NX_Q9Y6K9-3
0 13 0 36929.5079
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-81279,EBI-81266 IKBKB  
  .positive regulation of cation channel activity
.cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
  + 32 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
2 EBI-81279,EBI-81249 CHUK  
  .cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
.mammary gland alveolus development
  + 45 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.intracellular membrane-bounded organelle
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
3 EBI-81279,EBI-447544 MYC  
  .positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
4 EBI-81279,EBI-359977 TNF  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of chemokine (C-X-C motif) ligand 2 production
.positive regulation of protein localization to cell surface
  + 113 more...
.transcription regulatory region DNA binding
.identical protein binding
.tumor necrosis factor receptor binding
  + 2 more...
.recycling endosome
.membrane raft
.cell surface
  + 6 more...
5 EBI-81279,EBI-354007 ANXA1  
  .negative regulation of interleukin-8 secretion
.negative regulation of phospholipase A2 activity
.positive regulation of G1/S transition of mitotic cell cycle
  + 30 more...
.calcium-dependent protein binding
.annealing helicase activity
.double-stranded DNA-dependent ATPase activity
  + 10 more...
.extracellular exosome
.protein complex
.mast cell granule
  + 14 more...
6 EBI-81279,EBI-297888 KRT18  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.intermediate filament cytoskeleton organization
  + 6 more...
.scaffold protein binding
.poly(A) RNA binding
.structural molecule activity
.cell periphery
.extracellular exosome
.perinuclear region of cytoplasm
  + 6 more...
7 EBI-81279,EBI-297852 KRT8  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.cell differentiation involved in embryonic placenta development
  + 5 more...
.scaffold protein binding
.structural molecule activity
.extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 10 more...
8 EBI-81279,EBI-4286943 CALB1  
  .metanephric connecting tubule development
.metanephric distal convoluted tubule development
.metanephric collecting duct development
  + 8 more...
.zinc ion binding
.calcium ion binding
.vitamin D binding
.extracellular exosome
.synapse
.neuronal cell body
  + 4 more...
9 EBI-81279,EBI-296047 HSP90AA1  
  .regulation of cellular response to heat
.positive regulation of cardiac muscle contraction
.chaperone-mediated protein complex assembly
  + 26 more...
.GTPase binding
.poly(A) RNA binding
.protein homodimerization activity
  + 12 more...
.endocytic vesicle lumen
.extracellular exosome
.perinuclear region of cytoplasm
  + 17 more...
10 EBI-81279,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
11 EBI-81279,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
12 EBI-81279,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
13 EBI-81279,EBI-524909 SYT1  
  .positive regulation of dendrite extension
.regulation of regulated secretory pathway
.fast, calcium ion-dependent exocytosis of neurotransmitter
  + 16 more...
.low-density lipoprotein particle receptor binding
.clathrin binding
.syntaxin-1 binding
  + 6 more...
.clathrin-sculpted monoamine transport vesicle membrane
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
.clathrin-sculpted glutamate transport vesicle membrane
  + 12 more...
14 EBI-81279,EBI-527670 TNFAIP3  
  .negative regulation of endothelial cell apoptotic process
.negative regulation of CD40 signaling pathway
.positive regulation of hepatocyte proliferation
  + 46 more...
.protein self-association
.ubiquitin binding
.ligase activity
  + 5 more...
.extracellular exosome
.cytosol
.centrosome
  + 3 more...
15 EBI-81279,EBI-375096 CDK2  
  .cellular response to nitric oxide
.regulation of gene silencing
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 20 more...
.metal ion binding
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.Cajal body
.cytosol
.centrosome
  + 10 more...
16 EBI-81279,EBI-307386 NFKBIA  
  .nucleotide-binding oligomerization domain containing 2 signaling pathway
.nucleotide-binding oligomerization domain containing 1 signaling pathway
.cellular response to cold
  + 39 more...
.NF-kappaB binding
.identical protein binding
.ubiquitin protein ligase binding
  + 3 more...
