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> Protein (NX_Q9Y6Q6)
Protein (NX_Q9Y6Q6)
Protein
Gene SymbolTNFRSF11A to neXtProt (NX_Q9Y6Q6)
DescriptionTumor necrosis factor receptor superfamily member 11A
Chromosome18
Location18q21.33 (59992520 ~ 60058516) to Ensembl
Sequene Features : Isoforms 6, Variants 83, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
.TNFSF11-mediated signaling pathway
.positive regulation of fever generation by positive regulation of prostaglandin secretion
  + 19 more...
.metal ion binding
.cytokine binding
.tumor necrosis factor-activated receptor activity
  + 2 more...
.integral component of membrane
.external side of plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 83 13
2014-09-19protein level
6 69 13
2014-05-27protein level
6 69 13
2014-02-25protein level
2 69 13
2013-12-09protein level
2 57 13
2013-11-01protein level
2 55 13
2013-09-12protein level
2 55 13
2013-08-17protein level
2 55 13
2013-07-15protein level
1 47 13
2013-06-11protein level
1 47 13
2013-02-12protein level
1 30 13
2012-12-20protein level
1 29 13
2012-10-30protein level
1 29 13
2012-10-07protein level
1 29 13
2012-08-24protein level
1 28 13
2012-07-28protein level
1 28 13
2012-06-08protein level
1 28 13
2012-05-07protein level
1 19 13
2012-04-10protein level
1 19 13
2012-01-13protein level
1 20 13
2011-12-20protein level
1 20 13
2011-11-11protein level
1 20 13
2011-08-23protein level
1 20 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y6Q6-1
0 27 0 65990.9231
NX_Q9Y6Q6-2
1 14 0 32296.4062
NX_Q9Y6Q6-3
1 15 0 36374.7879
NX_Q9Y6Q6-4
0 12 0 28945.1471
NX_Q9Y6Q6-5
1 22 0 56365.2527
NX_Q9Y6Q6-6
1 25 0 64510.1203
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain2
cervix20
embryonic tissue4
heart22
intestine21
kidney14
liver4
lung2
pancreas18
skin4
stomach10
thyroid21
trachea19
vascular19
Health State
TissuesTPM*
normal3
cervical tumor28
chondrosarcoma12
colorectal tumor35
gastrointestinal tumor8
glioma9
head and neck tumor7
liver tumor10
lung tumor9
skin tumor7
Developmental Stage
TissuesTPM*
adult6
blastocyst16
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.7
adrenal gland1.2
appendix6.2
cerebral cortex1.2
colon19.1
duodenum27.6
esophagus2.7
gallbladder9
lung1.1
lymph node1.2
placenta3.3
prostate1.4
salivary gland19.1
skin2.5
small intestine18.9
stomach7
thyroid gland1.1
urinary bladder1.6
Tissues
TissuesExpression level
adrenal glandMedium
bone marrowLow
breastLow
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineLow
colonLow
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusHigh
kidneyLow
lateral ventricleHigh
liverLow
lymph nodeLow
nasopharynxMedium
pancreasLow
parathyroid glandLow
placentaLow
rectumLow
skeletal muscleMedium
skin 1Low
skin 2Low
small intestineMedium
smooth muscleLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#174810, phenotype) Familial expansile osteolysis; FEOOMIM
2(#602080, phenotype) Paget disease of bone; PDBOMIM
3(*603499, gene) Tumor necrosis factor receptor superfamily, member 11a; TNFRSF11AOMIM
4(#612301, phenotype) Osteopetrosis, autosomal recessive 7; OPTB7OMIM


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