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> Protein (NX_O60674)
Protein (NX_O60674)
Protein
Gene SymbolJAK2 to neXtProt (NX_O60674)
DescriptionTyrosine-protein kinase JAK2
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
.response to interleukin-12
.mammary gland epithelium development
.positive regulation of growth hormone receptor signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
.growth hormone receptor signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
.positive regulation of nitric-oxide synthase biosynthetic process
.positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of cell activation
.positive regulation of peptidyl-tyrosine phosphorylation
.positive regulation of inflammatory response
.regulation of inflammatory response
.platelet-derived growth factor receptor signaling pathway
.protein autophosphorylation
.response to antibiotic
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of heart contraction
.positive regulation of cell differentiation
.positive regulation of nitric oxide biosynthetic process
.innate immune response
.negative regulation of neuron apoptotic process
.negative regulation of DNA binding
.positive regulation of DNA binding
.regulation of apoptotic process
.activation of JAK2 kinase activity
.positive regulation of tyrosine phosphorylation of Stat5 protein
.positive regulation of tyrosine phosphorylation of Stat3 protein
.tyrosine phosphorylation of Stat1 protein
.tyrosine phosphorylation of Stat5 protein
.tyrosine phosphorylation of Stat3 protein
.regulation of cell proliferation
.peptidyl-tyrosine autophosphorylation
.interleukin-12-mediated signaling pathway
.intracellular signal transduction
.histone H3-Y41 phosphorylation
.response to tumor necrosis factor
.host programmed cell death induced by symbiont
.tumor necrosis factor-mediated signaling pathway
.response to hydroperoxide
.positive regulation of protein import into nucleus, translocation
.positive regulation of tumor necrosis factor production
.positive regulation of interleukin-1 beta production
.positive regulation of phosphoprotein phosphatase activity
.response to lipopolysaccharide
.positive regulation of insulin secretion
.mineralocorticoid receptor signaling pathway
.axon regeneration
.positive regulation of cell migration
.erythrocyte differentiation
.cell differentiation
.actin filament polymerization
.negative regulation of cell-cell adhesion
.cytokine-mediated signaling pathway
.peptidyl-tyrosine phosphorylation
.cell migration
.positive regulation of phosphatidylinositol 3-kinase signaling
.positive regulation of cell-substrate adhesion
.hormone-mediated signaling pathway
.intrinsic apoptotic signaling pathway in response to oxidative stress
.negative regulation of cell proliferation
.positive regulation of cell proliferation
.blood coagulation
.mesoderm development
.STAT protein import into nucleus
.tyrosine phosphorylation of STAT protein
.JAK-STAT cascade
.positive regulation of cytosolic calcium ion concentration
.G-protein coupled receptor signaling pathway
.enzyme linked receptor protein signaling pathway
.signal transduction
.movement of cell or subcellular component
.activation of cysteine-type endopeptidase activity involved in apoptotic process
.apoptotic process
.protein phosphorylation
.chromatin organization
.activation of MAPKK activity
.histone binding
.SH2 domain binding
.histone kinase activity (H3-Y41 specific)
.heme binding
.protein kinase binding
.ATP binding
.interleukin-12 receptor binding
.growth hormone receptor binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.protein kinase activity
.membrane raft
.endosome lumen
.extrinsic component of cytoplasmic side of plasma membrane
.nuclear matrix
.caveola
.cytoskeleton
.cytosol
.cytoplasm
.nucleoplasm
.nucleus


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