.I-kappaB/NF-kappaB complex
.plasma membrane
.cytosol
  + 2 more...
17 EBI-81279,EBI-3946257 FLT3  
  .dendritic cell differentiation
.cellular response to glucocorticoid stimulus
.cellular response to cytokine stimulus
  + 24 more...
.protein homodimerization activity
.ATP binding
.vascular endothelial growth factor-activated receptor activity
  + 2 more...
.protein complex
.external side of plasma membrane
.integral component of plasma membrane
  + 3 more...
18 EBI-81279,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
19 EBI-81279,EBI-712311 PPP2CA  
  .positive regulation of protein serine/threonine kinase activity
.protein heterotrimerization
.meiotic cell cycle
  + 25 more...
.metal ion binding
.protein serine/threonine phosphatase activity
.extracellular exosome
.membrane
.microtubule cytoskeleton
  + 7 more...
20 EBI-81279,EBI-495465 ATM  
  .regulation of cellular response to heat
.replicative senescence
.signal transduction involved in mitotic G2 DNA damage checkpoint
  + 33 more...
.protein N-terminus binding
.protein dimerization activity
.histone serine kinase activity
  + 6 more...
.cytoplasmic membrane-bounded vesicle
.spindle
.nucleoplasm
21 EBI-81279,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
22 EBI-81279,EBI-968983 ATR  
  .regulation of cellular response to heat
.replicative senescence
.cellular response to gamma radiation
  + 15 more...
.protein dimerization activity
.MutSalpha complex binding
.MutLalpha complex binding
  + 4 more...
.PML body
.Golgi apparatus
.chromosome
  + 2 more...
23 EBI-81279,EBI-358507 RIPK1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 48 more...
.death domain binding
.identical protein binding
.protein complex binding
  + 5 more...
.ripoptosome
.membrane raft
.receptor complex
  + 4 more...
24 EBI-81279,EBI-1046878 GIT2  
  .behavioral response to pain
.regulation of G-protein coupled receptor protein signaling pathway
.zinc ion binding
.GTPase activator activity
.focal adhesion
.nucleoplasm
25 EBI-81279,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
26 EBI-81279,EBI-295634 CDC37  
  .regulation of type I interferon-mediated signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 3 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.kinase binding
.extracellular exosome
.protein complex
.ruffle membrane
  + 2 more...
27 EBI-81279,EBI-747793 ZC3H12A  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to lipopolysaccharide
.positive regulation of fat cell differentiation
  + 12 more...
.metal ion binding
.endonuclease activity
.plasma membrane
.cytoplasm
.nucleoplasm
28 EBI-81279,EBI-2683099 ARL6IP4  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding .nuclear speck
.nucleolus
.nucleus
29 EBI-81279,EBI-359372 TNIP2  
  .negative regulation of endothelial cell apoptotic process
.cellular response to lipopolysaccharide
.interleukin-1-mediated signaling pathway
  + 13 more...
.polyubiquitin binding
.protein kinase binding
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
30 EBI-81279,EBI-6257338 RUSC1  
  .positive regulation of signal transduction
.protein polyubiquitination
.SH3/SH2 adaptor activity
.actin binding
.postsynaptic membrane
.cytoplasmic vesicle
.cell junction
  + 8 more...
31 EBI-81279,EBI-2340624 RBCK1  
  .positive regulation of extrinsic apoptotic signaling pathway
.protein linear polyubiquitination
.negative regulation of necroptotic process
  + 8 more...
.ubiquitin binding
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.LUBAC complex
32 EBI-81279,EBI-3942966 SHARPIN  
  .regulation of CD40 signaling pathway
.protein linear polyubiquitination
.protein homooligomerization
  + 7 more...
.polyubiquitin binding
.zinc ion binding
.LUBAC complex
.dendrite
.cell junction
  + 5 more...
33 EBI-81279,EBI-714881 SENP2  
  .regulation of G1/S transition of mitotic cell cycle
.spongiotrophoblast layer development
.labyrinthine layer development
  + 21 more...
