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> Protein (NX_Q9Y6R4)
Protein (NX_Q9Y6R4)
Protein
Gene SymbolMAP3K4 to neXtProt (NX_Q9Y6R4)
DescriptionMitogen-activated protein kinase kinase kinase 4
Chromosome6
Location6q26 (161412759 ~ 161538417) to Ensembl
Sequene Features : Isoforms 2, Variants 201, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of p38MAPK cascade
.chorionic trophoblast cell differentiation
.positive regulation of JUN kinase activity
  + 8 more...
.metal ion binding
.ATP binding
.MAP kinase kinase kinase activity
.MAP kinase kinase activity
.perinuclear region of cytoplasm
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 201 7
2014-09-19protein level
2 158 7
2014-05-27protein level
2 158 8
2014-02-25protein level
2 157 8
2013-12-09protein level
2 133 8
2013-11-01protein level
2 129 8
2013-09-12protein level
2 129 8
2013-08-17protein level
2 129 8
2013-07-15protein level
2 92 8
2013-06-11protein level
2 92 8
2013-02-12protein level
2 39 16
2012-12-20protein level
2 39 16
2012-10-30protein level
2 42 16
2012-10-07protein level
2 42 8
2012-08-24protein level
2 42 8
2012-07-28protein level
2 41 8
2012-06-08protein level
2 48 8
2012-05-07protein level
2 31 8
2012-04-10protein level
2 31 8
2012-01-13protein level
2 19 8
2011-12-20protein level
2 19 8
2011-11-11protein level
2 19 8
2011-08-23protein level
2 19 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y6R4-1
3 73 0 181569.077
NX_Q9Y6R4-2
1 73 0 176900.8207
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-448104,EBI-448187 GADD45B  
  .positive regulation of p38MAPK cascade
.regulation of cell cycle
.positive regulation of JNK cascade
  + 8 more...
.N/A .cytoplasm
.nucleus
2 EBI-448104,EBI-352089 FLNB  
  .cell differentiation
.actin cytoskeleton organization
.cytokine-mediated signaling pathway
  + 3 more...
.poly(A) RNA binding
.identical protein binding
.actin binding
.extracellular exosome
.Z disc
.integral component of membrane
  + 7 more...
3 EBI-448104,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
4 EBI-448104,EBI-448135 MAP2K6  
  .cellular response to sorbitol
.nucleotide-binding oligomerization domain containing signaling pathway
.cardiac muscle contraction
  + 33 more...
.protein kinase binding
.ATP binding
.protein tyrosine kinase activity
  + 2 more...
.cytoskeleton
.cytosol
.cytoplasm
.nucleoplasm
5 EBI-448104,EBI-346595 SH3KBP1  
  .negative regulation of epidermal growth factor receptor signaling pathway
.cell migration
.regulation of cell shape
  + 5 more...
.N/A .synapse
.neuron projection
.cytoplasmic vesicle membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bladder100
blood16
bone69
brain40
cervix20
connective tissue46
embryonic tissue23
eye33
heart22
intestine34
kidney37
larynx85
liver14
lung17
lymph45
lymph node22
mammary gland39
mouth30
muscle9
ovary9
pancreas14
parathyroid97
pharynx122
placenta28
prostate42
salivary gland49
skin9
spleen18
stomach31
testis27
thymus12
trachea38
uterus38
vascular19
Health State
TissuesTPM*
normal33
adrenal tumor79
bladder carcinoma56
cervical tumor28
chondrosarcoma96
colorectal tumor26
gastrointestinal tumor16
germ cell tumor26
glioma27
head and neck tumor59
kidney tumor29
leukemia21
liver tumor10
lymphoma27
pancreatic tumor19
primitive neuroectodermal tumor of the CNS7
prostate cancer48
skin tumor15
soft tissue/muscle tissue tumor63
uterine tumor22
Developmental Stage
TissuesTPM*
adult43
blastocyst48
fetus35
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.2
adrenal gland8.2
appendix12.7
bone marrow8.7
cerebral cortex9.6
colon8.5
duodenum11.1
esophagus13.3
gallbladder9.7
heart muscle7.4
kidney8.3
liver5.3
lung12.4
lymph node12.4
ovary15.3
pancreas4.5
placenta9.2
prostate12.8
salivary gland10
skin15.7
small intestine8.5
spleen10.5
stomach8.1
testis18.6
thyroid gland11.9
urinary bladder14.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602425, gene) Mitogen-activated protein kinase kinase kinase 4; MAP3K4OMIM


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