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> Protein (NX_Q9Y6X0)
Protein (NX_Q9Y6X0)
Protein
Gene SymbolSETBP1 to neXtProt (NX_Q9Y6X0)
DescriptionSET-binding protein
Chromosome18
Location18q12.3 (42260138 ~ 42648475) to Ensembl
Sequene Features : Isoforms 2, Variants 300, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .DNA binding .nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 300 3
2014-09-19protein level
2 228 3
2014-05-27protein level
2 228 3
2014-02-25protein level
2 221 2
2013-12-09protein level
2 196 2
2013-11-01protein level
2 188 2
2013-09-12protein level
2 173 2
2013-08-17protein level
2 173 2
2013-07-15protein level
2 126 2
2013-06-11protein level
2 126 2
2013-02-12protein level
2 41 1
2012-12-20protein level
2 41 1
2012-10-30protein level
2 47 1
2012-10-07protein level
2 47 1
2012-08-24protein level
2 45 1
2012-07-28protein level
2 45 1
2012-06-08protein level
2 45 1
2012-05-07protein level
2 32 1
2012-04-10protein level
2 32 1
2012-01-13protein level
2 22 1
2011-12-20protein level
2 22 1
2011-11-11protein level
2 22 1
2011-08-23protein level
2 22 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9Y6X0-1
60 8 0 174898.5647
NX_Q9Y6X0-2
3 8 0 26380.2645
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2548259,EBI-2842031 YAF2  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding
.transcription corepressor activity
.transcription coactivator activity
.cytoplasm
.nucleoplasm
.nucleus
2 EBI-2548259,EBI-10301202 SPANXD  
  .N/A .N/A .cytoplasm
.nucleus
3 EBI-2548259,EBI-742388 PLEKHF2  
  .protein transport .metal ion binding .early endosome membrane
.transport vesicle
.endoplasmic reticulum
4 EBI-2548259,EBI-2340004 XAGE1A  
  .N/A .N/A .N/A
5 EBI-2548259,EBI-10313181 SPANXA1  
  .spermatogenesis .N/A .cytoplasm
.nucleus
6 EBI-2548259,EBI-10316585 SPANXC  
  .N/A .N/A .cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain22
connective tissue13
ear124
embryonic tissue32
eye23
heart11
intestine4
kidney61
larynx42
lung17
lymph node77
mammary gland19
mouth75
muscle9
ovary9
pancreas23
placenta17
prostate47
spleen18
stomach31
testis13
thyroid21
trachea57
uterus17
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor21
gastrointestinal tumor25
germ cell tumor7
glioma9
head and neck tumor14
kidney tumor29
leukemia21
lung tumor19
lymphoma13
non-neoplasia10
ovarian tumor13
pancreatic tumor38
primitive neuroectodermal tumor of the CNS15
prostate cancer28
Developmental Stage
TissuesTPM*
adult19
embryoid body28
blastocyst16
fetus44
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.4
adrenal gland2.1
appendix3.7
cerebral cortex5.1
colon3.7
duodenum1.6
esophagus4.8
gallbladder5.8
heart muscle2.6
kidney7.4
liver2.3
lung4
lymph node5.3
ovary8.1
pancreas2.7
placenta5.6
prostate7.1
salivary gland3.4
skin2.7
small intestine1.8
spleen4
stomach3.2
testis2.4
thyroid gland4.3
urinary bladder6.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#269150, phenotype) Schinzel-giedion midface retraction syndromeOMIM
2(#601626, phenotype) Leukemia, acute myeloid; AMLOMIM
3(#607785, phenotype) Juvenile myelomonocytic leukemia; JMMLOMIM
4(#608232, phenotype) Leukemia, chronic myeloid; CMLOMIM
5(*611060, gene) Set-binding protein 1; SETBP1OMIM
6(#614286, phenotype) Myelodysplastic syndrome; MDSOMIM


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