.SUMO-specific protease activity .nuclear membrane
.cytoplasmic vesicle
.PML body
  + 2 more...
34 EBI-81279,EBI-718895 ADAP2  
  .heart development .inositol 1,3,4,5 tetrakisphosphate binding
.phosphatidylinositol-3,4-bisphosphate binding
.protein binding, bridging
  + 4 more...
.plasma membrane
.mitochondrial envelope
.cytoplasm
35 EBI-81279,EBI-398632 RNF7  
  .response to redox state
.protein neddylation
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
.cullin family protein binding
.ubiquitin protein ligase activity
.NEDD8 transferase activity
  + 2 more...
.Cul4-RING E3 ubiquitin ligase complex
.nuclear SCF ubiquitin ligase complex
.Cul7-RING ubiquitin ligase complex
  + 6 more...
36 EBI-81279,EBI-1047372 MALT1  
  .protein oligomerization
.nuclear export
.positive regulation of NF-kappaB transcription factor activity
  + 20 more...
.protein self-association
.peptidase activity
.signal transducer activity
  + 2 more...
.perinuclear region of cytoplasm
.protein complex
.CBM complex
  + 5 more...
37 EBI-81279,EBI-356402 TBK1  
  .defense response to virus
.defense response to Gram-positive bacterium
.positive regulation of transcription from RNA polymerase II promoter
  + 20 more...
.phosphoprotein binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.endosome membrane
.cytosol
.cytoplasm
38 EBI-81279,EBI-350590 COPS3  
  .cullin deneddylation
.response to light stimulus
.signal transduction
  + 2 more...
.N/A .COP9 signalosome
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites376
blood114
bone83
brain29
cervix20
connective tissue33
embryonic tissue18
esophagus49
eye47
intestine51
kidney9
larynx42
liver19
lung53
lymph67
lymph node44
mammary gland13
mouth15
muscle18
ovary49
pancreas65
placenta45
prostate52
salivary gland148
skin109
spleen74
stomach31
testis2
thymus12
uterus30
Health State
TissuesTPM*
normal29
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma48
colorectal tumor62
esophageal tumor57
gastrointestinal tumor135
germ cell tumor26
glioma46
head and neck tumor37
kidney tumor29
leukemia105
liver tumor20
lung tumor126
lymphoma152
non-neoplasia20
ovarian tumor26
pancreatic tumor85
primitive neuroectodermal tumor of the CNS70
prostate cancer67
retinoblastoma43
skin tumor119
soft tissue/muscle tissue tumor39
uterine tumor66
Developmental Stage
TissuesTPM*
adult54
blastocyst32
fetus25
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.1
adrenal gland13.5
appendix19.5
bone marrow19.3
cerebral cortex11
colon9.9
duodenum14.4
esophagus15
gallbladder14.3
heart muscle9.7
kidney8.7
liver11.4
lung20.2
lymph node22.6
ovary11.1
pancreas5.3
placenta9.6
prostate11.1
salivary gland8.6
skin20.3
small intestine13
spleen25.8
stomach13.6
testis14.1
thyroid gland10.7
urinary bladder13.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusMedium
fallopian tubeHigh
gallbladderMedium
kidneyMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasLow
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300248, gene) Inhibitor of kappa light polypeptide gene enhancer in b cells, kinaseOMIM
2(#300291, phenotype) Ectodermal dysplasia, hypohidrotic, with immune deficiencyOMIM
3(#300301, phenotype) Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis,OMIM
4(#300584, phenotype) Immunodeficiency without anhidrotic ectodermal dysplasiaOMIM
5(#300636, phenotype) Atypical mycobacteriosis, familial, x-linked 1; AMCBX1OMIM
6(#300640, phenotype) Invasive pneumococcal disease, recurrent isolated, 2; IPD2OMIM
7(#308300, phenotype) Incontinentia pigmenti; IPOMIM


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