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> Protein (NX_Q9Y6Q9)
Protein (NX_Q9Y6Q9)
Protein
Gene SymbolNCOA3 to neXtProt (NX_Q9Y6Q9)
DescriptionNuclear receptor coactivator 3
Chromosome20
Location20q13.12 (46130601 ~ 46285621) to Ensembl
Sequene Features : Isoforms 5, Variants 180, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of RNA biosynthetic process
.mammary gland branching involved in thelarche
.labyrinthine layer morphogenesis
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.thyroid hormone receptor binding
  + 7 more...
.extracellular exosome
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 180 20
2014-09-19protein level
5 138 20
2014-05-27protein level
5 138 20
2014-02-25protein level
5 138 16
2013-12-09protein level
5 109 16
2013-11-01protein level
5 103 16
2013-09-12protein level
5 103 16
2013-08-17protein level
5 103 16
2013-07-15protein level
5 72 15
2013-06-11protein level
5 72 15
2013-02-12protein level
5 44 66
2012-12-20protein level
5 45 66
2012-10-30protein level
5 50 66
2012-10-07protein level
5 50 14
2012-08-24protein level
5 48 14
2012-07-28protein level
5 48 14
2012-06-08protein level
5 43 14
2012-05-07protein level
5 43 14
2012-04-10protein level
5 43 14
2012-01-13protein level
5 39 14
2011-12-20protein level
5 39 14
2011-11-11protein level
5 39 10
2011-08-23protein level
5 39 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y6Q9-1
0 58 0 155194.4273
NX_Q9Y6Q9-2
0 57 0 153698.6938
NX_Q9Y6Q9-3
0 57 0 154301.9827
NX_Q9Y6Q9-4
1 51 0 147405.5513
NX_Q9Y6Q9-5
0 58 0 154793.2374
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-81196,EBI-81266 IKBKB  
  .positive regulation of cation channel activity
.cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
  + 32 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
2 EBI-81196,EBI-743549 SPOP  
  .positive regulation of type B pancreatic cell apoptotic process
.positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin protein ligase binding .Cul3-RING ubiquitin ligase complex
.nuclear speck
.nucleoplasm
.nucleus
3 EBI-81196,EBI-78473 ESR1  
  .cellular response to estradiol stimulus
.epithelial cell proliferation involved in mammary gland duct elongation
.mammary gland alveolus development
  + 33 more...
.ATPase binding
.identical protein binding
.estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 14 more...
.transcriptionally active chromatin
.integral component of membrane
.membrane
  + 5 more...
4 EBI-81196,EBI-413374 RARA  
  .cellular response to estrogen stimulus
.cellular response to retinoic acid
.cellular response to lipopolysaccharide
  + 54 more...
.alpha-actinin binding
.protein kinase A binding
.mRNA 5'-UTR binding
  + 19 more...
.perinuclear region of cytoplasm
.neuronal cell body
.dendrite
  + 6 more...
5 EBI-81196,EBI-603300 PSMB9  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.spermatoproteasome complex
.extracellular exosome
.proteasome core complex
  + 5 more...
6 EBI-81196,EBI-696162 PTEN  
  .positive regulation of apoptotic signaling pathway
.negative regulation of synaptic vesicle clustering
.positive regulation of excitatory postsynaptic membrane potential
  + 91 more...
.phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
.inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
.PDZ domain binding
  + 10 more...
.postsynaptic membrane
.Schmidt-Lanterman incisure
.dendritic spine
  + 12 more...
7 EBI-81196,EBI-355546 PSME3  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.MDM2/MDM4 family protein binding
.endopeptidase activator activity
.identical protein binding
.p53 binding
.membrane
.proteasome activator complex
.cytosol
  + 4 more...
8 EBI-81196,EBI-447295 EP300  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.regulation of tubulin deacetylation
  + 40 more...
.pre-mRNA intronic binding
.androgen receptor binding
.nuclear hormone receptor binding
  + 17 more...
.cytoplasm
.transcription factor complex
.nucleoplasm
  + 2 more...
9 EBI-81196,EBI-746012 DDX17  
  .regulation of skeletal muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of intracellular estrogen receptor signaling pathway
  + 4 more...
.poly(A) RNA binding
.estrogen receptor binding
.RNA-dependent ATPase activity
  + 5 more...
.membrane
.cytoplasm
.nucleolus
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites150
blood73
bone13
bone marrow61
brain22
cervix82
connective tissue93
embryonic tissue23
esophagus347
eye38
heart55
intestine43
kidney56
larynx85
liver43
lung47
lymph67
lymph node334
mammary gland171
mouth90
muscle75
ovary39
pancreas23
pharynx24
placenta141
prostate26
skin28
spleen18
stomach73
testis45
thymus37
thyroid64
tonsil117
uterus68
vascular58
Health State
TissuesTPM*
normal52
breast (mammary gland) tumor225
cervical tumor115
chondrosarcoma48
colorectal tumor53
esophageal tumor405
gastrointestinal tumor109
germ cell tumor34
glioma27
head and neck tumor74
kidney tumor29
leukemia137
liver tumor83
lung tumor48
lymphoma69
non-neoplasia51
ovarian tumor52
pancreatic tumor19
prostate cancer28
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor143
uterine tumor11
Developmental Stage
TissuesTPM*
adult87
embryoid body42
blastocyst32
neonate32
fetus44
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.2
adrenal gland9
appendix24.5
bone marrow9.7
cerebral cortex5.7
colon10.5
duodenum8.9
esophagus23
gallbladder14.1
heart muscle9.2
kidney9
liver6
lung15.2
lymph node42.8
ovary14.6
pancreas5.6
placenta34.2
prostate9.4
salivary gland8.6
skin12.2
small intestine8.8
spleen27.8
stomach15.2
testis10.1
thyroid gland15.6
urinary bladder30.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryHigh
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1High
soft tissue 2Medium
spleenHigh
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601937, gene) Nuclear receptor coactivator 3; NCOA3OMIM


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